Tolerance of Kenyan Schistosoma mansoni to oxamniquine
Although 30 mg/kg oxamniquine produced high levels (85·5 to 99·5%) of egg reduction in Kenyan children infected with Schistosoma mansoni after a single oral treatment, cure rates from children at Mwea in Kirinyaga district were lower than those from Machakos (58% v. 74%). Redosing uncured children c...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 1987-01, Vol.81 (5), p.782-785 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Coles, G.C. Mutahi, W.T. Kinoti, G.K. Bruce, J.I. Katz, N. |
| description | Although 30 mg/kg oxamniquine produced high levels (85·5 to 99·5%) of egg reduction in Kenyan children infected with
Schistosoma mansoni after a single oral treatment, cure rates from children at Mwea in Kirinyaga district were lower than those from Machakos (58% v. 74%). Redosing uncured children confirmed this lower cure rate (36% v. 83%). Isolates from infected children were passaged into mice and dosed with oxamniquine. Lower than expected reductions in worm numbers were obtained, suggesting that oxamniquine tolerant
S. mansoni are present in the normal worm population in Kenya. It is concluded that mass use of oxamniquine at 30 mg/kg may produce problems of drug resistance. |
| doi_str_mv | 10.1016/0035-9203(87)90032-0 |
| format | Article |
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S. mansoni are present in the normal worm population in Kenya. It is concluded that mass use of oxamniquine at 30 mg/kg may produce problems of drug resistance.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diseases caused by trematodes</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Kenya</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitroquinolines - therapeutic use</subject><subject>Oxamniquine - administration & dosage</subject><subject>Oxamniquine - therapeutic use</subject><subject>Parasitic diseases</subject><subject>Pharmacology. 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Schistosoma mansoni after a single oral treatment, cure rates from children at Mwea in Kirinyaga district were lower than those from Machakos (58% v. 74%). Redosing uncured children confirmed this lower cure rate (36% v. 83%). Isolates from infected children were passaged into mice and dosed with oxamniquine. Lower than expected reductions in worm numbers were obtained, suggesting that oxamniquine tolerant
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| ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987-01, Vol.81 (5), p.782-785 |
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| subjects | Administration, Oral Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Child Diseases caused by trematodes Dose-Response Relationship, Drug Drug Resistance Female Helminthic diseases Humans Infectious diseases Kenya Male Medical sciences Nitroquinolines - therapeutic use Oxamniquine - administration & dosage Oxamniquine - therapeutic use Parasitic diseases Pharmacology. Drug treatments Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Schistosoma mansoni - drug effects Schistosomiases Schistosomiasis mansoni - drug therapy Schistosomiasis mansoni - epidemiology Specific populations (family, woman, child, elderly...) Tropical medicine |
| title | Tolerance of Kenyan Schistosoma mansoni to oxamniquine |
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