BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines
Malignant gliomas aggressively invade the surrounding normal brain, whereas brain metastases of nonglial tumors do not. The invasive behavior of gliomas may be mediated by tissue- or tumor-specific extracellular proteins. mRNA for the brain-specific extracellular brain enriched hyaluronan-binding pr...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1996-05, Vol.56 (10), p.2293-2298 |
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| creator | JAWORSKI, D. M KELLY, G. M PIEPMEIER, J. M HOCKFIELD, S |
| description | Malignant gliomas aggressively invade the surrounding normal brain, whereas brain metastases of nonglial tumors do not. The invasive behavior of gliomas may be mediated by tissue- or tumor-specific extracellular proteins. mRNA for the brain-specific extracellular brain enriched hyaluronan-binding protein (BEHAB) is not detectable in normal adult human cortex or in any nonglioma tumor examined. BEHAB is consistently expressed in surgical samples of glioma (n = 27). Glioma cell lines maintained under standard cell culture conditions or grown as s.c. tumors do not express BEHAB. When grown as intracranial grafts, glioma cell lines that invade the brain express BEHAB, whereas noninvasive cell lines do not. BEHAB is a unique and selective marker for glioma and may play a role in tumor invasion. |
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M ; KELLY, G. M ; PIEPMEIER, J. M ; HOCKFIELD, S</creator><creatorcontrib>JAWORSKI, D. M ; KELLY, G. M ; PIEPMEIER, J. M ; HOCKFIELD, S</creatorcontrib><description>Malignant gliomas aggressively invade the surrounding normal brain, whereas brain metastases of nonglial tumors do not. The invasive behavior of gliomas may be mediated by tissue- or tumor-specific extracellular proteins. mRNA for the brain-specific extracellular brain enriched hyaluronan-binding protein (BEHAB) is not detectable in normal adult human cortex or in any nonglioma tumor examined. BEHAB is consistently expressed in surgical samples of glioma (n = 27). Glioma cell lines maintained under standard cell culture conditions or grown as s.c. tumors do not express BEHAB. When grown as intracranial grafts, glioma cell lines that invade the brain express BEHAB, whereas noninvasive cell lines do not. BEHAB is a unique and selective marker for glioma and may play a role in tumor invasion.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 8625302</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adolescent ; Adult ; Animals ; Biological and medical sciences ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Brevican ; Carrier Proteins - biosynthesis ; Carrier Proteins - genetics ; Child, Preschool ; Chondroitin Sulfate Proteoglycans ; Female ; Glioma - genetics ; Glioma - metabolism ; Glioma - pathology ; Humans ; Hyaluronic Acid - metabolism ; In Situ Hybridization ; Lectins, C-Type ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness - genetics ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - genetics ; Neoplasm Transplantation ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Neurology ; Rats ; Rats, Inbred Lew ; Rats, Sprague-Dawley ; Tumor Cells, Cultured ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Cancer research (Chicago, Ill.), 1996-05, Vol.56 (10), p.2293-2298</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3081193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8625302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JAWORSKI, D. M</creatorcontrib><creatorcontrib>KELLY, G. M</creatorcontrib><creatorcontrib>PIEPMEIER, J. M</creatorcontrib><creatorcontrib>HOCKFIELD, S</creatorcontrib><title>BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Malignant gliomas aggressively invade the surrounding normal brain, whereas brain metastases of nonglial tumors do not. The invasive behavior of gliomas may be mediated by tissue- or tumor-specific extracellular proteins. mRNA for the brain-specific extracellular brain enriched hyaluronan-binding protein (BEHAB) is not detectable in normal adult human cortex or in any nonglioma tumor examined. BEHAB is consistently expressed in surgical samples of glioma (n = 27). Glioma cell lines maintained under standard cell culture conditions or grown as s.c. tumors do not express BEHAB. When grown as intracranial grafts, glioma cell lines that invade the brain express BEHAB, whereas noninvasive cell lines do not. BEHAB is a unique and selective marker for glioma and may play a role in tumor invasion.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Brevican</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Carrier Proteins - genetics</subject><subject>Child, Preschool</subject><subject>Chondroitin Sulfate Proteoglycans</subject><subject>Female</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Hyaluronic Acid - metabolism</subject><subject>In Situ Hybridization</subject><subject>Lectins, C-Type</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Transplantation</subject><subject>Nerve Tissue Proteins - biosynthesis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Rats, Sprague-Dawley</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90F9LwzAQAPAgypzTjyDkQUQfCmnTrOnjNuYfGPiy93JNL12kTWuyDvch_M7GWX04juN-HHd3Rqax4DLK0lSckyljTEYizZJLcuX9eyhFzMSETOQ8EZwlU_K1XL8slvShdGAsReuM2mFFd0doBtdZsLQ0tjK2fqTGU_zsHXofQMB-cLVR0FAPbd-gp52mdWO6FijYkzB270A5sCao2oHen5CxB_DmgH9aYdPQxlj01-RCQ-PxZswzsn1ab1cv0ebt-XW12ES7ZJ7vI1RlmSciU6hFCC1zyXWlSw6Y6kyWsVaq0vOES8XzCjCpuOYsR4Ec4zzlM3L_O7Z33ceAfl-0xv9sARa7wReZZCzOMhng7QiHssWq6J1pwR2L8X2hfzf2wYdP6HCqMv6fcSbjOOf8G4kqfOY</recordid><startdate>19960515</startdate><enddate>19960515</enddate><creator>JAWORSKI, D. M</creator><creator>KELLY, G. M</creator><creator>PIEPMEIER, J. M</creator><creator>HOCKFIELD, S</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19960515</creationdate><title>BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines</title><author>JAWORSKI, D. M ; KELLY, G. M ; PIEPMEIER, J. M ; HOCKFIELD, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-ecbb9257cef5ceff8983fdfb3ae4f78b1fccdf6238c39dae2d3f309e5e3e1943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Brevican</topic><topic>Carrier Proteins - biosynthesis</topic><topic>Carrier Proteins - genetics</topic><topic>Child, Preschool</topic><topic>Chondroitin Sulfate Proteoglycans</topic><topic>Female</topic><topic>Glioma - genetics</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Hyaluronic Acid - metabolism</topic><topic>In Situ Hybridization</topic><topic>Lectins, C-Type</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Transplantation</topic><topic>Nerve Tissue Proteins - biosynthesis</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Rats, Sprague-Dawley</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JAWORSKI, D. M</creatorcontrib><creatorcontrib>KELLY, G. M</creatorcontrib><creatorcontrib>PIEPMEIER, J. M</creatorcontrib><creatorcontrib>HOCKFIELD, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JAWORSKI, D. M</au><au>KELLY, G. M</au><au>PIEPMEIER, J. M</au><au>HOCKFIELD, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1996-05-15</date><risdate>1996</risdate><volume>56</volume><issue>10</issue><spage>2293</spage><epage>2298</epage><pages>2293-2298</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Malignant gliomas aggressively invade the surrounding normal brain, whereas brain metastases of nonglial tumors do not. The invasive behavior of gliomas may be mediated by tissue- or tumor-specific extracellular proteins. mRNA for the brain-specific extracellular brain enriched hyaluronan-binding protein (BEHAB) is not detectable in normal adult human cortex or in any nonglioma tumor examined. BEHAB is consistently expressed in surgical samples of glioma (n = 27). Glioma cell lines maintained under standard cell culture conditions or grown as s.c. tumors do not express BEHAB. When grown as intracranial grafts, glioma cell lines that invade the brain express BEHAB, whereas noninvasive cell lines do not. BEHAB is a unique and selective marker for glioma and may play a role in tumor invasion.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8625302</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Animals Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brevican Carrier Proteins - biosynthesis Carrier Proteins - genetics Child, Preschool Chondroitin Sulfate Proteoglycans Female Glioma - genetics Glioma - metabolism Glioma - pathology Humans Hyaluronic Acid - metabolism In Situ Hybridization Lectins, C-Type Male Medical sciences Middle Aged Neoplasm Invasiveness - genetics Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Transplantation Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurology Rats Rats, Inbred Lew Rats, Sprague-Dawley Tumor Cells, Cultured Tumors of the nervous system. Phacomatoses |
| title | BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines |
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