Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

Glutamate transport is critical for synaptic inactivation of glutamate and prevention of excitotoxicity. The following four glutamate transporters have been identified in human brain: EAAT1, EAAT2, EAAT3, and EAAT4. Deficient glutamate transport has been identified in the motor cortex and the spinal...

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Veröffentlicht in:	Annals of neurology 1996-05, Vol.39 (5), p.676-679
Hauptverfasser:	Bristol, Lynn A., Rothstein, Jeffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Amino Acid Transport System X-AG Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism ATP-Binding Cassette Transporters - genetics Autopsy Biological and medical sciences Biological Transport - genetics Blotting, Northern Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Excitatory Amino Acid Transporter 2 Female Gene Expression - physiology Humans Male Medical sciences Middle Aged Motor Cortex - chemistry Motor Cortex - physiology Neurology Receptors, Neurotransmitter - genetics RNA, Messenger - analysis
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