Adenosine infusion improves oxygenation in term infants with respiratory failure
Adenosine infusion causes selective pulmonary vasodilation in fetal and neonatal lambs with pulmonary hypertension. We investigated the effects of a continuous infusion of adenosine on oxygenation in term infants with persistent pulmonary hypertension of newborn (PPHN). A randomized, placebo-control...
Gespeichert in:
| Veröffentlicht in: | Pediatrics (Evanston) 1996-03, Vol.97 (3), p.295-300 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 300 |
|---|---|
| container_issue | 3 |
| container_start_page | 295 |
| container_title | Pediatrics (Evanston) |
| container_volume | 97 |
| creator | KONDURI, G. G GARCIA, D. C KAZZI, N. J SHANKARAN, S |
| description | Adenosine infusion causes selective pulmonary vasodilation in fetal and neonatal lambs with pulmonary hypertension. We investigated the effects of a continuous infusion of adenosine on oxygenation in term infants with persistent pulmonary hypertension of newborn (PPHN).
A randomized, placebo-controlled, masked trial comparing the efficacy of intravenous infusion of adenosine to normal saline infusion over a 24-hour period.
Inborn and outborn level III neonatal intensive care units at a university medical center.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 |
| doi_str_mv | 10.1542/peds.97.3.295 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_77987689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A18127763</galeid><sourcerecordid>A18127763</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-16268024e4eba2bf230babcaadf9cea8eddfc984e00da7fe5e975898a572540d3</originalsourceid><addsrcrecordid>eNpt0kGLEzEUB_AgylpXjx6FQUQ87NRMJjNJjqXoKhTWg57Da-alZplJapLR7bc3dcvCSskhkPcjvPf4E_K6ocum4-zjHoe0VGLZLpnqnpBFQ5WsORPdU7KgtG1qTmn3nLxI6ZZSyjvBLsiF7ClnPV2Qb6sBfUjOY-W8nZMLvnLTPobfmKpwd9ihh_zv0VcZ43RU4HOq_rj8s4qY9i5CDvFQWXDjHPEleWZhTPjqdF-SH58_fV9_qTc311_Xq01tuFS5bnrWS8o4ctwC21rW0i1sDcBglUGQOAzWKMmR0gGExQ6V6KSSUPrvOB3aS_L-_t_S668ZU9aTSwbHETyGOWkhlBS9VAW-_Q_ehjn60ptmTLaNokwUdHWPdjCiLjOGHMGU4THCGDxaV55XjWyYEH1beH2GlzPg5Mw5_-GRLyTjXd7BnJKW15tH9OocNWEccYe67HB9c64TE0NKEa3eRzdBPOiG6mM-9DEfWgnd6pKP4t-ctjFvJxwe9CkQpf7uVIdkYLQRvHHpgbVU8Z7T9i-5XsKH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>228319027</pqid></control><display><type>article</type><title>Adenosine infusion improves oxygenation in term infants with respiratory failure</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>KONDURI, G. G ; GARCIA, D. C ; KAZZI, N. J ; SHANKARAN, S</creator><creatorcontrib>KONDURI, G. G ; GARCIA, D. C ; KAZZI, N. J ; SHANKARAN, S</creatorcontrib><description>Adenosine infusion causes selective pulmonary vasodilation in fetal and neonatal lambs with pulmonary hypertension. We investigated the effects of a continuous infusion of adenosine on oxygenation in term infants with persistent pulmonary hypertension of newborn (PPHN).
A randomized, placebo-controlled, masked trial comparing the efficacy of intravenous infusion of adenosine to normal saline infusion over a 24-hour period.
Inborn and outborn level III neonatal intensive care units at a university medical center.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 <30 Torr) were enrolled into the study. Study infants were randomly assigned to receive a placebo infusion of normal saline, or adenosine infusion in doses of 25 to 50 microg/kg/min over a 24-hour period.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 <30 Torr) were enrolled into the study. Study infants were randomly assigned to receive a placebo infusion of normal saline, or adenosine infusion in doses of 25 to 50 microg/kg/min over a 24-hour period.
Nine infants each received adenosine or placebo. The two groups did not differ in birth weight, gestational age, or blood gases and ventilaator requirements at the time of entry into the study. Four of nine infants in the adenosine group and none of the placebo group had a significant improvement in oxygenation, defined as an increase in postductal PaO2 of > or =20 Torr from preinfusion baseline. The mean PaO2 in the adenosine group increased from 69 +/- 19 at baseline to 94 +/- 15 during 50 microg/kg/min infusion rate of adenossine and did not change significantly in the placebo group. Arterial blood pressure and heart rate did not change during the study in either group. The need for extracorporeal membrane oxygenation, incidence of bronchopulmonary dysplasia, and mortality were not different in the two groups.
Data from this pilot study indicate that adenosine infusion at a dose of 50 microg/kg/min improves PaO2 in infants with PPHN without causing hypotension or tachycardia. Larger trials are needed to determine its effects on mortality and/or need for extracorporeal membrane oxygenation in infants with PPHN.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.97.3.295</identifier><identifier>PMID: 8604260</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Adenosine ; Adenosine - pharmacology ; Adenosine - therapeutic use ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Babies ; Biological and medical sciences ; Blood Pressure - drug effects ; Care and treatment ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Female ; Health aspects ; Heart Rate - drug effects ; Humans ; Infant, Newborn ; Infusions, Intravenous ; Intensive care medicine ; Male ; Medical sciences ; Oxygen ; Oxygen - blood ; Pediatrics ; Persistent fetal circulation syndrome ; Persistent Fetal Circulation Syndrome - complications ; Pilot Projects ; Respiration, Artificial ; Respiratory Insufficiency - blood ; Respiratory Insufficiency - drug therapy ; Respiratory Insufficiency - etiology ; Respiratory system ; Vasodilator Agents - pharmacology ; Vasodilator Agents - therapeutic use</subject><ispartof>Pediatrics (Evanston), 1996-03, Vol.97 (3), p.295-300</ispartof><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Academy of Pediatrics</rights><rights>COPYRIGHT 1996 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Mar 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-16268024e4eba2bf230babcaadf9cea8eddfc984e00da7fe5e975898a572540d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3094640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8604260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KONDURI, G. G</creatorcontrib><creatorcontrib>GARCIA, D. C</creatorcontrib><creatorcontrib>KAZZI, N. J</creatorcontrib><creatorcontrib>SHANKARAN, S</creatorcontrib><title>Adenosine infusion improves oxygenation in term infants with respiratory failure</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Adenosine infusion causes selective pulmonary vasodilation in fetal and neonatal lambs with pulmonary hypertension. We investigated the effects of a continuous infusion of adenosine on oxygenation in term infants with persistent pulmonary hypertension of newborn (PPHN).
A randomized, placebo-controlled, masked trial comparing the efficacy of intravenous infusion of adenosine to normal saline infusion over a 24-hour period.
Inborn and outborn level III neonatal intensive care units at a university medical center.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 <30 Torr) were enrolled into the study. Study infants were randomly assigned to receive a placebo infusion of normal saline, or adenosine infusion in doses of 25 to 50 microg/kg/min over a 24-hour period.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 <30 Torr) were enrolled into the study. Study infants were randomly assigned to receive a placebo infusion of normal saline, or adenosine infusion in doses of 25 to 50 microg/kg/min over a 24-hour period.
Nine infants each received adenosine or placebo. The two groups did not differ in birth weight, gestational age, or blood gases and ventilaator requirements at the time of entry into the study. Four of nine infants in the adenosine group and none of the placebo group had a significant improvement in oxygenation, defined as an increase in postductal PaO2 of > or =20 Torr from preinfusion baseline. The mean PaO2 in the adenosine group increased from 69 +/- 19 at baseline to 94 +/- 15 during 50 microg/kg/min infusion rate of adenossine and did not change significantly in the placebo group. Arterial blood pressure and heart rate did not change during the study in either group. The need for extracorporeal membrane oxygenation, incidence of bronchopulmonary dysplasia, and mortality were not different in the two groups.
Data from this pilot study indicate that adenosine infusion at a dose of 50 microg/kg/min improves PaO2 in infants with PPHN without causing hypotension or tachycardia. Larger trials are needed to determine its effects on mortality and/or need for extracorporeal membrane oxygenation in infants with PPHN.</description><subject>Adenosine</subject><subject>Adenosine - pharmacology</subject><subject>Adenosine - therapeutic use</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Babies</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Care and treatment</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Female</subject><subject>Health aspects</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infusions, Intravenous</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxygen</subject><subject>Oxygen - blood</subject><subject>Pediatrics</subject><subject>Persistent fetal circulation syndrome</subject><subject>Persistent Fetal Circulation Syndrome - complications</subject><subject>Pilot Projects</subject><subject>Respiration, Artificial</subject><subject>Respiratory Insufficiency - blood</subject><subject>Respiratory Insufficiency - drug therapy</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Respiratory system</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0kGLEzEUB_AgylpXjx6FQUQ87NRMJjNJjqXoKhTWg57Da-alZplJapLR7bc3dcvCSskhkPcjvPf4E_K6ocum4-zjHoe0VGLZLpnqnpBFQ5WsORPdU7KgtG1qTmn3nLxI6ZZSyjvBLsiF7ClnPV2Qb6sBfUjOY-W8nZMLvnLTPobfmKpwd9ihh_zv0VcZ43RU4HOq_rj8s4qY9i5CDvFQWXDjHPEleWZhTPjqdF-SH58_fV9_qTc311_Xq01tuFS5bnrWS8o4ctwC21rW0i1sDcBglUGQOAzWKMmR0gGExQ6V6KSSUPrvOB3aS_L-_t_S668ZU9aTSwbHETyGOWkhlBS9VAW-_Q_ehjn60ptmTLaNokwUdHWPdjCiLjOGHMGU4THCGDxaV55XjWyYEH1beH2GlzPg5Mw5_-GRLyTjXd7BnJKW15tH9OocNWEccYe67HB9c64TE0NKEa3eRzdBPOiG6mM-9DEfWgnd6pKP4t-ctjFvJxwe9CkQpf7uVIdkYLQRvHHpgbVU8Z7T9i-5XsKH</recordid><startdate>19960301</startdate><enddate>19960301</enddate><creator>KONDURI, G. G</creator><creator>GARCIA, D. C</creator><creator>KAZZI, N. J</creator><creator>SHANKARAN, S</creator><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>19960301</creationdate><title>Adenosine infusion improves oxygenation in term infants with respiratory failure</title><author>KONDURI, G. G ; GARCIA, D. C ; KAZZI, N. J ; SHANKARAN, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-16268024e4eba2bf230babcaadf9cea8eddfc984e00da7fe5e975898a572540d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenosine</topic><topic>Adenosine - pharmacology</topic><topic>Adenosine - therapeutic use</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Babies</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Care and treatment</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Female</topic><topic>Health aspects</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infusions, Intravenous</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxygen</topic><topic>Oxygen - blood</topic><topic>Pediatrics</topic><topic>Persistent fetal circulation syndrome</topic><topic>Persistent Fetal Circulation Syndrome - complications</topic><topic>Pilot Projects</topic><topic>Respiration, Artificial</topic><topic>Respiratory Insufficiency - blood</topic><topic>Respiratory Insufficiency - drug therapy</topic><topic>Respiratory Insufficiency - etiology</topic><topic>Respiratory system</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KONDURI, G. G</creatorcontrib><creatorcontrib>GARCIA, D. C</creatorcontrib><creatorcontrib>KAZZI, N. J</creatorcontrib><creatorcontrib>SHANKARAN, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KONDURI, G. G</au><au>GARCIA, D. C</au><au>KAZZI, N. J</au><au>SHANKARAN, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenosine infusion improves oxygenation in term infants with respiratory failure</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1996-03-01</date><risdate>1996</risdate><volume>97</volume><issue>3</issue><spage>295</spage><epage>300</epage><pages>295-300</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Adenosine infusion causes selective pulmonary vasodilation in fetal and neonatal lambs with pulmonary hypertension. We investigated the effects of a continuous infusion of adenosine on oxygenation in term infants with persistent pulmonary hypertension of newborn (PPHN).
A randomized, placebo-controlled, masked trial comparing the efficacy of intravenous infusion of adenosine to normal saline infusion over a 24-hour period.
Inborn and outborn level III neonatal intensive care units at a university medical center.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 <30 Torr) were enrolled into the study. Study infants were randomly assigned to receive a placebo infusion of normal saline, or adenosine infusion in doses of 25 to 50 microg/kg/min over a 24-hour period.
Eighteen term infants with PPHN and arterial postductal PO2 of 60 to 100 Torr on inspired O2 concentration of 100% and optimal hyperventilation (PaCO2 <30 Torr) were enrolled into the study. Study infants were randomly assigned to receive a placebo infusion of normal saline, or adenosine infusion in doses of 25 to 50 microg/kg/min over a 24-hour period.
Nine infants each received adenosine or placebo. The two groups did not differ in birth weight, gestational age, or blood gases and ventilaator requirements at the time of entry into the study. Four of nine infants in the adenosine group and none of the placebo group had a significant improvement in oxygenation, defined as an increase in postductal PaO2 of > or =20 Torr from preinfusion baseline. The mean PaO2 in the adenosine group increased from 69 +/- 19 at baseline to 94 +/- 15 during 50 microg/kg/min infusion rate of adenossine and did not change significantly in the placebo group. Arterial blood pressure and heart rate did not change during the study in either group. The need for extracorporeal membrane oxygenation, incidence of bronchopulmonary dysplasia, and mortality were not different in the two groups.
Data from this pilot study indicate that adenosine infusion at a dose of 50 microg/kg/min improves PaO2 in infants with PPHN without causing hypotension or tachycardia. Larger trials are needed to determine its effects on mortality and/or need for extracorporeal membrane oxygenation in infants with PPHN.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>8604260</pmid><doi>10.1542/peds.97.3.295</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 1996-03, Vol.97 (3), p.295-300 |
| issn | 0031-4005 1098-4275 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77987689 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenosine Adenosine - pharmacology Adenosine - therapeutic use Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Babies Biological and medical sciences Blood Pressure - drug effects Care and treatment Emergency and intensive care: neonates and children. Prematurity. Sudden death Female Health aspects Heart Rate - drug effects Humans Infant, Newborn Infusions, Intravenous Intensive care medicine Male Medical sciences Oxygen Oxygen - blood Pediatrics Persistent fetal circulation syndrome Persistent Fetal Circulation Syndrome - complications Pilot Projects Respiration, Artificial Respiratory Insufficiency - blood Respiratory Insufficiency - drug therapy Respiratory Insufficiency - etiology Respiratory system Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use |
| title | Adenosine infusion improves oxygenation in term infants with respiratory failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T01%3A23%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adenosine%20infusion%20improves%20oxygenation%20in%20term%20infants%20with%20respiratory%20failure&rft.jtitle=Pediatrics%20(Evanston)&rft.au=KONDURI,%20G.%20G&rft.date=1996-03-01&rft.volume=97&rft.issue=3&rft.spage=295&rft.epage=300&rft.pages=295-300&rft.issn=0031-4005&rft.eissn=1098-4275&rft.coden=PEDIAU&rft_id=info:doi/10.1542/peds.97.3.295&rft_dat=%3Cgale_proqu%3EA18127763%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=228319027&rft_id=info:pmid/8604260&rft_galeid=A18127763&rfr_iscdi=true |