Sphingosine-1-phosphate inhibits actin nucleation and pseudopodium formation to control cell motility of mouse melanoma cells

Sphingosine-1-phosphate (Sph-1-P), the initial product of sphingosine (Sph) catabolism, has been reported to inhibit motility of mouse melanoma B16/F1 and other types of cells at very low concentrations (10–100 nM). Sph-1-P (100 nM–1 μM) inhibited pseudopodium formation by blocking polymerization an...

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Veröffentlicht in:	FEBS letters 1996-03, Vol.382 (1), p.193-197
Hauptverfasser:	Yamamura, Soichiro, Sadahira, Yoshito, Ruan, Fuqiang, Hakomori, Sen-itiroh, Igarashi, Yasuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	12-O-tetradecanoylphorbol 13-acetate Actin nucleation Actins - metabolism Animals C2-Cer C2-ceramide (N-acetyl sphingosine) Calcium - metabolism Cell Membrane - metabolism Cell motility Cell Movement - drug effects conditioned medium Culture Media, Conditioned - pharmacology DMEM DMS DMS-1-P Dulbecco's modified Eagle's medium EDTA ethylenediaminetetraacetic acid Lysophospholipids Melanoma Mice N,N,N-trimethylsphingosine N,N-dimethylsphingosine N,N-dimethylsphingosine-1-phosphate N,N-trimethylsphingosine-1-phosphate PBS phosphate-buffered saline Pseudopodia - drug effects Pseudopodium SPC Sph Sph-1-P sphingosine Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine-1-phosphate sphingosylphosphorylcholine TMS TMS-1-P TPA Tumor Cells, Cultured
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