T lymphocytes from the normal human peritoneum contain high frequencies of Th2‐type CD8+ T cells
The majority of peritoneal T lymphocytes have been shown to be CD8+ and to co‐express CDw60. Expression of CDw60 characterizes CD8 T cells capable of secreting interleukin (IL)‐4 and supporting IgG production by B cells. We analyzed at the clonal level the functional cytokine profile of CD8+ T lymph...
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| Veröffentlicht in: | European journal of immunology 1996-04, Vol.26 (4), p.957-960 |
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| container_title | European journal of immunology |
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| creator | Birkhofer, Andreas Rehbock, Joachim Fricke, Harald |
| description | The majority of peritoneal T lymphocytes have been shown to be CD8+ and to co‐express CDw60. Expression of CDw60 characterizes CD8 T cells capable of secreting interleukin (IL)‐4 and supporting IgG production by B cells. We analyzed at the clonal level the functional cytokine profile of CD8+ T lymphocytes from the normal human peritoneum. While the majority of the clones produced interferon (IFN)‐γ and exhibited high alloantigen‐specific cytolytic activity, some clones secreted IL‐4 and IL‐5 but no detectable IFN‐γ. These Th2‐type CD8+ T cell clones provided substantial B cell help for IgG and IgA synthesis and exhibited reduced cytolytic activity. Our results suggest that distinct subsets of CD8+ T cell may occur in different immune compartments. |
| doi_str_mv | 10.1002/eji.1830260437 |
| format | Article |
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Expression of CDw60 characterizes CD8 T cells capable of secreting interleukin (IL)‐4 and supporting IgG production by B cells. We analyzed at the clonal level the functional cytokine profile of CD8+ T lymphocytes from the normal human peritoneum. While the majority of the clones produced interferon (IFN)‐γ and exhibited high alloantigen‐specific cytolytic activity, some clones secreted IL‐4 and IL‐5 but no detectable IFN‐γ. These Th2‐type CD8+ T cell clones provided substantial B cell help for IgG and IgA synthesis and exhibited reduced cytolytic activity. Our results suggest that distinct subsets of CD8+ T cell may occur in different immune compartments.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830260437</identifier><identifier>PMID: 8625996</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>AIDS/HIV ; Antigens, CD - analysis ; Antigens, Differentiation, T-Lymphocyte - analysis ; B-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes ; Cell Separation ; Cytotoxicity, Immunologic ; Female ; Gene Expression ; Human ; Humans ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - biosynthesis ; Interferon-gamma - secretion ; Interleukin-4 - secretion ; Interleukin-5 - secretion ; Lymphocyte Cooperation ; Lymphocyte Count ; Peritoneum ; Peritoneum - cytology ; Peritoneum - immunology ; RNA, Messenger - analysis ; T cell ; Th2 ; Th2 Cells</subject><ispartof>European journal of immunology, 1996-04, Vol.26 (4), p.957-960</ispartof><rights>Copyright © 1996 WILEY‐VCH Verlag GmbH & Co. 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Expression of CDw60 characterizes CD8 T cells capable of secreting interleukin (IL)‐4 and supporting IgG production by B cells. We analyzed at the clonal level the functional cytokine profile of CD8+ T lymphocytes from the normal human peritoneum. While the majority of the clones produced interferon (IFN)‐γ and exhibited high alloantigen‐specific cytolytic activity, some clones secreted IL‐4 and IL‐5 but no detectable IFN‐γ. These Th2‐type CD8+ T cell clones provided substantial B cell help for IgG and IgA synthesis and exhibited reduced cytolytic activity. Our results suggest that distinct subsets of CD8+ T cell may occur in different immune compartments.</description><subject>AIDS/HIV</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, Differentiation, T-Lymphocyte - analysis</subject><subject>B-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Cell Separation</subject><subject>Cytotoxicity, Immunologic</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Human</subject><subject>Humans</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Interferon-gamma - secretion</subject><subject>Interleukin-4 - secretion</subject><subject>Interleukin-5 - secretion</subject><subject>Lymphocyte Cooperation</subject><subject>Lymphocyte Count</subject><subject>Peritoneum</subject><subject>Peritoneum - cytology</subject><subject>Peritoneum - immunology</subject><subject>RNA, Messenger - analysis</subject><subject>T cell</subject><subject>Th2</subject><subject>Th2 Cells</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1OwzAUhS0EKuVnZUPyxIJSbMd24hGVAkWVWMocOck1SZXEwU6EsvEIPCNPQqpWwMZ0h_OdT1cHoQtKZpQQdgObckbjkDBJeBgdoCkVjAaccnqIpoRQHjAVk2N04v2GEKKkUBM0iSUTSskpSte4Guq2sNnQgcfG2Rp3BeDGulpXuOhr3eAWXNnZBvoaZ7bpdNngonwtRhreemiycmxag9cF-_r47IYW8PwuvsZrnEFV-TN0ZHTl4Xx_T9HL_WI9fwxWzw_L-e0qyEJOosCISJs8YwTyzEgNXLBcUROC4kLoVOZc5kymVIdKgOAmpYzzSIyIAcalCU_R1c7bOju-5bukLv32A92A7X0SxYREkosRnO3AzFnvHZikdWWt3ZBQkmxHTcZRk99Rx8Ll3tynNeQ_-H7FMVe7_L2sYPjHliyeln_c3_xJhGU</recordid><startdate>199604</startdate><enddate>199604</enddate><creator>Birkhofer, Andreas</creator><creator>Rehbock, Joachim</creator><creator>Fricke, Harald</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199604</creationdate><title>T lymphocytes from the normal human peritoneum contain high frequencies of Th2‐type CD8+ T cells</title><author>Birkhofer, Andreas ; Rehbock, Joachim ; Fricke, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3407-f57afdc20edcf6ae452d91f3e9455ab6d46d26b1a395e54fb12447591ffe246f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS/HIV</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, Differentiation, T-Lymphocyte - analysis</topic><topic>B-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Cell Separation</topic><topic>Cytotoxicity, Immunologic</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Human</topic><topic>Humans</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Interferon-gamma - secretion</topic><topic>Interleukin-4 - secretion</topic><topic>Interleukin-5 - secretion</topic><topic>Lymphocyte Cooperation</topic><topic>Lymphocyte Count</topic><topic>Peritoneum</topic><topic>Peritoneum - cytology</topic><topic>Peritoneum - immunology</topic><topic>RNA, Messenger - analysis</topic><topic>T cell</topic><topic>Th2</topic><topic>Th2 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Birkhofer, Andreas</creatorcontrib><creatorcontrib>Rehbock, Joachim</creatorcontrib><creatorcontrib>Fricke, Harald</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Birkhofer, Andreas</au><au>Rehbock, Joachim</au><au>Fricke, Harald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T lymphocytes from the normal human peritoneum contain high frequencies of Th2‐type CD8+ T cells</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1996-04</date><risdate>1996</risdate><volume>26</volume><issue>4</issue><spage>957</spage><epage>960</epage><pages>957-960</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>The majority of peritoneal T lymphocytes have been shown to be CD8+ and to co‐express CDw60. Expression of CDw60 characterizes CD8 T cells capable of secreting interleukin (IL)‐4 and supporting IgG production by B cells. We analyzed at the clonal level the functional cytokine profile of CD8+ T lymphocytes from the normal human peritoneum. While the majority of the clones produced interferon (IFN)‐γ and exhibited high alloantigen‐specific cytolytic activity, some clones secreted IL‐4 and IL‐5 but no detectable IFN‐γ. These Th2‐type CD8+ T cell clones provided substantial B cell help for IgG and IgA synthesis and exhibited reduced cytolytic activity. Our results suggest that distinct subsets of CD8+ T cell may occur in different immune compartments.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>8625996</pmid><doi>10.1002/eji.1830260437</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1996-04, Vol.26 (4), p.957-960 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78007645 |
| source | MEDLINE; Wiley Journals |
| subjects | AIDS/HIV Antigens, CD - analysis Antigens, Differentiation, T-Lymphocyte - analysis B-Lymphocytes - immunology CD8-Positive T-Lymphocytes Cell Separation Cytotoxicity, Immunologic Female Gene Expression Human Humans Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Interferon-gamma - secretion Interleukin-4 - secretion Interleukin-5 - secretion Lymphocyte Cooperation Lymphocyte Count Peritoneum Peritoneum - cytology Peritoneum - immunology RNA, Messenger - analysis T cell Th2 Th2 Cells |
| title | T lymphocytes from the normal human peritoneum contain high frequencies of Th2‐type CD8+ T cells |
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