Improved hemodynamic function during hypoxia with carbicarb, a new agent for the management of acidosis

Carbicarb is a mixture of Na2CO3/NaHCO3 that buffers similarly to NaHCO3, but without net generation of CO2. We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA). HLA was induced by ventilating dogs with an hypoxic gas mixture (8% O2/92% N2). Dogs with HLA (n...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1988, Vol.77 (1), p.227-233
Hauptverfasser:	BERSIN, R. M, ARIEFF, A. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis, Lactic - drug therapy Acidosis, Lactic - physiopathology Animals Bicarbonates - therapeutic use Biological and medical sciences Blood Gas Analysis Carbonates - therapeutic use Cardiac Output Cardiovascular system Dogs Drug Combinations - therapeutic use Hemodynamics - drug effects Hypoxia - drug therapy Hypoxia - physiopathology Lactates - metabolism Lactic Acid Medical sciences Miscellaneous Oxygen Consumption Pharmacology. Drug treatments Sodium - therapeutic use Sodium Bicarbonate Space life sciences
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