Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I

To evaluate the association of autoimmunity to glutamic acid decarboxylase (GAD) with insulin-dependent diabetes mellitus (IDDM) and IDDM-associated human leukocyte antigen (HLA) types, we studied a unique group of 47 patients with autoimmune polyendocrine syndrome type 1, a recessive disease not as...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 1996-04, Vol.81 (4), p.1488-1494
Hauptverfasser:	TUOMI, T, BJÖRSES, P, FALORNI, A, PARTANEN, J, PERHEENTUPA, J, LERNMARK, A, MIETTINEN, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Autoantibodies - blood Biological and medical sciences C-Peptide - blood Child Child, Preschool Diabetes Mellitus, Type 1 - immunology Endocrinopathies Female Follow-Up Studies General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes Genes, MHC Class II Genotype Glutamate Decarboxylase - immunology Histocompatibility Testing HLA-DQ alpha-Chains HLA-DQ Antigens - blood HLA-DQ beta-Chains HLA-DR Antigens - blood HLA-DRB1 Chains Humans Infant Insulin - blood Insulin - metabolism Insulin Secretion Islets of Langerhans - immunology Islets of Langerhans - metabolism Male Medical sciences Middle Aged Polyendocrinopathies, Autoimmune - blood Polyendocrinopathies, Autoimmune - diagnosis Polyendocrinopathies, Autoimmune - immunology Polymerase Chain Reaction
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