Arm span as measurement of response to growth hormone (GH) treatment in a group of children with meningomyelocele and GH deficiency
Children with meningomyelocele (MMC) frequently have impaired linear growth. A number have associated structural brain defects with resultant GH deficiency (GHD). Reproducible measurements of height or length in MMC patients are often hampered by lower limb contractures, spasticity, and scoliosis. A...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 1996-04, Vol.81 (4), p.1654-1656 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | SATIN-SMITH, M. S KATZ, L. L THORNTON, P GRUCCIO, D MOSHANG, T. JR |
| description | Children with meningomyelocele (MMC) frequently have impaired linear growth. A number have associated structural brain defects with resultant GH deficiency (GHD). Reproducible measurements of height or length in MMC patients are often hampered by lower limb contractures, spasticity, and scoliosis. Arm span has been proposed as a more reproducible measure of linear growth. Five MMC children documented to have GHD were treated with recombinant human GH (hGH) for 1-3 yr. Their height, arm span, and growth velocity were compared with 32 children with idiopathic GHD treated similarly with hGH. These measures are compared with normal children by being expressed as standard deviation scores. The results of this study indicate that arm span measurements in GHD MMC patients are almost identical to height measurements in idiopathic GHD patients both before and during hGH therapy. The physical condition of children with MMC makes reproducible longitudinal height measurements difficult. Routine determinations of arm span measurements for children with MMC will assist in recognizing growth failure as well as monitoring treatment results. |
| doi_str_mv | 10.1210/jc.81.4.1654 |
| format | Article |
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S ; KATZ, L. L ; THORNTON, P ; GRUCCIO, D ; MOSHANG, T. JR</creator><creatorcontrib>SATIN-SMITH, M. S ; KATZ, L. L ; THORNTON, P ; GRUCCIO, D ; MOSHANG, T. JR</creatorcontrib><description>Children with meningomyelocele (MMC) frequently have impaired linear growth. A number have associated structural brain defects with resultant GH deficiency (GHD). Reproducible measurements of height or length in MMC patients are often hampered by lower limb contractures, spasticity, and scoliosis. Arm span has been proposed as a more reproducible measure of linear growth. Five MMC children documented to have GHD were treated with recombinant human GH (hGH) for 1-3 yr. Their height, arm span, and growth velocity were compared with 32 children with idiopathic GHD treated similarly with hGH. These measures are compared with normal children by being expressed as standard deviation scores. The results of this study indicate that arm span measurements in GHD MMC patients are almost identical to height measurements in idiopathic GHD patients both before and during hGH therapy. The physical condition of children with MMC makes reproducible longitudinal height measurements difficult. Routine determinations of arm span measurements for children with MMC will assist in recognizing growth failure as well as monitoring treatment results.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.81.4.1654</identifier><identifier>PMID: 8636383</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adolescent ; Anthropometry - methods ; Arm ; Biological and medical sciences ; Biomarkers - blood ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Growth - drug effects ; Growth - physiology ; Growth Hormone - blood ; Growth Hormone - deficiency ; Growth Hormone - therapeutic use ; Humans ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor I - analysis ; Longitudinal Studies ; Male ; Malformations of the nervous system ; Medical sciences ; Meningomyelocele - complications ; Meningomyelocele - drug therapy ; Meningomyelocele - physiopathology ; Neurology ; Recombinant Proteins - therapeutic use ; Reproducibility of Results</subject><ispartof>The journal of clinical endocrinology and metabolism, 1996-04, Vol.81 (4), p.1654-1656</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c315t-7ea4c04b6b0772736186a34a7d530f6d3ea5fbaeee6ec76870ed8f94fc5f4e8a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3049622$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8636383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SATIN-SMITH, M. S</creatorcontrib><creatorcontrib>KATZ, L. L</creatorcontrib><creatorcontrib>THORNTON, P</creatorcontrib><creatorcontrib>GRUCCIO, D</creatorcontrib><creatorcontrib>MOSHANG, T. JR</creatorcontrib><title>Arm span as measurement of response to growth hormone (GH) treatment in a group of children with meningomyelocele and GH deficiency</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Children with meningomyelocele (MMC) frequently have impaired linear growth. A number have associated structural brain defects with resultant GH deficiency (GHD). Reproducible measurements of height or length in MMC patients are often hampered by lower limb contractures, spasticity, and scoliosis. Arm span has been proposed as a more reproducible measure of linear growth. Five MMC children documented to have GHD were treated with recombinant human GH (hGH) for 1-3 yr. Their height, arm span, and growth velocity were compared with 32 children with idiopathic GHD treated similarly with hGH. These measures are compared with normal children by being expressed as standard deviation scores. The results of this study indicate that arm span measurements in GHD MMC patients are almost identical to height measurements in idiopathic GHD patients both before and during hGH therapy. The physical condition of children with MMC makes reproducible longitudinal height measurements difficult. Routine determinations of arm span measurements for children with MMC will assist in recognizing growth failure as well as monitoring treatment results.</description><subject>Adolescent</subject><subject>Anthropometry - methods</subject><subject>Arm</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Growth - drug effects</subject><subject>Growth - physiology</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - deficiency</subject><subject>Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Malformations of the nervous system</subject><subject>Medical sciences</subject><subject>Meningomyelocele - complications</subject><subject>Meningomyelocele - drug therapy</subject><subject>Meningomyelocele - physiopathology</subject><subject>Neurology</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Reproducibility of Results</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MFrFDEUBvAglrpWb16FHEQUOmsyySSZYym6KxS8tOAtvM28dLPMJGMyQ9mz_7izdunpHd7vezw-Qj5wtuY1Z98Obm34Wq65auQrsuKtbCrNW_2arBiredXq-vcb8raUA2NcykZckkujhBJGrMjfmzzQMkKkUOiAUOaMA8aJJk8zljHFgnRK9DGnp2lP9ykPKSL9stl-pVNGmP7jsMRPZB5PObcPfZcx0qewRBYQ4mMajtgnhz1SiB3dbGmHPriA0R3fkQsPfcH353lFHn58v7_dVne_Nj9vb-4qJ3gzVRpBOiZ3ase0rrVQ3CgQEnTXCOZVJxAavwNEVOi0MpphZ3wrvWu8RAPiinx-vjvm9GfGMtkhlOWlHiKmuVitW6OM4gu8foYup1IyejvmMEA-Ws7sqXN7cNZwK-2p84V_PN-ddwN2L_hc8rL_dN5DcdD7DNGF8sIEk62qa_EPfgmLbQ</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>SATIN-SMITH, M. S</creator><creator>KATZ, L. L</creator><creator>THORNTON, P</creator><creator>GRUCCIO, D</creator><creator>MOSHANG, T. JR</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Arm span as measurement of response to growth hormone (GH) treatment in a group of children with meningomyelocele and GH deficiency</title><author>SATIN-SMITH, M. S ; KATZ, L. L ; THORNTON, P ; GRUCCIO, D ; MOSHANG, T. JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-7ea4c04b6b0772736186a34a7d530f6d3ea5fbaeee6ec76870ed8f94fc5f4e8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Anthropometry - methods</topic><topic>Arm</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Growth - drug effects</topic><topic>Growth - physiology</topic><topic>Growth Hormone - blood</topic><topic>Growth Hormone - deficiency</topic><topic>Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Malformations of the nervous system</topic><topic>Medical sciences</topic><topic>Meningomyelocele - complications</topic><topic>Meningomyelocele - drug therapy</topic><topic>Meningomyelocele - physiopathology</topic><topic>Neurology</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SATIN-SMITH, M. S</creatorcontrib><creatorcontrib>KATZ, L. L</creatorcontrib><creatorcontrib>THORNTON, P</creatorcontrib><creatorcontrib>GRUCCIO, D</creatorcontrib><creatorcontrib>MOSHANG, T. JR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SATIN-SMITH, M. S</au><au>KATZ, L. L</au><au>THORNTON, P</au><au>GRUCCIO, D</au><au>MOSHANG, T. JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arm span as measurement of response to growth hormone (GH) treatment in a group of children with meningomyelocele and GH deficiency</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>81</volume><issue>4</issue><spage>1654</spage><epage>1656</epage><pages>1654-1656</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>Children with meningomyelocele (MMC) frequently have impaired linear growth. A number have associated structural brain defects with resultant GH deficiency (GHD). Reproducible measurements of height or length in MMC patients are often hampered by lower limb contractures, spasticity, and scoliosis. Arm span has been proposed as a more reproducible measure of linear growth. Five MMC children documented to have GHD were treated with recombinant human GH (hGH) for 1-3 yr. Their height, arm span, and growth velocity were compared with 32 children with idiopathic GHD treated similarly with hGH. These measures are compared with normal children by being expressed as standard deviation scores. The results of this study indicate that arm span measurements in GHD MMC patients are almost identical to height measurements in idiopathic GHD patients both before and during hGH therapy. The physical condition of children with MMC makes reproducible longitudinal height measurements difficult. Routine determinations of arm span measurements for children with MMC will assist in recognizing growth failure as well as monitoring treatment results.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>8636383</pmid><doi>10.1210/jc.81.4.1654</doi><tpages>3</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Anthropometry - methods Arm Biological and medical sciences Biomarkers - blood Child Child, Preschool Female Follow-Up Studies Growth - drug effects Growth - physiology Growth Hormone - blood Growth Hormone - deficiency Growth Hormone - therapeutic use Humans Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - analysis Longitudinal Studies Male Malformations of the nervous system Medical sciences Meningomyelocele - complications Meningomyelocele - drug therapy Meningomyelocele - physiopathology Neurology Recombinant Proteins - therapeutic use Reproducibility of Results |
| title | Arm span as measurement of response to growth hormone (GH) treatment in a group of children with meningomyelocele and GH deficiency |
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