Demonstration of efficacy of combining corticosteroids and colchicine in two patients with idiopathic sclerosing mesenteritis
Sclerosing mesenteritis is an uncommon condition of unknown etiology. It is likely to be the fibrous evolution of mesenteric panniculitis. It often has an indolent course but may be complicated by progressive bowel obstruction. The treatment of the symptomatic forms is not well established. The obse...
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| Veröffentlicht in: | Digestive diseases and sciences 1996-04, Vol.41 (4), p.684-688 |
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| container_title | Digestive diseases and sciences |
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| creator | GENEREAU, T BELLIN, M.-F WECHSLER, B DU, L. T. H BELLANGER, J GRELLET, J GODEAU, P |
| description | Sclerosing mesenteritis is an uncommon condition of unknown etiology. It is likely to be the fibrous evolution of mesenteric panniculitis. It often has an indolent course but may be complicated by progressive bowel obstruction. The treatment of the symptomatic forms is not well established. The observations of two women (20 and 65 years old) with a relentless downhill course of biopsy-proved sclerosing mesenteritis are described. A treatment regimen with corticosteroid therapy (initially 1 mg/kg/day) and colchicine (1 mg/day) led, in both cases, to a rapid improvement. Abdominal computer tomography showed reduction in the tumor size. The combination of corticosteroids and colchicine is helpful in the management of symptomatic sclerosing mesenteritis. Follow-up with abdominal computed tomography is useful in evaluating the therapeutic impact. |
| doi_str_mv | 10.1007/BF02213123 |
| format | Article |
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Follow-up with abdominal computed tomography is useful in evaluating the therapeutic impact.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02213123</identifier><identifier>PMID: 8674388</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Colchicine - administration & dosage ; Colchicine - therapeutic use ; Digestive system ; Drug Therapy, Combination ; Female ; Humans ; Intestinal Obstruction - etiology ; Medical sciences ; Mesentery - pathology ; Methylprednisolone - administration & dosage ; Methylprednisolone - therapeutic use ; Panniculitis, Peritoneal - complications ; Panniculitis, Peritoneal - diagnosis ; Panniculitis, Peritoneal - drug therapy ; Pharmacology. 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T. H</creatorcontrib><creatorcontrib>BELLANGER, J</creatorcontrib><creatorcontrib>GRELLET, J</creatorcontrib><creatorcontrib>GODEAU, P</creatorcontrib><title>Demonstration of efficacy of combining corticosteroids and colchicine in two patients with idiopathic sclerosing mesenteritis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Sclerosing mesenteritis is an uncommon condition of unknown etiology. It is likely to be the fibrous evolution of mesenteric panniculitis. It often has an indolent course but may be complicated by progressive bowel obstruction. The treatment of the symptomatic forms is not well established. The observations of two women (20 and 65 years old) with a relentless downhill course of biopsy-proved sclerosing mesenteritis are described. A treatment regimen with corticosteroid therapy (initially 1 mg/kg/day) and colchicine (1 mg/day) led, in both cases, to a rapid improvement. Abdominal computer tomography showed reduction in the tumor size. The combination of corticosteroids and colchicine is helpful in the management of symptomatic sclerosing mesenteritis. Follow-up with abdominal computed tomography is useful in evaluating the therapeutic impact.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Colchicine - administration & dosage</subject><subject>Colchicine - therapeutic use</subject><subject>Digestive system</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Obstruction - etiology</subject><subject>Medical sciences</subject><subject>Mesentery - pathology</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Panniculitis, Peritoneal - complications</subject><subject>Panniculitis, Peritoneal - diagnosis</subject><subject>Panniculitis, Peritoneal - drug therapy</subject><subject>Pharmacology. 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| ispartof | Digestive diseases and sciences, 1996-04, Vol.41 (4), p.684-688 |
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| subjects | Adult Aged Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Colchicine - administration & dosage Colchicine - therapeutic use Digestive system Drug Therapy, Combination Female Humans Intestinal Obstruction - etiology Medical sciences Mesentery - pathology Methylprednisolone - administration & dosage Methylprednisolone - therapeutic use Panniculitis, Peritoneal - complications Panniculitis, Peritoneal - diagnosis Panniculitis, Peritoneal - drug therapy Pharmacology. Drug treatments Prednisone - administration & dosage Prednisone - therapeutic use Sclerosis Tomography, X-Ray Computed |
| title | Demonstration of efficacy of combining corticosteroids and colchicine in two patients with idiopathic sclerosing mesenteritis |
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