Impaired wound healing in mice with a disrupted plasminogen gene
Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds i...
Gespeichert in:
| Veröffentlicht in: | Nature medicine 1996-03, Vol.2 (3), p.287-292 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 292 |
|---|---|
| container_issue | 3 |
| container_start_page | 287 |
| container_title | Nature medicine |
| container_volume | 2 |
| creator | Rømer, John Bugge, Thomas H. Fyke, Charles Lund, Leif R. Flick, Matthew J. Degen, Jay L. Danø, Keld |
| description | Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in Plg by targeted gene disruption. The results demonstrate that Plg is required for normal repair of skin wounds in mice and support the assumption that it also plays a central role in other disease processes involving extracellular matrix degradation, such as cancer invasion. |
| doi_str_mv | 10.1038/nm0396-287 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78010620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78010620</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-dcc4b8ce2bf5e35d97e27e7a7a8118880e9dafaecddcc95b29fb430f4f163f6e3</originalsourceid><addsrcrecordid>eNqFkEtLxDAUhYMoo45u3AtduVCqSdM8ulMGHwMDbhTchbS5ncnQpjVpGfz3Rjq4ElxczoXzcRYfQhcE3xJM5Z1rMS14mklxgE4Iy3lKBP44jD8WMpUF48foNIQtxphiVszQTHKSZRk_QffLttfWg0l23ehMsgHdWLdOrEtaW0Gys8Mm0YmxwY_9ELG-0aG1rluDS-LBGTqqdRPgfJ9z9P70-LZ4SVevz8vFwyqtaF4MqamqvJQVZGXNgDJTCMgECC20JERKiaEwutZQmUgWrMyKuswprvOacFpzoHN0Ne32vvscIQyqtaGCptEOujEoITHBPMP_goRxynDOIng9gZXvQvBQq97bVvsvRbD68aomryp6jfDlfnUsWzC_6F5k7G-mPsTGrcGrbTd6F438tfYNVd-B1Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15635045</pqid></control><display><type>article</type><title>Impaired wound healing in mice with a disrupted plasminogen gene</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><creator>Rømer, John ; Bugge, Thomas H. ; Fyke, Charles ; Lund, Leif R. ; Flick, Matthew J. ; Degen, Jay L. ; Danø, Keld</creator><creatorcontrib>Rømer, John ; Bugge, Thomas H. ; Fyke, Charles ; Lund, Leif R. ; Flick, Matthew J. ; Degen, Jay L. ; Danø, Keld</creatorcontrib><description>Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in Plg by targeted gene disruption. The results demonstrate that Plg is required for normal repair of skin wounds in mice and support the assumption that it also plays a central role in other disease processes involving extracellular matrix degradation, such as cancer invasion.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm0396-287</identifier><identifier>PMID: 8612226</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Endopeptidases - metabolism ; Extracellular Matrix - pathology ; Gene Expression Regulation ; Gene Targeting ; Immunohistochemistry ; In Situ Hybridization ; Infectious Diseases ; Metabolic Diseases ; Mice ; Mice, Mutant Strains ; Molecular Medicine ; Neurosciences ; Plasminogen - genetics ; Plasminogen - physiology ; Skin - injuries ; Skin - metabolism ; Skin - pathology ; Wound Healing - genetics ; Wound Healing - physiology</subject><ispartof>Nature medicine, 1996-03, Vol.2 (3), p.287-292</ispartof><rights>Springer Nature America, Inc. 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-dcc4b8ce2bf5e35d97e27e7a7a8118880e9dafaecddcc95b29fb430f4f163f6e3</citedby><cites>FETCH-LOGICAL-c349t-dcc4b8ce2bf5e35d97e27e7a7a8118880e9dafaecddcc95b29fb430f4f163f6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm0396-287$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm0396-287$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8612226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rømer, John</creatorcontrib><creatorcontrib>Bugge, Thomas H.</creatorcontrib><creatorcontrib>Fyke, Charles</creatorcontrib><creatorcontrib>Lund, Leif R.</creatorcontrib><creatorcontrib>Flick, Matthew J.</creatorcontrib><creatorcontrib>Degen, Jay L.</creatorcontrib><creatorcontrib>Danø, Keld</creatorcontrib><title>Impaired wound healing in mice with a disrupted plasminogen gene</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in Plg by targeted gene disruption. The results demonstrate that Plg is required for normal repair of skin wounds in mice and support the assumption that it also plays a central role in other disease processes involving extracellular matrix degradation, such as cancer invasion.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Endopeptidases - metabolism</subject><subject>Extracellular Matrix - pathology</subject><subject>Gene Expression Regulation</subject><subject>Gene Targeting</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Infectious Diseases</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>Plasminogen - genetics</subject><subject>Plasminogen - physiology</subject><subject>Skin - injuries</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Wound Healing - genetics</subject><subject>Wound Healing - physiology</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoo45u3AtduVCqSdM8ulMGHwMDbhTchbS5ncnQpjVpGfz3Rjq4ElxczoXzcRYfQhcE3xJM5Z1rMS14mklxgE4Iy3lKBP44jD8WMpUF48foNIQtxphiVszQTHKSZRk_QffLttfWg0l23ehMsgHdWLdOrEtaW0Gys8Mm0YmxwY_9ELG-0aG1rluDS-LBGTqqdRPgfJ9z9P70-LZ4SVevz8vFwyqtaF4MqamqvJQVZGXNgDJTCMgECC20JERKiaEwutZQmUgWrMyKuswprvOacFpzoHN0Ne32vvscIQyqtaGCptEOujEoITHBPMP_goRxynDOIng9gZXvQvBQq97bVvsvRbD68aomryp6jfDlfnUsWzC_6F5k7G-mPsTGrcGrbTd6F438tfYNVd-B1Q</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Rømer, John</creator><creator>Bugge, Thomas H.</creator><creator>Fyke, Charles</creator><creator>Lund, Leif R.</creator><creator>Flick, Matthew J.</creator><creator>Degen, Jay L.</creator><creator>Danø, Keld</creator><general>Nature Publishing Group US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Impaired wound healing in mice with a disrupted plasminogen gene</title><author>Rømer, John ; Bugge, Thomas H. ; Fyke, Charles ; Lund, Leif R. ; Flick, Matthew J. ; Degen, Jay L. ; Danø, Keld</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-dcc4b8ce2bf5e35d97e27e7a7a8118880e9dafaecddcc95b29fb430f4f163f6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Endopeptidases - metabolism</topic><topic>Extracellular Matrix - pathology</topic><topic>Gene Expression Regulation</topic><topic>Gene Targeting</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Infectious Diseases</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Molecular Medicine</topic><topic>Neurosciences</topic><topic>Plasminogen - genetics</topic><topic>Plasminogen - physiology</topic><topic>Skin - injuries</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Wound Healing - genetics</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rømer, John</creatorcontrib><creatorcontrib>Bugge, Thomas H.</creatorcontrib><creatorcontrib>Fyke, Charles</creatorcontrib><creatorcontrib>Lund, Leif R.</creatorcontrib><creatorcontrib>Flick, Matthew J.</creatorcontrib><creatorcontrib>Degen, Jay L.</creatorcontrib><creatorcontrib>Danø, Keld</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rømer, John</au><au>Bugge, Thomas H.</au><au>Fyke, Charles</au><au>Lund, Leif R.</au><au>Flick, Matthew J.</au><au>Degen, Jay L.</au><au>Danø, Keld</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired wound healing in mice with a disrupted plasminogen gene</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>2</volume><issue>3</issue><spage>287</spage><epage>292</epage><pages>287-292</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Activation of plasminogen (Plg) has been proposed to play a role in proteolytic degradation of extracellular matrices in tissue remodeling events, including wound healing. However, there has been no definitive proof of involvement of Plg in such processes. We now report that healing of skin wounds is severely impaired in mice made deficient in Plg by targeted gene disruption. The results demonstrate that Plg is required for normal repair of skin wounds in mice and support the assumption that it also plays a central role in other disease processes involving extracellular matrix degradation, such as cancer invasion.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>8612226</pmid><doi>10.1038/nm0396-287</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 1996-03, Vol.2 (3), p.287-292 |
| issn | 1078-8956 1546-170X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78010620 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cancer Research Endopeptidases - metabolism Extracellular Matrix - pathology Gene Expression Regulation Gene Targeting Immunohistochemistry In Situ Hybridization Infectious Diseases Metabolic Diseases Mice Mice, Mutant Strains Molecular Medicine Neurosciences Plasminogen - genetics Plasminogen - physiology Skin - injuries Skin - metabolism Skin - pathology Wound Healing - genetics Wound Healing - physiology |
| title | Impaired wound healing in mice with a disrupted plasminogen gene |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A21%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impaired%20wound%20healing%20in%20mice%20with%20a%20disrupted%20plasminogen%20gene&rft.jtitle=Nature%20medicine&rft.au=R%C3%B8mer,%20John&rft.date=1996-03-01&rft.volume=2&rft.issue=3&rft.spage=287&rft.epage=292&rft.pages=287-292&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm0396-287&rft_dat=%3Cproquest_cross%3E78010620%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15635045&rft_id=info:pmid/8612226&rfr_iscdi=true |