Pneumocystis carinii Infection in Transgenic B Cell-Deficient Mice
Pneumocystis carinii is an important cause of pneumonia in immunocompromised hosts. Both cellular and humoral immunity seem important in resistance to this pathogen, but the specific role of each component is poorly understood. An outbreak of P. carinii pneumonia in transgenic B cell-deficient mice...
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| Veröffentlicht in: | The Journal of infectious diseases 1996-04, Vol.173 (4), p.1034-1037 |
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| container_title | The Journal of infectious diseases |
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| creator | Marcotte, Harold Lévesque, Denise Delanay, Kathleen Bourgeault, Andrée de la Durantaye, Roger Brochu, Steve Lavoie, Marc C. |
| description | Pneumocystis carinii is an important cause of pneumonia in immunocompromised hosts. Both cellular and humoral immunity seem important in resistance to this pathogen, but the specific role of each component is poorly understood. An outbreak of P. carinii pneumonia in transgenic B cell-deficient mice (µMT) was studied. Over 4 months, >50% of 41 µMT/µMT mice maintained in a sterile environment died of pneumonia. Some mice had concurrent infection with Pasteurella pneumotropica. Homozygous µMT/µMT mice had no detectable serum immunoglobulins, while their heterozygous µMT/+ counterparts had normal levels of IgM, IgG, and IgA and did not develop pneumonia. The infection was controlled by treating the mice with trimethoprim-sulfamethoxazole, and the pathogen was eliminated by cesarean rederivation. These observations suggest an important role for B cells in the host defense against P. carinii. |
| doi_str_mv | 10.1093/infdis/173.4.1034 |
| format | Article |
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Both cellular and humoral immunity seem important in resistance to this pathogen, but the specific role of each component is poorly understood. An outbreak of P. carinii pneumonia in transgenic B cell-deficient mice (µMT) was studied. Over 4 months, >50% of 41 µMT/µMT mice maintained in a sterile environment died of pneumonia. Some mice had concurrent infection with Pasteurella pneumotropica. Homozygous µMT/µMT mice had no detectable serum immunoglobulins, while their heterozygous µMT/+ counterparts had normal levels of IgM, IgG, and IgA and did not develop pneumonia. The infection was controlled by treating the mice with trimethoprim-sulfamethoxazole, and the pathogen was eliminated by cesarean rederivation. These observations suggest an important role for B cells in the host defense against P. carinii.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/173.4.1034</identifier><identifier>PMID: 8603947</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Amibiasis ; Animals ; Animals, Laboratory - microbiology ; B lymphocytes ; B-Lymphocytes - immunology ; Biological and medical sciences ; Concise Communications ; Dysgammaglobulinemia - genetics ; Dysgammaglobulinemia - immunology ; Dysgammaglobulinemia - microbiology ; Genes, Immunoglobulin ; Human mycoses ; Human protozoal diseases ; Immunoglobulin mu-Chains - genetics ; Immunoglobulins ; Infections ; Infectious diseases ; Lung - microbiology ; Medical sciences ; Mice ; Mice, Knockout ; Miscellaneous ; Mycoses ; Mycoses of the respiratory system ; Parasitic diseases ; Pathogens ; Pneumocystis - immunology ; Pneumocystis carinii ; Pneumocystis pneumonia ; Pneumonia ; Pneumonia, Pneumocystis - immunology ; Pneumonia, Pneumocystis - veterinary ; Protozoal diseases ; Pulmonary alveoli ; T lymphocytes ; Viruses</subject><ispartof>The Journal of infectious diseases, 1996-04, Vol.173 (4), p.1034-1037</ispartof><rights>Copyright 1996 The University of Chicago</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-4452184e0a20ce8ac306403b5d10cbc596b2c1172f675a58fca54301ebbbe06b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30132617$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30132617$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3034695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8603947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marcotte, Harold</creatorcontrib><creatorcontrib>Lévesque, Denise</creatorcontrib><creatorcontrib>Delanay, Kathleen</creatorcontrib><creatorcontrib>Bourgeault, Andrée</creatorcontrib><creatorcontrib>de la Durantaye, Roger</creatorcontrib><creatorcontrib>Brochu, Steve</creatorcontrib><creatorcontrib>Lavoie, Marc C.</creatorcontrib><title>Pneumocystis carinii Infection in Transgenic B Cell-Deficient Mice</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Pneumocystis carinii is an important cause of pneumonia in immunocompromised hosts. Both cellular and humoral immunity seem important in resistance to this pathogen, but the specific role of each component is poorly understood. An outbreak of P. carinii pneumonia in transgenic B cell-deficient mice (µMT) was studied. Over 4 months, >50% of 41 µMT/µMT mice maintained in a sterile environment died of pneumonia. Some mice had concurrent infection with Pasteurella pneumotropica. Homozygous µMT/µMT mice had no detectable serum immunoglobulins, while their heterozygous µMT/+ counterparts had normal levels of IgM, IgG, and IgA and did not develop pneumonia. The infection was controlled by treating the mice with trimethoprim-sulfamethoxazole, and the pathogen was eliminated by cesarean rederivation. These observations suggest an important role for B cells in the host defense against P. carinii.</description><subject>Amibiasis</subject><subject>Animals</subject><subject>Animals, Laboratory - microbiology</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Concise Communications</subject><subject>Dysgammaglobulinemia - genetics</subject><subject>Dysgammaglobulinemia - immunology</subject><subject>Dysgammaglobulinemia - microbiology</subject><subject>Genes, Immunoglobulin</subject><subject>Human mycoses</subject><subject>Human protozoal diseases</subject><subject>Immunoglobulin mu-Chains - genetics</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Lung - microbiology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Miscellaneous</subject><subject>Mycoses</subject><subject>Mycoses of the respiratory system</subject><subject>Parasitic diseases</subject><subject>Pathogens</subject><subject>Pneumocystis - immunology</subject><subject>Pneumocystis carinii</subject><subject>Pneumocystis pneumonia</subject><subject>Pneumonia</subject><subject>Pneumonia, Pneumocystis - immunology</subject><subject>Pneumonia, Pneumocystis - veterinary</subject><subject>Protozoal diseases</subject><subject>Pulmonary alveoli</subject><subject>T lymphocytes</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2qFQ20P4BDpT1U3BZm_Ll7LKF8SKTtgUpRL5Z34kWmiRfsjVT-PY4SPm49jeT3nUfjh7FDhGOEVpyE2C9CPkEjjmV5EfIdm6ASptYaxXs2AeC8xqZtP7L9nO8AQApt9theo0G00kzY6a_o16uBHvMYckUuhRhCdRV7T2MYYhVidZNczLc-BqpOq6lfLusz3wcKPo7VLJD_xD70bpn95908YL_Pv99ML-vrnxdX02_XNSmuxlpKxbGRHhwH8o0jAVqC6NQCgTpSre44IRrea6OcanpySgpA33WdB92JA3a05d6n4WHt82hXIVO5x0U_rLM1Tfmels1_i6g0GNXyUsRtkdKQc_K9vU9h5dKjRbAbwXYr2BbBVtqN4LLzZQdfdyu_eNnYGS35113uMrllX-RRITzXRGHoVr1i7vI4pDcxCq5xg6m3ecij__eSu_TXaiOMspfzPxYvcDab_5hbJZ4AEYicGg</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Marcotte, Harold</creator><creator>Lévesque, Denise</creator><creator>Delanay, Kathleen</creator><creator>Bourgeault, Andrée</creator><creator>de la Durantaye, Roger</creator><creator>Brochu, Steve</creator><creator>Lavoie, Marc C.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Pneumocystis carinii Infection in Transgenic B Cell-Deficient Mice</title><author>Marcotte, Harold ; Lévesque, Denise ; Delanay, Kathleen ; Bourgeault, Andrée ; de la Durantaye, Roger ; Brochu, Steve ; Lavoie, Marc C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-4452184e0a20ce8ac306403b5d10cbc596b2c1172f675a58fca54301ebbbe06b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amibiasis</topic><topic>Animals</topic><topic>Animals, Laboratory - microbiology</topic><topic>B lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Concise Communications</topic><topic>Dysgammaglobulinemia - genetics</topic><topic>Dysgammaglobulinemia - immunology</topic><topic>Dysgammaglobulinemia - microbiology</topic><topic>Genes, Immunoglobulin</topic><topic>Human mycoses</topic><topic>Human protozoal diseases</topic><topic>Immunoglobulin mu-Chains - genetics</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Lung - microbiology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Miscellaneous</topic><topic>Mycoses</topic><topic>Mycoses of the respiratory system</topic><topic>Parasitic diseases</topic><topic>Pathogens</topic><topic>Pneumocystis - immunology</topic><topic>Pneumocystis carinii</topic><topic>Pneumocystis pneumonia</topic><topic>Pneumonia</topic><topic>Pneumonia, Pneumocystis - immunology</topic><topic>Pneumonia, Pneumocystis - veterinary</topic><topic>Protozoal diseases</topic><topic>Pulmonary alveoli</topic><topic>T lymphocytes</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marcotte, Harold</creatorcontrib><creatorcontrib>Lévesque, Denise</creatorcontrib><creatorcontrib>Delanay, Kathleen</creatorcontrib><creatorcontrib>Bourgeault, Andrée</creatorcontrib><creatorcontrib>de la Durantaye, Roger</creatorcontrib><creatorcontrib>Brochu, Steve</creatorcontrib><creatorcontrib>Lavoie, Marc C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marcotte, Harold</au><au>Lévesque, Denise</au><au>Delanay, Kathleen</au><au>Bourgeault, Andrée</au><au>de la Durantaye, Roger</au><au>Brochu, Steve</au><au>Lavoie, Marc C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pneumocystis carinii Infection in Transgenic B Cell-Deficient Mice</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>173</volume><issue>4</issue><spage>1034</spage><epage>1037</epage><pages>1034-1037</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Pneumocystis carinii is an important cause of pneumonia in immunocompromised hosts. 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These observations suggest an important role for B cells in the host defense against P. carinii.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8603947</pmid><doi>10.1093/infdis/173.4.1034</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1996-04, Vol.173 (4), p.1034-1037 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Amibiasis Animals Animals, Laboratory - microbiology B lymphocytes B-Lymphocytes - immunology Biological and medical sciences Concise Communications Dysgammaglobulinemia - genetics Dysgammaglobulinemia - immunology Dysgammaglobulinemia - microbiology Genes, Immunoglobulin Human mycoses Human protozoal diseases Immunoglobulin mu-Chains - genetics Immunoglobulins Infections Infectious diseases Lung - microbiology Medical sciences Mice Mice, Knockout Miscellaneous Mycoses Mycoses of the respiratory system Parasitic diseases Pathogens Pneumocystis - immunology Pneumocystis carinii Pneumocystis pneumonia Pneumonia Pneumonia, Pneumocystis - immunology Pneumonia, Pneumocystis - veterinary Protozoal diseases Pulmonary alveoli T lymphocytes Viruses |
| title | Pneumocystis carinii Infection in Transgenic B Cell-Deficient Mice |
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