Placental transfer of milrinone in the nonhuman primate (baboon)
Milrinone is an inotropic agent for short-term intravenous use in the management of congestive heart failure. The purpose of this article is to question the previously reported lack of transplacental transfer of milrinone. Loading and continuous intravenous doses, considered to be therapeutic in hum...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1996-03, Vol.174 (3), p.895-896 |
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| container_end_page | 896 |
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| container_issue | 3 |
| container_start_page | 895 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 174 |
| creator | Atkinson, Bill D. Fishburne, John I. Hales, Kurt A. Levy, Gerrold H. Rayburn, William F. |
| description | Milrinone is an inotropic agent for short-term intravenous use in the management of congestive heart failure. The purpose of this article is to question the previously reported lack of transplacental transfer of milrinone. Loading and continuous intravenous doses, considered to be therapeutic in humans, were administered to four near-term baboons. Transplacental passage was documented, with a maternal/fetal serum ratio of approximately 4:1 found during the 3 hours of infusion. (A
M J O
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YNECOL 1996;174:895-6.) |
| doi_str_mv | 10.1016/S0002-9378(96)70321-6 |
| format | Article |
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M J O
BSTET G
YNECOL 1996;174:895-6.)</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/S0002-9378(96)70321-6</identifier><identifier>PMID: 8633664</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Animals ; baboon ; Biological and medical sciences ; Cardiotonic agents ; Cardiotonic Agents - administration & dosage ; Cardiotonic Agents - blood ; Cardiotonic Agents - pharmacology ; Cardiovascular system ; Female ; Fetal Blood - metabolism ; Infusions, Intravenous ; Medical sciences ; Milrinone ; Papio ; Pharmacology. Drug treatments ; Placenta ; Placenta - metabolism ; Pregnancy ; Pyridones - administration & dosage ; Pyridones - blood ; Pyridones - pharmacokinetics</subject><ispartof>American journal of obstetrics and gynecology, 1996-03, Vol.174 (3), p.895-896</ispartof><rights>1996 Mosby, Inc.</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-2f6490dc3af49b6b1461ec77452a9c8ff2cdcf6ec66182e3f31ecfef5143a3cd3</citedby><cites>FETCH-LOGICAL-c389t-2f6490dc3af49b6b1461ec77452a9c8ff2cdcf6ec66182e3f31ecfef5143a3cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937896703216$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3040316$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8633664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atkinson, Bill D.</creatorcontrib><creatorcontrib>Fishburne, John I.</creatorcontrib><creatorcontrib>Hales, Kurt A.</creatorcontrib><creatorcontrib>Levy, Gerrold H.</creatorcontrib><creatorcontrib>Rayburn, William F.</creatorcontrib><title>Placental transfer of milrinone in the nonhuman primate (baboon)</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Milrinone is an inotropic agent for short-term intravenous use in the management of congestive heart failure. The purpose of this article is to question the previously reported lack of transplacental transfer of milrinone. Loading and continuous intravenous doses, considered to be therapeutic in humans, were administered to four near-term baboons. Transplacental passage was documented, with a maternal/fetal serum ratio of approximately 4:1 found during the 3 hours of infusion. (A
M J O
BSTET G
YNECOL 1996;174:895-6.)</description><subject>Animals</subject><subject>baboon</subject><subject>Biological and medical sciences</subject><subject>Cardiotonic agents</subject><subject>Cardiotonic Agents - administration & dosage</subject><subject>Cardiotonic Agents - blood</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Cardiovascular system</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Infusions, Intravenous</subject><subject>Medical sciences</subject><subject>Milrinone</subject><subject>Papio</subject><subject>Pharmacology. Drug treatments</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pyridones - administration & dosage</subject><subject>Pyridones - blood</subject><subject>Pyridones - pharmacokinetics</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMoc05_wqAXIttFNWnatLlSGX7BQEG9Dml6wiJtMpNW8N_bbmW3Xp0c3uecHB6E5gRfE0zYzTvGOIk5zYsFZ8sc04TE7AhNCeZ5zApWHKPpATlFZyF8DW3CkwmaFIxSxtIpunurpQLbyjpqvbRBg4-cjhpTe2OdhcjYqN1A1L83XSNttPWmkS1Ei1KWztnlOTrRsg5wMdYZ-nx8-Fg9x-vXp5fV_TpWtOBtnGiWclwpKnXKS1aSlBFQeZ5mieSq0DpRldIMFGOkSIBq2scadEZSKqmq6Axd7fduvfvuILSiMUFBXUsLrgsiLzDmGac9mO1B5V0IHrTYnex_BcFiMCd25sSgRXAmduYE6-fm4wdd2UB1mBpV9fnlmMugZK17W8qEA0ZxiikZ1tzuMehl_BjwIigDVkFlPKhWVM78c8gfHgSKVA</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>Atkinson, Bill D.</creator><creator>Fishburne, John I.</creator><creator>Hales, Kurt A.</creator><creator>Levy, Gerrold H.</creator><creator>Rayburn, William F.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Placental transfer of milrinone in the nonhuman primate (baboon)</title><author>Atkinson, Bill D. ; Fishburne, John I. ; Hales, Kurt A. ; Levy, Gerrold H. ; Rayburn, William F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-2f6490dc3af49b6b1461ec77452a9c8ff2cdcf6ec66182e3f31ecfef5143a3cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>baboon</topic><topic>Biological and medical sciences</topic><topic>Cardiotonic agents</topic><topic>Cardiotonic Agents - administration & dosage</topic><topic>Cardiotonic Agents - blood</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Cardiovascular system</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Infusions, Intravenous</topic><topic>Medical sciences</topic><topic>Milrinone</topic><topic>Papio</topic><topic>Pharmacology. Drug treatments</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Pyridones - administration & dosage</topic><topic>Pyridones - blood</topic><topic>Pyridones - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atkinson, Bill D.</creatorcontrib><creatorcontrib>Fishburne, John I.</creatorcontrib><creatorcontrib>Hales, Kurt A.</creatorcontrib><creatorcontrib>Levy, Gerrold H.</creatorcontrib><creatorcontrib>Rayburn, William F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atkinson, Bill D.</au><au>Fishburne, John I.</au><au>Hales, Kurt A.</au><au>Levy, Gerrold H.</au><au>Rayburn, William F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental transfer of milrinone in the nonhuman primate (baboon)</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>174</volume><issue>3</issue><spage>895</spage><epage>896</epage><pages>895-896</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Milrinone is an inotropic agent for short-term intravenous use in the management of congestive heart failure. The purpose of this article is to question the previously reported lack of transplacental transfer of milrinone. Loading and continuous intravenous doses, considered to be therapeutic in humans, were administered to four near-term baboons. Transplacental passage was documented, with a maternal/fetal serum ratio of approximately 4:1 found during the 3 hours of infusion. (A
M J O
BSTET G
YNECOL 1996;174:895-6.)</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>8633664</pmid><doi>10.1016/S0002-9378(96)70321-6</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1996-03, Vol.174 (3), p.895-896 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals baboon Biological and medical sciences Cardiotonic agents Cardiotonic Agents - administration & dosage Cardiotonic Agents - blood Cardiotonic Agents - pharmacology Cardiovascular system Female Fetal Blood - metabolism Infusions, Intravenous Medical sciences Milrinone Papio Pharmacology. Drug treatments Placenta Placenta - metabolism Pregnancy Pyridones - administration & dosage Pyridones - blood Pyridones - pharmacokinetics |
| title | Placental transfer of milrinone in the nonhuman primate (baboon) |
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