Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins

Low concentrations of the protein kinase C activators, bryostatins 1 and 2 synergized with recombinant B cell stimulatory factor-1 in triggering differentiation (granule enzyme expression) and cytotoxic T lymphocyte (CTL) development in naive, resting lymph node T cells. Bryostatin greatly enhances...

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Veröffentlicht in:	The Journal of immunology (1950) 1988-01, Vol.140 (2), p.433-439
Hauptverfasser:	Trenn, G, Pettit, GR, Takayama, H, Hu-Li, J, Sitkovsky, MV
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Biological and medical sciences Bryostatins Cytotoxicity, Immunologic - drug effects Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Immunosuppressive Agents - pharmacology Lactones - pharmacology Macrolides Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Modulation of the immune response (stimulation, suppression) Protein Kinase C - metabolism Spleen - cytology T-Lymphocytes, Cytotoxic - immunology
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