Induction of muscle protein degradation and weight loss by a tumor product

Splenocytes from mice bearing a cachexia-inducing tumor (MAC16) have been fused with mouse myeloma cells to produce hybridomas, which have been cloned to produce antibody reactive to a material which copurified with a lipid-mobilizing factor isolated from the same tumor. The monoclonal antibody has...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-03, Vol.56 (6), p.1256-1261
Hauptverfasser:	TODOROV, P. T, MCDEVITT, T. M, CARIUK, P, COLES, B, DEACON, M, TISDALE, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - pharmacology Biological and medical sciences Blotting, Western Cachexia - etiology Cell Fusion Glycoproteins - antagonists & inhibitors Glycoproteins - chemistry Glycoproteins - immunology Glycoproteins - isolation & purification Glycoproteins - pharmacology Hybridomas - immunology Medical sciences Mice Molecular Weight Multiple Myeloma - immunology Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Muscle Proteins - drug effects Muscle Proteins - metabolism Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - chemistry Neoplasm Proteins - immunology Neoplasm Proteins - isolation & purification Neoplasm Proteins - pharmacology Neoplasms - complications Neoplasms - metabolism Spleen - cytology Tumors
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