Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix
To explore the possibility of using histologic microvessel count of sections from the tumor to predict recurrence of stage Ib squamous cell carcinoma of the cervix. Tumor sections from 22 patients (11 patients free of disease after 3 years and 11 patients with recurrence) were stained histoimmunoche...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1996-05, Vol.87 (5), p.751-754 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Dinh, Tung V. Hannigan, Edward V. Smith, Edward R. Hove, Maxwell J. Chopra, Vimlarani To, Tonia |
| description | To explore the possibility of using histologic microvessel count of sections from the tumor to predict recurrence of stage Ib squamous cell carcinoma of the cervix.
Tumor sections from 22 patients (11 patients free of disease after 3 years and 11 patients with recurrence) were stained histoimmunochemically for factor VIII-related antigens. Vessel counting in the most active area of angiogenesis was performed by two pathologists on a x 200 microscopic field (0.739 mm2) without knowledge of the patients' outcome. To predict recurrence, vessel count was compared with age, tumor size, tumor grade, lymph-vascular invasion, duration of follow-up, and type of therapy.
Only high microvessel count (mean 19.9, range 7–43, versus mean 30.1, range 17–78; P < .05) and tumor size (mean 2.84 cm, range 1–4.2, versus mean 4.11 cm, range 2.2–6; P < .05) were independent factors predicting recurrence.
High microvessel count in tumors may be used to predict recurrence in stage Ib squamous cell carcinoma of the cervix. |
| doi_str_mv | 10.1016/0029-7844(96)00039-7 |
| format | Article |
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Tumor sections from 22 patients (11 patients free of disease after 3 years and 11 patients with recurrence) were stained histoimmunochemically for factor VIII-related antigens. Vessel counting in the most active area of angiogenesis was performed by two pathologists on a x 200 microscopic field (0.739 mm2) without knowledge of the patients' outcome. To predict recurrence, vessel count was compared with age, tumor size, tumor grade, lymph-vascular invasion, duration of follow-up, and type of therapy.
Only high microvessel count (mean 19.9, range 7–43, versus mean 30.1, range 17–78; P < .05) and tumor size (mean 2.84 cm, range 1–4.2, versus mean 4.11 cm, range 2.2–6; P < .05) were independent factors predicting recurrence.
High microvessel count in tumors may be used to predict recurrence in stage Ib squamous cell carcinoma of the cervix.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1016/0029-7844(96)00039-7</identifier><identifier>PMID: 8677080</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; Cervix Uteri - blood supply ; Cervix Uteri - pathology ; Female ; Female genital diseases ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Immunoenzyme Techniques ; Medical sciences ; Neoplasm Recurrence, Local - epidemiology ; Neoplasm Staging ; Neovascularization, Pathologic - pathology ; Time Factors ; Tumors ; Uterine Cervical Neoplasms - blood supply ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - pathology ; von Willebrand Factor - analysis</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1996-05, Vol.87 (5), p.751-754</ispartof><rights>1996 The American College of Obstetricians and Gynecologists</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-27e1606f44e099c9de39610049e3ea70854f3bc60d41dc1927d2205b817e842e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3066269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8677080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dinh, Tung V.</creatorcontrib><creatorcontrib>Hannigan, Edward V.</creatorcontrib><creatorcontrib>Smith, Edward R.</creatorcontrib><creatorcontrib>Hove, Maxwell J.</creatorcontrib><creatorcontrib>Chopra, Vimlarani</creatorcontrib><creatorcontrib>To, Tonia</creatorcontrib><title>Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To explore the possibility of using histologic microvessel count of sections from the tumor to predict recurrence of stage Ib squamous cell carcinoma of the cervix.
Tumor sections from 22 patients (11 patients free of disease after 3 years and 11 patients with recurrence) were stained histoimmunochemically for factor VIII-related antigens. Vessel counting in the most active area of angiogenesis was performed by two pathologists on a x 200 microscopic field (0.739 mm2) without knowledge of the patients' outcome. To predict recurrence, vessel count was compared with age, tumor size, tumor grade, lymph-vascular invasion, duration of follow-up, and type of therapy.
Only high microvessel count (mean 19.9, range 7–43, versus mean 30.1, range 17–78; P < .05) and tumor size (mean 2.84 cm, range 1–4.2, versus mean 4.11 cm, range 2.2–6; P < .05) were independent factors predicting recurrence.
High microvessel count in tumors may be used to predict recurrence in stage Ib squamous cell carcinoma of the cervix.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - blood supply</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervix Uteri - blood supply</subject><subject>Cervix Uteri - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Time Factors</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - blood supply</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>von Willebrand Factor - analysis</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1qGzEUhUVJcR23b9CCFiUki0muRrJ-NoViktRgyMaB7oSsueOqeGZsaSYkbx8NNl4GBOLqnHM5-gj5zuCWAZN3AKUplBbi2sgbAOB5-kSmTCtelJz_vSDTs-ULuUzpfzYxafiETLRUCjRMiVsPTRepa7eh22KLKSTq8qH7iFXwfda6mkb0Q4zYeqShpal3W6TLDU2HwTXdkKjH3Y56F31ou8aNif4f5tf4El6_ks-12yX8drpn5Pnhfr34U6yeHpeL36vCcy36olTIJMhaCARjvKmQG8kAhEGOLpedi5pvvIRKsMozU6qqLGG-0UyhFiXyGbk67t3H7jBg6m0T0ljMtZg7WqXz9-dCZ6M4Gn3sUopY230MjYtvloEdydoRmx2xWTMOmaxVOfbjtH_YNFidQyeUWf950l3ybldH1_qQzjYOUpYZ_oz8Otows3gJGG3yYSRbhUy5t1UXPu7xDpkBk_o</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>Dinh, Tung V.</creator><creator>Hannigan, Edward V.</creator><creator>Smith, Edward R.</creator><creator>Hove, Maxwell J.</creator><creator>Chopra, Vimlarani</creator><creator>To, Tonia</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix</title><author>Dinh, Tung V. ; Hannigan, Edward V. ; Smith, Edward R. ; Hove, Maxwell J. ; Chopra, Vimlarani ; To, Tonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-27e1606f44e099c9de39610049e3ea70854f3bc60d41dc1927d2205b817e842e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - blood supply</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervix Uteri - blood supply</topic><topic>Cervix Uteri - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neoplasm Staging</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Time Factors</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - blood supply</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>von Willebrand Factor - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dinh, Tung V.</creatorcontrib><creatorcontrib>Hannigan, Edward V.</creatorcontrib><creatorcontrib>Smith, Edward R.</creatorcontrib><creatorcontrib>Hove, Maxwell J.</creatorcontrib><creatorcontrib>Chopra, Vimlarani</creatorcontrib><creatorcontrib>To, Tonia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dinh, Tung V.</au><au>Hannigan, Edward V.</au><au>Smith, Edward R.</au><au>Hove, Maxwell J.</au><au>Chopra, Vimlarani</au><au>To, Tonia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>87</volume><issue>5</issue><spage>751</spage><epage>754</epage><pages>751-754</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To explore the possibility of using histologic microvessel count of sections from the tumor to predict recurrence of stage Ib squamous cell carcinoma of the cervix.
Tumor sections from 22 patients (11 patients free of disease after 3 years and 11 patients with recurrence) were stained histoimmunochemically for factor VIII-related antigens. Vessel counting in the most active area of angiogenesis was performed by two pathologists on a x 200 microscopic field (0.739 mm2) without knowledge of the patients' outcome. To predict recurrence, vessel count was compared with age, tumor size, tumor grade, lymph-vascular invasion, duration of follow-up, and type of therapy.
Only high microvessel count (mean 19.9, range 7–43, versus mean 30.1, range 17–78; P < .05) and tumor size (mean 2.84 cm, range 1–4.2, versus mean 4.11 cm, range 2.2–6; P < .05) were independent factors predicting recurrence.
High microvessel count in tumors may be used to predict recurrence in stage Ib squamous cell carcinoma of the cervix.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8677080</pmid><doi>10.1016/0029-7844(96)00039-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1996-05, Vol.87 (5), p.751-754 |
| issn | 0029-7844 1873-233X |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Biological and medical sciences Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology Cervix Uteri - blood supply Cervix Uteri - pathology Female Female genital diseases Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Immunoenzyme Techniques Medical sciences Neoplasm Recurrence, Local - epidemiology Neoplasm Staging Neovascularization, Pathologic - pathology Time Factors Tumors Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - pathology von Willebrand Factor - analysis |
| title | Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix |
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