Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production
Purpose: The factors that lead to myointimal hyperplasia (MH) in arterial vein grafts (AVGs) are unknown. Platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) are two powerful mitogens for smooth muscle cells that have been implicated in the genesis of MH. The aim of thi...
Gespeichert in:
| Veröffentlicht in: | Journal of vascular surgery 1996-04, Vol.23 (4), p.568-575 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 575 |
|---|---|
| container_issue | 4 |
| container_start_page | 568 |
| container_title | Journal of vascular surgery |
| container_volume | 23 |
| creator | Sterpetti, Antonio V. Cucina, Alessandra Lepidi, Sandro Randone, Bruto Stipa, Francesco Aromatario, Cesare Travi, Dario D'Angelo, Luciana Santoro Cavallaro, Antonino Stipa, Sergio |
| description | Purpose: The factors that lead to myointimal hyperplasia (MH) in arterial vein grafts (AVGs) are unknown. Platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) are two powerful mitogens for smooth muscle cells that have been implicated in the genesis of MH. The aim of this study was to analyze the correlation between progression and regression of MH and production of PDGF and bFGF in experimental vein grafts.
Materials: In 64 inbred Lewis rats, a 1-cm segment of inferior vena cava was inserted at the level of the abdominal aorta. The segments of inferior vena cava were obtained from syngenic rats. In 48 rats, the AVG was explanted 3 days (n=8), 7 days (n=8), 4 weeks (n=24), and 12 weeks (n=8) after surgery. In 16 rats the vein graft was explanted after being in the arterial system for 4 weeks and was reimplanted as a venous-venous bypass in syngenic Lewis rats. Reimplanted vein grafts (RVGs) were explanted 2 weeks (n=8) and 8 weeks (n=8) later. Grafts were analyzed by light and electron microscopy, morphometry, and histochemistry, and were put in organ culture to assess PDGF and bFGF production and mitogenic activity.
Results: We observed MH formation in AVGs and MH regression in RVGs (
p |
| doi_str_mv | 10.1016/S0741-5214(96)80034-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78023433</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0741521496800346</els_id><sourcerecordid>78023433</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-d7c36ebe753603820f33627710f8d1350eefb4d6a7108d8bd737402a47a10d4f3</originalsourceid><addsrcrecordid>eNqFkc-KFDEQxoMo6-zqIyzkIOIeWpNOd5I5ybL4DxYU1HNIJ5XdSHenTTKj80o-pbUzw4AnT6GqflVfpT5CLjl7zRmXb74y1fGmb3n3ai2vNGOia-QjsuJsrRqp2foxWZ2Qp-S8lB-Mcd5rdUbOtGyVXrMV-fMlp7sMpcQ0Uzt7muEUpkCnXYpzjZMd6f1ugbyMtkRL40zhN4ZxgrlibQuYucs21EI9LDD7QnEA0hVGqI1HdAsekfSr3tNgXU15LzfgPEdDHHIacHbF4F9oyclvXMV9npEnwY4Fnh_fC_L9_btvNx-b288fPt1c3zau0xq1lBMSBlC9kEzolgUh8LeKs6A9Fz0DCEPnpcWM9nrwSqiOtbZTljPfBXFBXh7movTPDZRqplgcjKOdIW2KUZq1ohMCwf4AupxKyRDMghexeWc4Mw8emb1H5sEAs5Zm75GR2Hd5FNgME_hT19EUrL841m1xdgzZzi6WEyaYlEpoxN4eMMBjbCNkU1yE2YGPGVw1PsX_LPIXmYuymA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78023433</pqid></control><display><type>article</type><title>Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sterpetti, Antonio V. ; Cucina, Alessandra ; Lepidi, Sandro ; Randone, Bruto ; Stipa, Francesco ; Aromatario, Cesare ; Travi, Dario ; D'Angelo, Luciana Santoro ; Cavallaro, Antonino ; Stipa, Sergio</creator><creatorcontrib>Sterpetti, Antonio V. ; Cucina, Alessandra ; Lepidi, Sandro ; Randone, Bruto ; Stipa, Francesco ; Aromatario, Cesare ; Travi, Dario ; D'Angelo, Luciana Santoro ; Cavallaro, Antonino ; Stipa, Sergio</creatorcontrib><description>Purpose: The factors that lead to myointimal hyperplasia (MH) in arterial vein grafts (AVGs) are unknown. Platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) are two powerful mitogens for smooth muscle cells that have been implicated in the genesis of MH. The aim of this study was to analyze the correlation between progression and regression of MH and production of PDGF and bFGF in experimental vein grafts.
Materials: In 64 inbred Lewis rats, a 1-cm segment of inferior vena cava was inserted at the level of the abdominal aorta. The segments of inferior vena cava were obtained from syngenic rats. In 48 rats, the AVG was explanted 3 days (n=8), 7 days (n=8), 4 weeks (n=24), and 12 weeks (n=8) after surgery. In 16 rats the vein graft was explanted after being in the arterial system for 4 weeks and was reimplanted as a venous-venous bypass in syngenic Lewis rats. Reimplanted vein grafts (RVGs) were explanted 2 weeks (n=8) and 8 weeks (n=8) later. Grafts were analyzed by light and electron microscopy, morphometry, and histochemistry, and were put in organ culture to assess PDGF and bFGF production and mitogenic activity.
Results: We observed MH formation in AVGs and MH regression in RVGs (
p<0.001). PDGF and bFGF production correlated with the degree of MH (
p<0.01). Histochemistry showed PDGF and bFGF in the area of MH in AVG, which disappeared in RVG. Conditioned media from AVG had greater mitogenic activity than RVG or control veins.
Conclusions: MH formation and regression in experimental vein grafts correlate with PDGF and bFGF production.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/S0741-5214(96)80034-6</identifier><identifier>PMID: 8627890</identifier><identifier>CODEN: JVSUES</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>3T3 Cells ; Animals ; Aorta, Abdominal - surgery ; Biological and medical sciences ; Culture Media, Conditioned ; Disease Progression ; Fibroblast Growth Factor 2 - analysis ; Fibroblast Growth Factor 2 - metabolism ; Histocytochemistry ; Hyperplasia ; Male ; Medical sciences ; Mice ; Microscopy, Electron ; Mitogens - analysis ; Mitogens - metabolism ; Muscle, Smooth, Vascular - metabolism ; Muscle, Smooth, Vascular - pathology ; Organ Culture Techniques ; Platelet-Derived Growth Factor - analysis ; Platelet-Derived Growth Factor - metabolism ; Rats ; Rats, Inbred Lew ; Remission, Spontaneous ; Replantation ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tunica Intima - drug effects ; Tunica Intima - pathology ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels ; Veins - surgery ; Vena Cava, Inferior - metabolism ; Vena Cava, Inferior - pathology ; Vena Cava, Inferior - transplantation</subject><ispartof>Journal of vascular surgery, 1996-04, Vol.23 (4), p.568-575</ispartof><rights>1996 The Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-d7c36ebe753603820f33627710f8d1350eefb4d6a7108d8bd737402a47a10d4f3</citedby><cites>FETCH-LOGICAL-c488t-d7c36ebe753603820f33627710f8d1350eefb4d6a7108d8bd737402a47a10d4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0741521496800346$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3536,23910,23911,25119,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3066738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8627890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sterpetti, Antonio V.</creatorcontrib><creatorcontrib>Cucina, Alessandra</creatorcontrib><creatorcontrib>Lepidi, Sandro</creatorcontrib><creatorcontrib>Randone, Bruto</creatorcontrib><creatorcontrib>Stipa, Francesco</creatorcontrib><creatorcontrib>Aromatario, Cesare</creatorcontrib><creatorcontrib>Travi, Dario</creatorcontrib><creatorcontrib>D'Angelo, Luciana Santoro</creatorcontrib><creatorcontrib>Cavallaro, Antonino</creatorcontrib><creatorcontrib>Stipa, Sergio</creatorcontrib><title>Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>Purpose: The factors that lead to myointimal hyperplasia (MH) in arterial vein grafts (AVGs) are unknown. Platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) are two powerful mitogens for smooth muscle cells that have been implicated in the genesis of MH. The aim of this study was to analyze the correlation between progression and regression of MH and production of PDGF and bFGF in experimental vein grafts.
Materials: In 64 inbred Lewis rats, a 1-cm segment of inferior vena cava was inserted at the level of the abdominal aorta. The segments of inferior vena cava were obtained from syngenic rats. In 48 rats, the AVG was explanted 3 days (n=8), 7 days (n=8), 4 weeks (n=24), and 12 weeks (n=8) after surgery. In 16 rats the vein graft was explanted after being in the arterial system for 4 weeks and was reimplanted as a venous-venous bypass in syngenic Lewis rats. Reimplanted vein grafts (RVGs) were explanted 2 weeks (n=8) and 8 weeks (n=8) later. Grafts were analyzed by light and electron microscopy, morphometry, and histochemistry, and were put in organ culture to assess PDGF and bFGF production and mitogenic activity.
Results: We observed MH formation in AVGs and MH regression in RVGs (
p<0.001). PDGF and bFGF production correlated with the degree of MH (
p<0.01). Histochemistry showed PDGF and bFGF in the area of MH in AVG, which disappeared in RVG. Conditioned media from AVG had greater mitogenic activity than RVG or control veins.
Conclusions: MH formation and regression in experimental vein grafts correlate with PDGF and bFGF production.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Aorta, Abdominal - surgery</subject><subject>Biological and medical sciences</subject><subject>Culture Media, Conditioned</subject><subject>Disease Progression</subject><subject>Fibroblast Growth Factor 2 - analysis</subject><subject>Fibroblast Growth Factor 2 - metabolism</subject><subject>Histocytochemistry</subject><subject>Hyperplasia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>Mitogens - analysis</subject><subject>Mitogens - metabolism</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Organ Culture Techniques</subject><subject>Platelet-Derived Growth Factor - analysis</subject><subject>Platelet-Derived Growth Factor - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Remission, Spontaneous</subject><subject>Replantation</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tunica Intima - drug effects</subject><subject>Tunica Intima - pathology</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><subject>Veins - surgery</subject><subject>Vena Cava, Inferior - metabolism</subject><subject>Vena Cava, Inferior - pathology</subject><subject>Vena Cava, Inferior - transplantation</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQxoMo6-zqIyzkIOIeWpNOd5I5ybL4DxYU1HNIJ5XdSHenTTKj80o-pbUzw4AnT6GqflVfpT5CLjl7zRmXb74y1fGmb3n3ai2vNGOia-QjsuJsrRqp2foxWZ2Qp-S8lB-Mcd5rdUbOtGyVXrMV-fMlp7sMpcQ0Uzt7muEUpkCnXYpzjZMd6f1ugbyMtkRL40zhN4ZxgrlibQuYucs21EI9LDD7QnEA0hVGqI1HdAsekfSr3tNgXU15LzfgPEdDHHIacHbF4F9oyclvXMV9npEnwY4Fnh_fC_L9_btvNx-b288fPt1c3zau0xq1lBMSBlC9kEzolgUh8LeKs6A9Fz0DCEPnpcWM9nrwSqiOtbZTljPfBXFBXh7movTPDZRqplgcjKOdIW2KUZq1ohMCwf4AupxKyRDMghexeWc4Mw8emb1H5sEAs5Zm75GR2Hd5FNgME_hT19EUrL841m1xdgzZzi6WEyaYlEpoxN4eMMBjbCNkU1yE2YGPGVw1PsX_LPIXmYuymA</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Sterpetti, Antonio V.</creator><creator>Cucina, Alessandra</creator><creator>Lepidi, Sandro</creator><creator>Randone, Bruto</creator><creator>Stipa, Francesco</creator><creator>Aromatario, Cesare</creator><creator>Travi, Dario</creator><creator>D'Angelo, Luciana Santoro</creator><creator>Cavallaro, Antonino</creator><creator>Stipa, Sergio</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production</title><author>Sterpetti, Antonio V. ; Cucina, Alessandra ; Lepidi, Sandro ; Randone, Bruto ; Stipa, Francesco ; Aromatario, Cesare ; Travi, Dario ; D'Angelo, Luciana Santoro ; Cavallaro, Antonino ; Stipa, Sergio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-d7c36ebe753603820f33627710f8d1350eefb4d6a7108d8bd737402a47a10d4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Aorta, Abdominal - surgery</topic><topic>Biological and medical sciences</topic><topic>Culture Media, Conditioned</topic><topic>Disease Progression</topic><topic>Fibroblast Growth Factor 2 - analysis</topic><topic>Fibroblast Growth Factor 2 - metabolism</topic><topic>Histocytochemistry</topic><topic>Hyperplasia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microscopy, Electron</topic><topic>Mitogens - analysis</topic><topic>Mitogens - metabolism</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Organ Culture Techniques</topic><topic>Platelet-Derived Growth Factor - analysis</topic><topic>Platelet-Derived Growth Factor - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Remission, Spontaneous</topic><topic>Replantation</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tunica Intima - drug effects</topic><topic>Tunica Intima - pathology</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><topic>Veins - surgery</topic><topic>Vena Cava, Inferior - metabolism</topic><topic>Vena Cava, Inferior - pathology</topic><topic>Vena Cava, Inferior - transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sterpetti, Antonio V.</creatorcontrib><creatorcontrib>Cucina, Alessandra</creatorcontrib><creatorcontrib>Lepidi, Sandro</creatorcontrib><creatorcontrib>Randone, Bruto</creatorcontrib><creatorcontrib>Stipa, Francesco</creatorcontrib><creatorcontrib>Aromatario, Cesare</creatorcontrib><creatorcontrib>Travi, Dario</creatorcontrib><creatorcontrib>D'Angelo, Luciana Santoro</creatorcontrib><creatorcontrib>Cavallaro, Antonino</creatorcontrib><creatorcontrib>Stipa, Sergio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterpetti, Antonio V.</au><au>Cucina, Alessandra</au><au>Lepidi, Sandro</au><au>Randone, Bruto</au><au>Stipa, Francesco</au><au>Aromatario, Cesare</au><au>Travi, Dario</au><au>D'Angelo, Luciana Santoro</au><au>Cavallaro, Antonino</au><au>Stipa, Sergio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>23</volume><issue>4</issue><spage>568</spage><epage>575</epage><pages>568-575</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><coden>JVSUES</coden><abstract>Purpose: The factors that lead to myointimal hyperplasia (MH) in arterial vein grafts (AVGs) are unknown. Platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) are two powerful mitogens for smooth muscle cells that have been implicated in the genesis of MH. The aim of this study was to analyze the correlation between progression and regression of MH and production of PDGF and bFGF in experimental vein grafts.
Materials: In 64 inbred Lewis rats, a 1-cm segment of inferior vena cava was inserted at the level of the abdominal aorta. The segments of inferior vena cava were obtained from syngenic rats. In 48 rats, the AVG was explanted 3 days (n=8), 7 days (n=8), 4 weeks (n=24), and 12 weeks (n=8) after surgery. In 16 rats the vein graft was explanted after being in the arterial system for 4 weeks and was reimplanted as a venous-venous bypass in syngenic Lewis rats. Reimplanted vein grafts (RVGs) were explanted 2 weeks (n=8) and 8 weeks (n=8) later. Grafts were analyzed by light and electron microscopy, morphometry, and histochemistry, and were put in organ culture to assess PDGF and bFGF production and mitogenic activity.
Results: We observed MH formation in AVGs and MH regression in RVGs (
p<0.001). PDGF and bFGF production correlated with the degree of MH (
p<0.01). Histochemistry showed PDGF and bFGF in the area of MH in AVG, which disappeared in RVG. Conditioned media from AVG had greater mitogenic activity than RVG or control veins.
Conclusions: MH formation and regression in experimental vein grafts correlate with PDGF and bFGF production.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8627890</pmid><doi>10.1016/S0741-5214(96)80034-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0741-5214 |
| ispartof | Journal of vascular surgery, 1996-04, Vol.23 (4), p.568-575 |
| issn | 0741-5214 1097-6809 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78023433 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 3T3 Cells Animals Aorta, Abdominal - surgery Biological and medical sciences Culture Media, Conditioned Disease Progression Fibroblast Growth Factor 2 - analysis Fibroblast Growth Factor 2 - metabolism Histocytochemistry Hyperplasia Male Medical sciences Mice Microscopy, Electron Mitogens - analysis Mitogens - metabolism Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Organ Culture Techniques Platelet-Derived Growth Factor - analysis Platelet-Derived Growth Factor - metabolism Rats Rats, Inbred Lew Remission, Spontaneous Replantation Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tunica Intima - drug effects Tunica Intima - pathology Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Veins - surgery Vena Cava, Inferior - metabolism Vena Cava, Inferior - pathology Vena Cava, Inferior - transplantation |
| title | Progression and regression of myointimal hyperplasia in experimental vein grafts depends on platelet-derived growth factor and basic fibroblastic growth factor production |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T10%3A14%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Progression%20and%20regression%20of%20myointimal%20hyperplasia%20in%20experimental%20vein%20grafts%20depends%20on%20platelet-derived%20growth%20factor%20and%20basic%20fibroblastic%20growth%20factor%20production&rft.jtitle=Journal%20of%20vascular%20surgery&rft.au=Sterpetti,%20Antonio%20V.&rft.date=1996-04-01&rft.volume=23&rft.issue=4&rft.spage=568&rft.epage=575&rft.pages=568-575&rft.issn=0741-5214&rft.eissn=1097-6809&rft.coden=JVSUES&rft_id=info:doi/10.1016/S0741-5214(96)80034-6&rft_dat=%3Cproquest_cross%3E78023433%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78023433&rft_id=info:pmid/8627890&rft_els_id=S0741521496800346&rfr_iscdi=true |