Application of accelerator mass spectrometry (AMS) for high-sensitivity measurements of 14CO2 in long-term studies of fat metabolism
Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potentia...
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| Veröffentlicht in: | Applied radiation and isotopes 1996-04, Vol.47 (4), p.417-422 |
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| container_title | Applied radiation and isotopes |
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| creator | Stenström, K Leide-Svegborn, S Erlandsson, B Hellborg, R Mattsson, S Nilsson, L E Nosslin, B Skog, G Wiebert, A |
| description | Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potential of the AMS technique for the study of the long-term biokinetics of 14C-labelled pharmaceuticals. The AMS technique allows the administered activity to be reduced by several orders of magnitude without compromising the study. It may also allow studies of rare drug metabolites. |
| doi_str_mv | 10.1016/0969-8043(96)82298-6 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0969-8043 |
| ispartof | Applied radiation and isotopes, 1996-04, Vol.47 (4), p.417-422 |
| issn | 0969-8043 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Carbon Dioxide - analysis Carbon Radioisotopes Dietary Fats Humans Lipid Metabolism Male Mass Spectrometry - methods Middle Aged Time Factors Triolein - metabolism |
| title | Application of accelerator mass spectrometry (AMS) for high-sensitivity measurements of 14CO2 in long-term studies of fat metabolism |
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