Ascorbate synthesis-dependent glutathione consumption in mouse liver

Ascorbate synthesis causes glutathione consumption in the liver. Addition of gulonolactone resulted in an increase of ascorbate production in isolated murine hepatocytes. At the same time, a decrease in reduced glutathione (GSH) level was observed. In hepatic microsomal membranes, ascorbate synthesi...

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Veröffentlicht in:	FEBS letters 1996-02, Vol.381 (1), p.39-41
Hauptverfasser:	Bánhegyi, Gábor, Csala, Miklós, Braun, László, Garzó, Tamás, Mandl, József
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitrole - pharmacology Animals Ascorbic acid Ascorbic Acid - biosynthesis Catalase - pharmacology Cells, Cultured Evolution Glutathione Glutathione - metabolism Gulonolactone oxidase Hydrogen peroxide Kinetics Liver - drug effects Liver - metabolism Male Mice Mice, Inbred Strains Microsomes, Liver - drug effects Microsomes, Liver - metabolism Mouse liver Sugar Acids - pharmacology
Online-Zugang:	Volltext
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