The effect of antisecretory factor on the permeability of nerve cell membrane to chloride ion
The antisecretory factor (ASF) is a hormone-like protein (m.w. 60,000) that most effectively counteracts hypersecretion in vivo in the small intestine of pigs and rats. The present report demonstrate that 10(-13) moles of ASF inhibits significantly the 36Cl- permeation through the isolated neuronal...
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| Veröffentlicht in: | Pflügers Archiv 1987-12, Vol.410 (6), p.648-651 |
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| container_title | Pflügers Archiv |
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| creator | LANGE, S LONNROTH, I PALM, A HYDEN, H |
| description | The antisecretory factor (ASF) is a hormone-like protein (m.w. 60,000) that most effectively counteracts hypersecretion in vivo in the small intestine of pigs and rats. The present report demonstrate that 10(-13) moles of ASF inhibits significantly the 36Cl- permeation through the isolated neuronal plasma membrane of Deiters' cells in rabbits. This effect was enhanced by 0.2 mM gamma-aminobutyric acid (GABA), and quenched by the addition of anti-ASF immunoglobulins; pretreatment of the neuronal membrane with nipecotic acid (10(-6) M) or with bicuculline (10(-3) M) abolished the ASF action whilst picrotoxin (10(-4) M) pretreatment left the inhibitory effect of ASF unaffected. The results suggest that ASF blocks chloride channels in neuronal membranes, including those channels activated by GABA. |
| doi_str_mv | 10.1007/BF00581326 |
| format | Article |
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The present report demonstrate that 10(-13) moles of ASF inhibits significantly the 36Cl- permeation through the isolated neuronal plasma membrane of Deiters' cells in rabbits. This effect was enhanced by 0.2 mM gamma-aminobutyric acid (GABA), and quenched by the addition of anti-ASF immunoglobulins; pretreatment of the neuronal membrane with nipecotic acid (10(-6) M) or with bicuculline (10(-3) M) abolished the ASF action whilst picrotoxin (10(-4) M) pretreatment left the inhibitory effect of ASF unaffected. 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The present report demonstrate that 10(-13) moles of ASF inhibits significantly the 36Cl- permeation through the isolated neuronal plasma membrane of Deiters' cells in rabbits. This effect was enhanced by 0.2 mM gamma-aminobutyric acid (GABA), and quenched by the addition of anti-ASF immunoglobulins; pretreatment of the neuronal membrane with nipecotic acid (10(-6) M) or with bicuculline (10(-3) M) abolished the ASF action whilst picrotoxin (10(-4) M) pretreatment left the inhibitory effect of ASF unaffected. The results suggest that ASF blocks chloride channels in neuronal membranes, including those channels activated by GABA.</description><subject>Animals</subject><subject>Antidiarrheals - pharmacology</subject><subject>Applied sciences</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Chlorides - pharmacokinetics</subject><subject>Exact sciences and technology</subject><subject>In Vitro Techniques</subject><subject>Neuroglia - drug effects</subject><subject>Neuroglia - metabolism</subject><subject>Neuropeptides - pharmacology</subject><subject>Other techniques and industries</subject><subject>Rabbits</subject><issn>0031-6768</issn><issn>1432-2013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAYhoMoc04v3oUcxINQ_fKjTXrU4VQYeNlVSpp-YZG2mUkn7L-3Y0NP7-F9eHl5CLlm8MAA1OPzAiDXTPDihEyZFDzjwMQpmQIIlhWq0OfkIqUvAOBS8wmZCClLDTAln6s1UnQO7UCDo6YffEIbcQhxR52xY9LQ02GkNhg7NLVv_bDbsz3GH6QW25Z22NXR9EiHQO26DdE3SH3oL8mZM23Cq2POyGrxspq_ZcuP1_f50zKzgrEh08hU6bisnRPK5Vw5rnKlrG6YrIVtkNe2ZrpRQpZOos1NbhmC4qyQ4JiYkbvD7CaG7y2moep82h8bL4VtqpQedZScj-D9AbQxpBTRVZvoOxN3FYNqr7L6VznCN8fVbd1h84ce3Y397bE3yZrWjQKsT3-YAiWLvBS_HUR6xQ</recordid><startdate>19871201</startdate><enddate>19871201</enddate><creator>LANGE, S</creator><creator>LONNROTH, I</creator><creator>PALM, A</creator><creator>HYDEN, H</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871201</creationdate><title>The effect of antisecretory factor on the permeability of nerve cell membrane to chloride ion</title><author>LANGE, S ; LONNROTH, I ; PALM, A ; HYDEN, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-8e179f24bff37f527f27577c8d14b3cde2bcb18d7349f4ec5a5c1e0721640f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antidiarrheals - pharmacology</topic><topic>Applied sciences</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>Chlorides - pharmacokinetics</topic><topic>Exact sciences and technology</topic><topic>In Vitro Techniques</topic><topic>Neuroglia - drug effects</topic><topic>Neuroglia - metabolism</topic><topic>Neuropeptides - pharmacology</topic><topic>Other techniques and industries</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANGE, S</creatorcontrib><creatorcontrib>LONNROTH, I</creatorcontrib><creatorcontrib>PALM, A</creatorcontrib><creatorcontrib>HYDEN, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pflügers Archiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANGE, S</au><au>LONNROTH, I</au><au>PALM, A</au><au>HYDEN, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of antisecretory factor on the permeability of nerve cell membrane to chloride ion</atitle><jtitle>Pflügers Archiv</jtitle><addtitle>Pflugers Arch</addtitle><date>1987-12-01</date><risdate>1987</risdate><volume>410</volume><issue>6</issue><spage>648</spage><epage>651</epage><pages>648-651</pages><issn>0031-6768</issn><eissn>1432-2013</eissn><coden>PFLABK</coden><abstract>The antisecretory factor (ASF) is a hormone-like protein (m.w. 60,000) that most effectively counteracts hypersecretion in vivo in the small intestine of pigs and rats. The present report demonstrate that 10(-13) moles of ASF inhibits significantly the 36Cl- permeation through the isolated neuronal plasma membrane of Deiters' cells in rabbits. This effect was enhanced by 0.2 mM gamma-aminobutyric acid (GABA), and quenched by the addition of anti-ASF immunoglobulins; pretreatment of the neuronal membrane with nipecotic acid (10(-6) M) or with bicuculline (10(-3) M) abolished the ASF action whilst picrotoxin (10(-4) M) pretreatment left the inhibitory effect of ASF unaffected. The results suggest that ASF blocks chloride channels in neuronal membranes, including those channels activated by GABA.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3449800</pmid><doi>10.1007/BF00581326</doi><tpages>4</tpages></addata></record> |
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| ispartof | Pflügers Archiv, 1987-12, Vol.410 (6), p.648-651 |
| issn | 0031-6768 1432-2013 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antidiarrheals - pharmacology Applied sciences Cell Membrane Permeability - drug effects Chlorides - pharmacokinetics Exact sciences and technology In Vitro Techniques Neuroglia - drug effects Neuroglia - metabolism Neuropeptides - pharmacology Other techniques and industries Rabbits |
| title | The effect of antisecretory factor on the permeability of nerve cell membrane to chloride ion |
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