A Structure−Activity Relationship Study of Novel Phenylacetamides Which Are Sodium Channel Blockers

A structure−activity relationship study of a series of novel Na+ channel blockers, structurally related to N-[3-(2,6-dimethyl-1-piperidinyl)propyl]-α-phenylbenzeneacetamide (1, PD85639) is described. The diphenylacetic acid portion of the molecule was left unchanged throughout the study, while struc...

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Veröffentlicht in:	Journal of medicinal chemistry 1996-03, Vol.39 (7), p.1514-1520
Hauptverfasser:	Roufos, Ioannis, Hays, Sheryl, Schwarz, Roy D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - chemical synthesis Acetamides - chemistry Acetamides - pharmacology Animals Benzeneacetamides Biological and medical sciences CHO Cells Cricetinae Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Piperidines - chemistry Piperidines - pharmacology Sodium - metabolism Sodium Channel Blockers Sodium Channels - metabolism Structure-Activity Relationship Veratridine - pharmacology
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