Comparative Molecular Field Analysis-Based Prediction of Drug Affinities at Recombinant D1A Dopamine Receptors

Determination of quantitative structure−activity relationships (QSAR) for affinity at particular dopamine (DA) receptors has become an even greater priority with the cloning of five DA receptor subtypes. The use of agonist affinity at recombinant receptors selectively expressed in clonal cells as th...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-02, Vol.39 (4), p.850-859
Hauptverfasser:	Brusniak, Mi-Youn Kim, Pearlman, Robert S, Neve, Kim A, Wilcox, Richard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cercopithecus aethiops Computer Graphics Dopamine - analogs & derivatives Dopamine - chemistry Dopamine - metabolism Dopamine Agonists - chemistry Dopamine Agonists - metabolism Glioma Humans Kinetics Models, Molecular Receptors, Dopamine D1 - metabolism Recombinant Proteins - metabolism Structure-Activity Relationship Tumor Cells, Cultured
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