Genetic Basis of Hypo-Responsiveness of A/J Mice to Interleukin-3

Hematopoietic progenitor cells of the A/J strain of mice show a pronounced defect in the ability to form colonies or proliferate in response to interleukin-3 (IL-3). Comparison of immunoblots of A/J mast cells and of mast cells from the C57BL/6 strain that respond normally to IL-3 showed that, in bo...

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Veröffentlicht in:	Blood 1996-04, Vol.87 (8), p.3186-3194
Hauptverfasser:	Leslie, Kevin B., Jalbert, Sheila, Orban, Paul, Welham, Melanie, Duronio, Vincent, Schrader, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells, Cultured Chromosome Mapping Fundamental and applied biological sciences. Psychology Gene Expression Hematopoiesis - drug effects Hematopoietic Stem Cells - drug effects Interleukin-3 - pharmacology Mice Mice, Inbred A - genetics Mice, Inbred C57BL Mice, Inbred DBA Molecular and cellular biology Molecular Sequence Data Polymorphism, Genetic Receptors, Interleukin-3 - chemistry Receptors, Interleukin-3 - deficiency Receptors, Interleukin-3 - drug effects Receptors, Interleukin-3 - genetics Recombinant Proteins - pharmacology Signal Transduction - drug effects Species Specificity Stem Cell Factor - pharmacology
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