The flavohaemoglobin (HMP) of Escherichia coli generates superoxide in vitro and causes oxidative stress in vivo

Purified flavohaemoglobin (HMP) of Escherichia coli reduces Fe(III) in a superoxide dismuatase (SOD)-sensitive reaction, demonstrating superoxide anion generation during aerobic NADH oxidation. In vivo, sodA-lacZ fusion activity was increased 3-fold by introducing plasmid pPL341, containing the hmp...

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Veröffentlicht in:	FEBS letters 1996-03, Vol.382 (1), p.141-144
Hauptverfasser:	Membrillo-Hernández, Jorge, Ioannidis, Nicolaos, Poole, Robert K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobiosis Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - physiology beta-Galactosidase - biosynthesis beta-Galactosidase - genetics Dihydropteridine Reductase Enzyme Induction Escherichia coli Escherichia coli - metabolism Escherichia coli Proteins Ferric Compounds - metabolism Flavohaemoglobin Hemeproteins - genetics Hemeproteins - metabolism Hemoglobin Integration host factor Integration Host Factors NADH, NADPH Oxidoreductases Oxidation-Reduction Oxidative Stress - physiology Paraquat - pharmacology Recombinant Fusion Proteins - biosynthesis Superoxide dismutase Superoxide Dismutase - biosynthesis Superoxide Dismutase - genetics Superoxides - metabolism Suporoxide Trans-Activators Transcription Transcription Factors - genetics Transcription Factors - physiology
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