Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate

Immunologic activation of purified human lung mast cells (HLMC) and basophils with anti-IgE induced histamine release but failed to elicit any changes in cAMP levels. In contrast, histamine release and monophasic rises in cAMP were observed in both rat peritoneal mast cells (RPMC) challenged with co...

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Veröffentlicht in:	The Journal of immunology (1950) 1988-01, Vol.140 (2), p.571-579
Hauptverfasser:	Peachell, PT, MacGlashan, DW, Jr, Lichtenstein, LM, Schleimer, RP
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Animals Basophils - immunology Basophils - metabolism Biological and medical sciences Colforsin - pharmacology Cyclic AMP - metabolism Cyclic AMP - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Histamine Release - drug effects Humans Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunobiology Isoproterenol - pharmacology Kinetics Lung - cytology Male Mast Cells - immunology Mast Cells - metabolism Mice Rats Rats, Inbred Strains Reaction mechanisms, antibodies, chemical mediators
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