Antibiotics A21459 A and B, New Inhibitors of Bacterial Protein Synthesis: I. Taxonomy, Isolation and Characterization

Antibiotics A21459 A and B, New Inhibitors of Bacterial Protein Synthesis: I. Taxonomy, Isolation and Characterization

Novel cyclic peptide antibiotics A21459 A and B are produced by a member of the genus Actinoplanes sp. These antibiotics inhibit bacterial protein synthesis and have selective antimicrobial activity against clostridia, mycoplasma and some Gram-negative bacteria.

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Veröffentlicht in:Journal of antibiotics 1996/02/25, Vol.49(2), pp.145-149
Hauptverfasser: SELVA, E., GASTALDO, L., SADDLER, G. S., TOPPO, G., FERRARI, P., CARNITI, G., GOLDSTEIN, B. P.
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetaceae - classification
Actinomycetaceae - metabolism
Actinoplanes
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - biosynthesis
Biological and medical sciences
Fermentation
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Microbiology
Molecular Structure
Peptides, Cyclic - chemistry
Peptides, Cyclic - pharmacology
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Zusammenfassung:Novel cyclic peptide antibiotics A21459 A and B are produced by a member of the genus Actinoplanes sp. These antibiotics inhibit bacterial protein synthesis and have selective antimicrobial activity against clostridia, mycoplasma and some Gram-negative bacteria.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.49.145