Himastatin, a New Antitumor Antibiotic from Streptomyces hygroscopicus: III. Structural Elucidation

The structure of the antitumor antibiotic himastatin was determined using a combination of spectroscopic and chemical degradation techniques. Himastatin is a unique dimeric cyclohexadepsipeptide joined through a biphenyl linkage between two oxidized tryptophan units. The gross structure of the dimer...

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Veröffentlicht in:	Journal of antibiotics 1996/03/25, Vol.49(3), pp.299-311
Hauptverfasser:	LEET, JOHN E., SCHROEDER, DANIEL R., GOLIK, JERZY, MATSON, JAMES A., DOYLE, TERRENCE W., LAM, KIN S., HILL, SUSAN E., LEE, MIKE S., WHITNEY, JEFFREY L., KRISHNAN, BALA S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibiotics, Antineoplastic - biosynthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Chemotherapy Humans Magnetic Resonance Spectroscopy Medical sciences Molecular Sequence Data Molecular Structure Peptides, Cyclic - biosynthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet Stereoisomerism Streptomyces - metabolism Tumor Cells, Cultured
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