Investigations of Breast Tumors with Fluorine-18-Fluorodeoxyglucose and SPECT
We designed a prospective study to investigate the feasibility of combined FDG-SPECT and whole-body acquisition in the diagnostic work-up of breast tumors applying visual analysis. We studied 50 patients with breast tumors of unknown histology. All malignant diseases were accurately detected in tumo...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1996-04, Vol.37 (4), p.615-622 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Holle, Lutz-H Trampert, Ludwin Lung-Kurt, Sabine Villena-Heinsen, Carlos E Puschel, Werner Schmidt, Sylvia Oberhausen, Erich |
| description | We designed a prospective study to investigate the feasibility of combined FDG-SPECT and whole-body acquisition in the diagnostic work-up of breast tumors applying visual analysis. We studied 50 patients with breast tumors of unknown histology.
All malignant diseases were accurately detected in tumors > 2.3 cm, while the smallest FDG-positive lesion was 1.4 cm. In a subgroup of these patients, quantitative evaluation (tumor-to-back-group ratios) was added, which improved the sensitivity. Lymph node metastases were accurately indicated in 9 of 13 patients, while the detection of distant metastases depended on the location and size. False-positive FDG scans were observed in inflamed tissue, in a rapidly growing phylloides tumor and in supposedly healthy breasts.
These results are comparable with prior investigations of other groups using PET. Therefore, FDG-SPECT and whole-body acquisition may be an adequate and less expensive technique to meet the increasing demand of FDG examinations. |
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All malignant diseases were accurately detected in tumors > 2.3 cm, while the smallest FDG-positive lesion was 1.4 cm. In a subgroup of these patients, quantitative evaluation (tumor-to-back-group ratios) was added, which improved the sensitivity. Lymph node metastases were accurately indicated in 9 of 13 patients, while the detection of distant metastases depended on the location and size. False-positive FDG scans were observed in inflamed tissue, in a rapidly growing phylloides tumor and in supposedly healthy breasts.
These results are comparable with prior investigations of other groups using PET. Therefore, FDG-SPECT and whole-body acquisition may be an adequate and less expensive technique to meet the increasing demand of FDG examinations.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 8691251</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Biological and medical sciences ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Deoxyglucose - analogs & derivatives ; Endocrine glands. Genital system. Mammary gland ; Feasibility Studies ; Female ; Fluorine Radioisotopes ; Fluorodeoxyglucose F18 ; Gamma Cameras ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lymphatic Metastasis ; Medical sciences ; Middle Aged ; Neoplasm Metastasis ; Prospective Studies ; Radionuclide investigations ; Sensitivity and Specificity ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>The Journal of nuclear medicine (1978), 1996-04, Vol.37 (4), p.615-622</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright Society of Nuclear Medicine Apr 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3107755$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8691251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holle, Lutz-H</creatorcontrib><creatorcontrib>Trampert, Ludwin</creatorcontrib><creatorcontrib>Lung-Kurt, Sabine</creatorcontrib><creatorcontrib>Villena-Heinsen, Carlos E</creatorcontrib><creatorcontrib>Puschel, Werner</creatorcontrib><creatorcontrib>Schmidt, Sylvia</creatorcontrib><creatorcontrib>Oberhausen, Erich</creatorcontrib><title>Investigations of Breast Tumors with Fluorine-18-Fluorodeoxyglucose and SPECT</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>We designed a prospective study to investigate the feasibility of combined FDG-SPECT and whole-body acquisition in the diagnostic work-up of breast tumors applying visual analysis. We studied 50 patients with breast tumors of unknown histology.
All malignant diseases were accurately detected in tumors > 2.3 cm, while the smallest FDG-positive lesion was 1.4 cm. In a subgroup of these patients, quantitative evaluation (tumor-to-back-group ratios) was added, which improved the sensitivity. Lymph node metastases were accurately indicated in 9 of 13 patients, while the detection of distant metastases depended on the location and size. False-positive FDG scans were observed in inflamed tissue, in a rapidly growing phylloides tumor and in supposedly healthy breasts.
These results are comparable with prior investigations of other groups using PET. Therefore, FDG-SPECT and whole-body acquisition may be an adequate and less expensive technique to meet the increasing demand of FDG examinations.</description><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Endocrine glands. Genital system. Mammary gland</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fluorine Radioisotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gamma Cameras</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Prospective Studies</subject><subject>Radionuclide investigations</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkdFKwzAUhosoc04fQSgi3hWSNGnTSx2bDiYKzuuQpidrRpvMpHXu7a06FLw6B_6Pn49zjqIxZilLWJblx9EY4QwnjCF2Gp2FsEEIZZzzUTTiWYEJw-PocWHfIXRmLTvjbIidju88yNDFq751PsQ709XxvOmdNxYSzJPv3VXgPvbrplcuQCxtFb88z6ar8-hEyybAxWFOotf5bDV9SJZP94vp7TKpSZF2iSpxRSnXSnKQXMqixDoHrVShi5RDVZFKU5JXnLCSY9BAqVIlo1yiDBcM0kl089O79e6tH_xFa4KCppEWXB9EzhFKKcEDePUP3Lje28FNEFyQdLAgA3R5gPqyhUpsvWml34vDkYb8-pDLoGSjvbTKhF8sxSjPGfuTqs263hkPwvaqAem_Oje2TXNBRTa85xP9L35u</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Holle, Lutz-H</creator><creator>Trampert, Ludwin</creator><creator>Lung-Kurt, Sabine</creator><creator>Villena-Heinsen, Carlos E</creator><creator>Puschel, Werner</creator><creator>Schmidt, Sylvia</creator><creator>Oberhausen, Erich</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Investigations of Breast Tumors with Fluorine-18-Fluorodeoxyglucose and SPECT</title><author>Holle, Lutz-H ; Trampert, Ludwin ; Lung-Kurt, Sabine ; Villena-Heinsen, Carlos E ; Puschel, Werner ; Schmidt, Sylvia ; Oberhausen, Erich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h293t-cb1d448fca8ea8aa9b1f7efcc9f938edd2df427d825b81efe44ccb548a06195e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Deoxyglucose - analogs & derivatives</topic><topic>Endocrine glands. Genital system. Mammary gland</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fluorine Radioisotopes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gamma Cameras</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Prospective Studies</topic><topic>Radionuclide investigations</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holle, Lutz-H</creatorcontrib><creatorcontrib>Trampert, Ludwin</creatorcontrib><creatorcontrib>Lung-Kurt, Sabine</creatorcontrib><creatorcontrib>Villena-Heinsen, Carlos E</creatorcontrib><creatorcontrib>Puschel, Werner</creatorcontrib><creatorcontrib>Schmidt, Sylvia</creatorcontrib><creatorcontrib>Oberhausen, Erich</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holle, Lutz-H</au><au>Trampert, Ludwin</au><au>Lung-Kurt, Sabine</au><au>Villena-Heinsen, Carlos E</au><au>Puschel, Werner</au><au>Schmidt, Sylvia</au><au>Oberhausen, Erich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigations of Breast Tumors with Fluorine-18-Fluorodeoxyglucose and SPECT</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>37</volume><issue>4</issue><spage>615</spage><epage>622</epage><pages>615-622</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>We designed a prospective study to investigate the feasibility of combined FDG-SPECT and whole-body acquisition in the diagnostic work-up of breast tumors applying visual analysis. We studied 50 patients with breast tumors of unknown histology.
All malignant diseases were accurately detected in tumors > 2.3 cm, while the smallest FDG-positive lesion was 1.4 cm. In a subgroup of these patients, quantitative evaluation (tumor-to-back-group ratios) was added, which improved the sensitivity. Lymph node metastases were accurately indicated in 9 of 13 patients, while the detection of distant metastases depended on the location and size. False-positive FDG scans were observed in inflamed tissue, in a rapidly growing phylloides tumor and in supposedly healthy breasts.
These results are comparable with prior investigations of other groups using PET. Therefore, FDG-SPECT and whole-body acquisition may be an adequate and less expensive technique to meet the increasing demand of FDG examinations.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>8691251</pmid><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1996-04, Vol.37 (4), p.615-622 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Deoxyglucose - analogs & derivatives Endocrine glands. Genital system. Mammary gland Feasibility Studies Female Fluorine Radioisotopes Fluorodeoxyglucose F18 Gamma Cameras Humans Investigative techniques, diagnostic techniques (general aspects) Lymphatic Metastasis Medical sciences Middle Aged Neoplasm Metastasis Prospective Studies Radionuclide investigations Sensitivity and Specificity Tomography, Emission-Computed, Single-Photon |
| title | Investigations of Breast Tumors with Fluorine-18-Fluorodeoxyglucose and SPECT |
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