Thrombin Primes Responsiveness of Selective Chemoattractant Receptors at a Site Distal to G Protein Activation (∗)

To define the molecular basis of human chemoattractant receptor regulation, rat basophilic leukemia RBL-2H3 cells, which are thrombin-responsive, were transfected to stably express epitope-tagged receptors for C5a, interleukin-8 (IL-8), formylpeptides (e.g. N-formyl-methionyl-leucyl-phenylalanine (f...

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Veröffentlicht in:	The Journal of biological chemistry 1996-02, Vol.271 (6), p.3200-3206
Hauptverfasser:	Ali, Hydar, Tomhave, Eric D., Richardson, Ricardo M., Haribabu, Bodduluri, Snyderman, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, CD - biosynthesis Antigens, CD - isolation & purification Antigens, CD - physiology beta-N-Acetylhexosaminidases - metabolism Binding Sites Calcium - metabolism Cell Line Complement C5a - pharmacology Endopeptidases - pharmacology GTP-Binding Proteins - metabolism Humans Inositol - metabolism Inositol Phosphates - metabolism Interleukin-8 - pharmacology Kinetics Leukemia, Basophilic, Acute Molecular Sequence Data N-Formylmethionine Leucyl-Phenylalanine - pharmacology Peptide Fragments - pharmacology Phosphorylation Platelet Membrane Glycoproteins - biosynthesis Platelet Membrane Glycoproteins - isolation & purification Platelet Membrane Glycoproteins - physiology Rats Receptor, Anaphylatoxin C5a Receptors, Cell Surface Receptors, Complement - biosynthesis Receptors, Complement - isolation & purification Receptors, Complement - physiology Receptors, Formyl Peptide Receptors, G-Protein-Coupled Receptors, Immunologic - biosynthesis Receptors, Immunologic - isolation & purification Receptors, Immunologic - physiology Receptors, Interleukin - biosynthesis Receptors, Interleukin - isolation & purification Receptors, Interleukin - physiology Receptors, Interleukin-8A Receptors, Peptide - biosynthesis Receptors, Peptide - isolation & purification Receptors, Peptide - physiology Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Sequence Tagged Sites Thrombin - pharmacology Transfection Tumor Cells, Cultured
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