Critical protective role of mast cells in a model of acute septic peritonitis
MAST cells play a detrimental role in IgE-dependent allergic reactions. In contrast, a protective function for mast cells has been proposed on the basis of some worm infection models. No reports exist on the in vivo significance of these cells in bacterial infections 1,2 . Here we use congenitally m...
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| Veröffentlicht in: | Nature (London) 1996-05, Vol.381 (6577), p.75-77 |
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| creator | Echtenacher, Bernd Männel, Daniela N. Hültner, Lothar |
| description | MAST cells play a detrimental role in IgE-dependent allergic reactions. In contrast, a protective function for mast cells has been proposed on the basis of some worm infection models. No reports exist on the
in vivo
significance of these cells in bacterial infections
1,2
. Here we use congenitally mast-cell-deficient W/W
v
mice and normal +/+ littermates
3,4
to analyse the role of mast cells in a model of acute septic peritonitis (caecum ligation and puncture (CLP)). Following CLP, W/W
v
mice showed a significantly increased mortality compared to +/+ mice. The selective reconstitution of W/W
v
mice with cultured +/+ mast cells substantially protected them from the lethal effects of CLP, whereas an anti-tumour-necrosis-factor (TNF) antibody injected immediately after CLP completely suppressed this protection. Our results reveal a previously unrecognized protective role of mast cells and mast-cell-derived TNF in acute bacterial peritonitis. |
| doi_str_mv | 10.1038/381075a0 |
| format | Article |
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in vivo
significance of these cells in bacterial infections
1,2
. Here we use congenitally mast-cell-deficient W/W
v
mice and normal +/+ littermates
3,4
to analyse the role of mast cells in a model of acute septic peritonitis (caecum ligation and puncture (CLP)). Following CLP, W/W
v
mice showed a significantly increased mortality compared to +/+ mice. The selective reconstitution of W/W
v
mice with cultured +/+ mast cells substantially protected them from the lethal effects of CLP, whereas an anti-tumour-necrosis-factor (TNF) antibody injected immediately after CLP completely suppressed this protection. Our results reveal a previously unrecognized protective role of mast cells and mast-cell-derived TNF in acute bacterial peritonitis.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/381075a0</identifier><identifier>PMID: 8609992</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acute Disease ; Analysis of the immune response. Humoral and cellular immunity ; Animals ; Antibody production ; Bacteria ; Bacterial diseases ; Biological and medical sciences ; Bone Marrow Cells ; Caecum ; Cells, Cultured ; Cellular biology ; Disease Models, Animal ; Erythrocyte Count ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Hematocrit ; Humanities and Social Sciences ; Immunobiology ; Lethal effects ; letter ; Mast Cells - immunology ; Mast Cells - transplantation ; Mice ; Mice, Inbred C57BL ; multidisciplinary ; Peritonitis - immunology ; Rodents ; Science ; Science (multidisciplinary) ; Sepsis - immunology ; Tumor Necrosis Factor-alpha - pharmacology ; Tumors</subject><ispartof>Nature (London), 1996-05, Vol.381 (6577), p.75-77</ispartof><rights>Springer Nature Limited 1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. May 2, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-41bf4b4b3456f22e42010e749322e4da8cd19951e93cd96dbb405bcc73753bfa3</citedby><cites>FETCH-LOGICAL-c527t-41bf4b4b3456f22e42010e749322e4da8cd19951e93cd96dbb405bcc73753bfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/381075a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/381075a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3074277$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8609992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Echtenacher, Bernd</creatorcontrib><creatorcontrib>Männel, Daniela N.</creatorcontrib><creatorcontrib>Hültner, Lothar</creatorcontrib><title>Critical protective role of mast cells in a model of acute septic peritonitis</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>MAST cells play a detrimental role in IgE-dependent allergic reactions. In contrast, a protective function for mast cells has been proposed on the basis of some worm infection models. No reports exist on the
in vivo
significance of these cells in bacterial infections
1,2
. Here we use congenitally mast-cell-deficient W/W
v
mice and normal +/+ littermates
3,4
to analyse the role of mast cells in a model of acute septic peritonitis (caecum ligation and puncture (CLP)). Following CLP, W/W
v
mice showed a significantly increased mortality compared to +/+ mice. The selective reconstitution of W/W
v
mice with cultured +/+ mast cells substantially protected them from the lethal effects of CLP, whereas an anti-tumour-necrosis-factor (TNF) antibody injected immediately after CLP completely suppressed this protection. Our results reveal a previously unrecognized protective role of mast cells and mast-cell-derived TNF in acute bacterial peritonitis.</description><subject>Acute Disease</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Antibody production</subject><subject>Bacteria</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Cells</subject><subject>Caecum</subject><subject>Cells, Cultured</subject><subject>Cellular biology</subject><subject>Disease Models, Animal</subject><subject>Erythrocyte Count</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Hematocrit</subject><subject>Humanities and Social Sciences</subject><subject>Immunobiology</subject><subject>Lethal effects</subject><subject>letter</subject><subject>Mast Cells - immunology</subject><subject>Mast Cells - transplantation</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>multidisciplinary</subject><subject>Peritonitis - immunology</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sepsis - immunology</subject><subject>Tumor Necrosis Factor-alpha - pharmacology</subject><subject>Tumors</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtLHEEUhYug6PgA_0CgEAlx0fHWu2opQ4yC4iaum-rq29LSj0lVt-C_t4aZGDCLWV0u56tzD3UIOWPwg4GwV8IyMMrDF7Jg0uhCamv2yAKA2wKs0IfkKKUXAFDMyANyYDU45_iCPCxjO7XBd3QVxwnD1L4ijWOHdGxo79NEA3Zdou1APe3HGru14MM8IU24yk_pCrPFOGSbdEL2G98lPN3OY_J08_P38ra4f_x1t7y-L4LiZiokqxpZyUpIpRvOUXJggEY6sV5qb0PNnFMMnQi103VVSVBVCEYYJarGi2PybeObQ_-ZMU1l36Z1UD_gOKfSWACnQe4EhWJcWmA7Qc6YZULrnSAz-Swom8HzT-DLOMchf0vJQUrtnFUZ-r6BQhxTitiUq9j2Pr6VDMp1s-XfZjP6des3Vz3WH-C2yqxfbHWfcp9N9ENo0wcmwEhuTMYuN1jKyvCM8V-s_06-A3VYtR0</recordid><startdate>19960502</startdate><enddate>19960502</enddate><creator>Echtenacher, Bernd</creator><creator>Männel, Daniela N.</creator><creator>Hültner, Lothar</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19960502</creationdate><title>Critical protective role of mast cells in a model of acute septic peritonitis</title><author>Echtenacher, Bernd ; Männel, Daniela N. ; Hültner, Lothar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-41bf4b4b3456f22e42010e749322e4da8cd19951e93cd96dbb405bcc73753bfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acute Disease</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Antibody production</topic><topic>Bacteria</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Cells</topic><topic>Caecum</topic><topic>Cells, Cultured</topic><topic>Cellular biology</topic><topic>Disease Models, Animal</topic><topic>Erythrocyte Count</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Hematocrit</topic><topic>Humanities and Social Sciences</topic><topic>Immunobiology</topic><topic>Lethal effects</topic><topic>letter</topic><topic>Mast Cells - immunology</topic><topic>Mast Cells - transplantation</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>multidisciplinary</topic><topic>Peritonitis - immunology</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sepsis - immunology</topic><topic>Tumor Necrosis Factor-alpha - pharmacology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Echtenacher, Bernd</creatorcontrib><creatorcontrib>Männel, Daniela N.</creatorcontrib><creatorcontrib>Hültner, Lothar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Echtenacher, Bernd</au><au>Männel, Daniela N.</au><au>Hültner, Lothar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Critical protective role of mast cells in a model of acute septic peritonitis</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-05-02</date><risdate>1996</risdate><volume>381</volume><issue>6577</issue><spage>75</spage><epage>77</epage><pages>75-77</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>MAST cells play a detrimental role in IgE-dependent allergic reactions. In contrast, a protective function for mast cells has been proposed on the basis of some worm infection models. No reports exist on the
in vivo
significance of these cells in bacterial infections
1,2
. Here we use congenitally mast-cell-deficient W/W
v
mice and normal +/+ littermates
3,4
to analyse the role of mast cells in a model of acute septic peritonitis (caecum ligation and puncture (CLP)). Following CLP, W/W
v
mice showed a significantly increased mortality compared to +/+ mice. The selective reconstitution of W/W
v
mice with cultured +/+ mast cells substantially protected them from the lethal effects of CLP, whereas an anti-tumour-necrosis-factor (TNF) antibody injected immediately after CLP completely suppressed this protection. Our results reveal a previously unrecognized protective role of mast cells and mast-cell-derived TNF in acute bacterial peritonitis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8609992</pmid><doi>10.1038/381075a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1996-05, Vol.381 (6577), p.75-77 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Acute Disease Analysis of the immune response. Humoral and cellular immunity Animals Antibody production Bacteria Bacterial diseases Biological and medical sciences Bone Marrow Cells Caecum Cells, Cultured Cellular biology Disease Models, Animal Erythrocyte Count Fundamental and applied biological sciences. Psychology Fundamental immunology Hematocrit Humanities and Social Sciences Immunobiology Lethal effects letter Mast Cells - immunology Mast Cells - transplantation Mice Mice, Inbred C57BL multidisciplinary Peritonitis - immunology Rodents Science Science (multidisciplinary) Sepsis - immunology Tumor Necrosis Factor-alpha - pharmacology Tumors |
| title | Critical protective role of mast cells in a model of acute septic peritonitis |
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