Kinetics and Crystallographic Analysis of Human Glutathione Reductase in Complex with a Xanthene Inhibitor

We have determined the crystal structure of a complex between the noncompetitive inhibitor ( K = 27 μM, K = 48 μM with respect to oxidized glutathione (GSSG) and K = 144 μM, K = 176 μM with respect to NADPH) 6-hydroxy-3-oxo-3H-xanthene-9-propionic acid (XAN) and human glutathione reductase (hGR)...

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Veröffentlicht in:	The Journal of biological chemistry 1996-04, Vol.271 (14), p.8101-8107
Hauptverfasser:	Savvides, S N, Karplus, P A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Crystallography, X-Ray Enzyme Inhibitors - chemistry Glutathione Reductase - antagonists & inhibitors Glutathione Reductase - metabolism Glutathione Reductase - ultrastructure Humans Kinetics Phenazines - chemistry Propionates - chemistry Protein Structure, Tertiary Recombinant Proteins Xanthenes - chemistry
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