Beta-2 transferrin : limitations of use as a clinical marker for perilymph
Beta-2 transferrin is a protein marker that can be used in the clinical setting to reliably identify the presence of cerebrospinal fluid (CSF). Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph. This study investigates the use of a beta-2 tra...
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| Veröffentlicht in: | The Laryngoscope 1996-02, Vol.106 (2), p.159-161 |
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| container_title | The Laryngoscope |
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| creator | LEVENSON, M. J DESLOGE, R. B PARISIER, S. C |
| description | Beta-2 transferrin is a protein marker that can be used in the clinical setting to reliably identify the presence of cerebrospinal fluid (CSF). Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph. This study investigates the use of a beta-2 transferrin assay as a method to identify the presence of perilymph. Twenty-two patients were enrolled in the study. Fluid samples were obtained intraoperatively and tested for the presence of beta-2 transferrin. As expected, four CSF samples collected were positive for beta-2 transferrin; however, four known perilymph samples collected from patients undergoing cochlear implantation were negative for beta-2 transferrin, seven of nine known perilymph samples obtained during stapedectomies were negative for beta-2 transferrin, and four of five samples collected during middle ear explorations for fistula were negative for beta-2 transferrin. With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting. |
| doi_str_mv | 10.1097/00005537-199602000-00010 |
| format | Article |
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As expected, four CSF samples collected were positive for beta-2 transferrin; however, four known perilymph samples collected from patients undergoing cochlear implantation were negative for beta-2 transferrin, seven of nine known perilymph samples obtained during stapedectomies were negative for beta-2 transferrin, and four of five samples collected during middle ear explorations for fistula were negative for beta-2 transferrin. With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/00005537-199602000-00010</identifier><identifier>PMID: 8583846</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Honboken, NJ: Wiley-Blackwell</publisher><subject>Biological and medical sciences ; Biomarkers ; Ent. 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As expected, four CSF samples collected were positive for beta-2 transferrin; however, four known perilymph samples collected from patients undergoing cochlear implantation were negative for beta-2 transferrin, seven of nine known perilymph samples obtained during stapedectomies were negative for beta-2 transferrin, and four of five samples collected during middle ear explorations for fistula were negative for beta-2 transferrin. With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting.</description><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Ent. Stomatology</subject><subject>Humans</subject><subject>Immunoelectrophoresis - methods</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Perilymph - chemistry</subject><subject>Specimen Handling</subject><subject>Transferrin - analysis</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LBDEMhoso67r6E4QexFu1H9Np600XP1nwouBt6HRTrM6X7cxh_71V1w2EEPLmTXgQwoxeMGrUJc0hpVCEGVNSnjuSk9E9NGdSMFIYI_fRnFIuiJb87RAdpfSRFUpIOkMzLbXQRTlHTzcwWsLxGG2XPMQYOnyFm9CG0Y6h7xLuPZ4SYJuwxa4JXXC2wa2NnxCx7yMeIIZm0w7vx-jA2ybBybYu0Ovd7cvygaye7x-X1yviuC5G4jlQnp_0RkCpnCyhLKjiljtjGBRc1wxYKbWsnWdaGVHTmgrD5NozWWojFuj8z3eI_dcEaazakBw0je2gn1KllNGKMZ2F-k_oYp9SBF8NMeTPNxWj1Q_G6h9jtcNY_WLMq6fbG1Pdwnq3uOWW52fbuU2Zh8_0XEg7Gc92hdLiG0XleEQ</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>LEVENSON, M. J</creator><creator>DESLOGE, R. B</creator><creator>PARISIER, S. 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Stomatology</topic><topic>Humans</topic><topic>Immunoelectrophoresis - methods</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Perilymph - chemistry</topic><topic>Specimen Handling</topic><topic>Transferrin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEVENSON, M. J</creatorcontrib><creatorcontrib>DESLOGE, R. B</creatorcontrib><creatorcontrib>PARISIER, S. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beta-2 transferrin : limitations of use as a clinical marker for perilymph</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>106</volume><issue>2</issue><spage>159</spage><epage>161</epage><pages>159-161</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Beta-2 transferrin is a protein marker that can be used in the clinical setting to reliably identify the presence of cerebrospinal fluid (CSF). Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph. This study investigates the use of a beta-2 transferrin assay as a method to identify the presence of perilymph. Twenty-two patients were enrolled in the study. Fluid samples were obtained intraoperatively and tested for the presence of beta-2 transferrin. As expected, four CSF samples collected were positive for beta-2 transferrin; however, four known perilymph samples collected from patients undergoing cochlear implantation were negative for beta-2 transferrin, seven of nine known perilymph samples obtained during stapedectomies were negative for beta-2 transferrin, and four of five samples collected during middle ear explorations for fistula were negative for beta-2 transferrin. With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting.</abstract><cop>Honboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>8583846</pmid><doi>10.1097/00005537-199602000-00010</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 1996-02, Vol.106 (2), p.159-161 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77987118 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Biomarkers Ent. Stomatology Humans Immunoelectrophoresis - methods Investigative techniques, diagnostic techniques (general aspects) Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Perilymph - chemistry Specimen Handling Transferrin - analysis |
| title | Beta-2 transferrin : limitations of use as a clinical marker for perilymph |
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