Characterization of genes encoding topoisomerase IV of Mycoplasma genitalium
A type-II topoisomerase (Topo-IV) encoded by the parC and parE genes in Escherichia coli and Salmonella typhimurium is thought to be involvd in cell septation and in the decatenation of newly replicated chromosomes. We have identified parC and parE homologs in the pleomorphic, wall-less organism Myc...
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| Veröffentlicht in: | Gene 1996-02, Vol.168 (1), p.77-80 |
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| creator | Bailey, Camella C. Younkins, Ronsha Wai Mun Huang Bott, Kenneth F. |
| description | A type-II topoisomerase (Topo-IV) encoded by the
parC and
parE genes in
Escherichia coli and
Salmonella typhimurium is thought to be involvd in cell septation and in the decatenation of newly replicated chromosomes. We have identified
parC and
parE homologs in the pleomorphic, wall-less organism
Mycoplasma genitalium. Since the mechanics of cell septation in conventional eubacterial species is believed to be mediated by cell-wall constituents, there is no clear understanding of what coordinates that process in wall-less species. The presence of
par genes in this bacterium, which has the smallest genome of any free-living organism, suggests that Top-IV has been evolutionarily conserved because of an essential role in mediating cell division. |
| doi_str_mv | 10.1016/0378-1119(95)00718-0 |
| format | Article |
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parC and
parE genes in
Escherichia coli and
Salmonella typhimurium is thought to be involvd in cell septation and in the decatenation of newly replicated chromosomes. We have identified
parC and
parE homologs in the pleomorphic, wall-less organism
Mycoplasma genitalium. Since the mechanics of cell septation in conventional eubacterial species is believed to be mediated by cell-wall constituents, there is no clear understanding of what coordinates that process in wall-less species. The presence of
par genes in this bacterium, which has the smallest genome of any free-living organism, suggests that Top-IV has been evolutionarily conserved because of an essential role in mediating cell division.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/0378-1119(95)00718-0</identifier><identifier>PMID: 8626069</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Bacterial Proteins - genetics ; Cell division ; Cell Division - genetics ; Cell Wall - metabolism ; Chromosome Mapping ; cloning ; Cloning, Molecular ; DNA Gyrase ; DNA Topoisomerase IV ; DNA Topoisomerases, Type II - genetics ; DNA-Binding Proteins - genetics ; Escherichia coli ; Evolution, Molecular ; Genes, Bacterial ; genome partitioning ; Mollicutes ; Mycoplasma - enzymology ; Mycoplasma - genetics ; Mycoplasma genitalium ; Open Reading Frames - genetics ; Salmonella typhimurium ; Sequence Homology, Nucleic Acid</subject><ispartof>Gene, 1996-02, Vol.168 (1), p.77-80</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-4137bfedaa01fb3e216f0cf2ca60a211cdc2cfa215b157aa30280b6848609da3</citedby><cites>FETCH-LOGICAL-c388t-4137bfedaa01fb3e216f0cf2ca60a211cdc2cfa215b157aa30280b6848609da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-1119(95)00718-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8626069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bailey, Camella C.</creatorcontrib><creatorcontrib>Younkins, Ronsha</creatorcontrib><creatorcontrib>Wai Mun Huang</creatorcontrib><creatorcontrib>Bott, Kenneth F.</creatorcontrib><title>Characterization of genes encoding topoisomerase IV of Mycoplasma genitalium</title><title>Gene</title><addtitle>Gene</addtitle><description>A type-II topoisomerase (Topo-IV) encoded by the
parC and
parE genes in
Escherichia coli and
Salmonella typhimurium is thought to be involvd in cell septation and in the decatenation of newly replicated chromosomes. We have identified
parC and
parE homologs in the pleomorphic, wall-less organism
Mycoplasma genitalium. Since the mechanics of cell septation in conventional eubacterial species is believed to be mediated by cell-wall constituents, there is no clear understanding of what coordinates that process in wall-less species. The presence of
par genes in this bacterium, which has the smallest genome of any free-living organism, suggests that Top-IV has been evolutionarily conserved because of an essential role in mediating cell division.</description><subject>Bacterial Proteins - genetics</subject><subject>Cell division</subject><subject>Cell Division - genetics</subject><subject>Cell Wall - metabolism</subject><subject>Chromosome Mapping</subject><subject>cloning</subject><subject>Cloning, Molecular</subject><subject>DNA Gyrase</subject><subject>DNA Topoisomerase IV</subject><subject>DNA Topoisomerases, Type II - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Escherichia coli</subject><subject>Evolution, Molecular</subject><subject>Genes, Bacterial</subject><subject>genome partitioning</subject><subject>Mollicutes</subject><subject>Mycoplasma - enzymology</subject><subject>Mycoplasma - genetics</subject><subject>Mycoplasma genitalium</subject><subject>Open Reading Frames - genetics</subject><subject>Salmonella typhimurium</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3EAMQIfQkG63-YMUfCrpwYnkWY_Hl0JZ0mZhQy6h10Eey-kU27OdsQPbr4-dXXJMdJGQniR4QlwgXCGgugZZ6BQRy8sy_wZQoE7hRCxQF2UKIPUHsXhFPopPMf6FKfI8OxNnWmUKVLkQ2_UfCmQHDu4_Dc73iW-SR-45JtxbX7v-MRn8zrvoOw4UOdn8npG7vfW7lmJHM-0Gat3YfRanDbWRz495KR5-3jysb9Pt_a_N-sc2tVLrIV2hLKqGayLAppKcoWrANpklBZQh2tpmtpmqvMK8IJKQaaiUXmkFZU1yKb4ezu6C_zdyHEznouW2pZ79GE1RlKWUKnsXxAJwUjSDqwNog48xcGN2wXUU9gbBzLLNbNLMJk2ZmxfZU2spvhzvj1XH9evS0e40_36Y8yTjyXEw0bpJK9cusB1M7d3bD54By1aOgg</recordid><startdate>19960202</startdate><enddate>19960202</enddate><creator>Bailey, Camella C.</creator><creator>Younkins, Ronsha</creator><creator>Wai Mun Huang</creator><creator>Bott, Kenneth F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TM</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19960202</creationdate><title>Characterization of genes encoding topoisomerase IV of Mycoplasma genitalium</title><author>Bailey, Camella C. ; Younkins, Ronsha ; Wai Mun Huang ; Bott, Kenneth F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-4137bfedaa01fb3e216f0cf2ca60a211cdc2cfa215b157aa30280b6848609da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Bacterial Proteins - genetics</topic><topic>Cell division</topic><topic>Cell Division - genetics</topic><topic>Cell Wall - metabolism</topic><topic>Chromosome Mapping</topic><topic>cloning</topic><topic>Cloning, Molecular</topic><topic>DNA Gyrase</topic><topic>DNA Topoisomerase IV</topic><topic>DNA Topoisomerases, Type II - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Escherichia coli</topic><topic>Evolution, Molecular</topic><topic>Genes, Bacterial</topic><topic>genome partitioning</topic><topic>Mollicutes</topic><topic>Mycoplasma - enzymology</topic><topic>Mycoplasma - genetics</topic><topic>Mycoplasma genitalium</topic><topic>Open Reading Frames - genetics</topic><topic>Salmonella typhimurium</topic><topic>Sequence Homology, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bailey, Camella C.</creatorcontrib><creatorcontrib>Younkins, Ronsha</creatorcontrib><creatorcontrib>Wai Mun Huang</creatorcontrib><creatorcontrib>Bott, Kenneth F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bailey, Camella C.</au><au>Younkins, Ronsha</au><au>Wai Mun Huang</au><au>Bott, Kenneth F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of genes encoding topoisomerase IV of Mycoplasma genitalium</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1996-02-02</date><risdate>1996</risdate><volume>168</volume><issue>1</issue><spage>77</spage><epage>80</epage><pages>77-80</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>A type-II topoisomerase (Topo-IV) encoded by the
parC and
parE genes in
Escherichia coli and
Salmonella typhimurium is thought to be involvd in cell septation and in the decatenation of newly replicated chromosomes. We have identified
parC and
parE homologs in the pleomorphic, wall-less organism
Mycoplasma genitalium. Since the mechanics of cell septation in conventional eubacterial species is believed to be mediated by cell-wall constituents, there is no clear understanding of what coordinates that process in wall-less species. The presence of
par genes in this bacterium, which has the smallest genome of any free-living organism, suggests that Top-IV has been evolutionarily conserved because of an essential role in mediating cell division.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8626069</pmid><doi>10.1016/0378-1119(95)00718-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Gene, 1996-02, Vol.168 (1), p.77-80 |
| issn | 0378-1119 1879-0038 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Bacterial Proteins - genetics Cell division Cell Division - genetics Cell Wall - metabolism Chromosome Mapping cloning Cloning, Molecular DNA Gyrase DNA Topoisomerase IV DNA Topoisomerases, Type II - genetics DNA-Binding Proteins - genetics Escherichia coli Evolution, Molecular Genes, Bacterial genome partitioning Mollicutes Mycoplasma - enzymology Mycoplasma - genetics Mycoplasma genitalium Open Reading Frames - genetics Salmonella typhimurium Sequence Homology, Nucleic Acid |
| title | Characterization of genes encoding topoisomerase IV of Mycoplasma genitalium |
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