Platelet Activating Factor: A Potent Constrictor of Cerebral Arterioles in Newborn Pigs

This study characterized the nature of the response to platelet activating factor (PAF) in the cerebral microcirculation of the newborn pig. Pig arterioles were observed directly using a closed cranial window in chloralose-anesthetized piglets. Topical application of 10-100 ng/ml PAF produced dose-d...

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Veröffentlicht in:	Circulation research 1988-01, Vol.62 (1), p.1-8
Hauptverfasser:	Armstead, William M, Pourcyrous, Massroor, Mirro, Robert, Leffler, Charles W, Busija, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Animals, Newborn Arterioles - drug effects Biological and medical sciences Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - drug effects Chromones - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Norepinephrine - pharmacology Platelet Activating Factor - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Reference Values Swine Vertebrates: nervous system and sense organs
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