High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: Implications for colon cancer screening
BACKGROUND & AIMS: A visual, nonbiopsy technique that could reliably determine the histology of diminutive colorectal polyps could greatly reduce the cost of colon cancer screening. This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1996-04, Vol.110 (4), p.1253-1258 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Axelrad, AM Fleischer, DE Geller, AJ Nguyen, CC Lewis, JH Al-Kawas, FH Avigan, MI Montgomery, EA Benjamin, SB |
| description | BACKGROUND & AIMS: A visual, nonbiopsy technique that could reliably determine the histology of diminutive colorectal polyps could greatly reduce the cost of colon cancer screening. This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine dye to diagnosis diminutive colorectal polyps. METHODS: Colonoscopy using a Fujinon EC-400 HM/HL was performed in 36 patients with polyps |
| doi_str_mv | 10.1053/gast.1996.v110.pm8613016 |
| format | Article |
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This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine dye to diagnosis diminutive colorectal polyps. METHODS: Colonoscopy using a Fujinon EC-400 HM/HL was performed in 36 patients with polyps <10mm in diameter. Polyps from the first 12 patients (phase 1) were sprayed with 10 mL of 0.2% indigo carmine dye, and a biopsy was performed or a specimen removed and submitted for histological analysis. The morphological data were used to predict polyp histology in the subsequent 24 patients (phase 2). RESULTS: Hyperplastic polyps had a characteristic surface "pit pattern" of orderly arranged "dots" that resembled the surrounding, nonpolypoid mucosa. Adenomatous polyps had surface "grooves" or "sulci." Sensitivity and specificity of our techniques in distinguishing adenomatous from nonadenomatous colorectal polyps were 93% and 95% respectively. CONCLUSIONS: High-resolution chromoendoscopy provides morphological detail of diminutive colorectal polyps that correlates well with polyp histology. If incorporated into colon cancer screening, these techniques may limit the need for biopsy and/or subsequent colonoscopy and ultimately decrease costs. (Gastroenterology 1996 Apr;110(4):1253-8)</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1053/gast.1996.v110.pm8613016</identifier><identifier>PMID: 8613016</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biopsy ; Colon - pathology ; Colonic Neoplasms - prevention & control ; Colonic Polyps - diagnosis ; Colonic Polyps - pathology ; Colonoscopy - economics ; Colonoscopy - methods ; Coloring Agents ; Costs and Cost Analysis ; Digestive system. Abdomen ; Endoscopy ; Humans ; Indigo Carmine ; Investigative techniques, diagnostic techniques (general aspects) ; Mass Screening - economics ; Mass Screening - methods ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Sensitivity and Specificity</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1996-04, Vol.110 (4), p.1253-1258</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-2223518f0502d0470d365c4877e5f377305802b2e314f2317b5ee4e771c4c5a93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/gast.1996.v110.pm8613016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3041546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8613016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Axelrad, AM</creatorcontrib><creatorcontrib>Fleischer, DE</creatorcontrib><creatorcontrib>Geller, AJ</creatorcontrib><creatorcontrib>Nguyen, CC</creatorcontrib><creatorcontrib>Lewis, JH</creatorcontrib><creatorcontrib>Al-Kawas, FH</creatorcontrib><creatorcontrib>Avigan, MI</creatorcontrib><creatorcontrib>Montgomery, EA</creatorcontrib><creatorcontrib>Benjamin, SB</creatorcontrib><title>High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: Implications for colon cancer screening</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>BACKGROUND & AIMS: A visual, nonbiopsy technique that could reliably determine the histology of diminutive colorectal polyps could greatly reduce the cost of colon cancer screening. This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine dye to diagnosis diminutive colorectal polyps. METHODS: Colonoscopy using a Fujinon EC-400 HM/HL was performed in 36 patients with polyps <10mm in diameter. Polyps from the first 12 patients (phase 1) were sprayed with 10 mL of 0.2% indigo carmine dye, and a biopsy was performed or a specimen removed and submitted for histological analysis. The morphological data were used to predict polyp histology in the subsequent 24 patients (phase 2). RESULTS: Hyperplastic polyps had a characteristic surface "pit pattern" of orderly arranged "dots" that resembled the surrounding, nonpolypoid mucosa. Adenomatous polyps had surface "grooves" or "sulci." Sensitivity and specificity of our techniques in distinguishing adenomatous from nonadenomatous colorectal polyps were 93% and 95% respectively. CONCLUSIONS: High-resolution chromoendoscopy provides morphological detail of diminutive colorectal polyps that correlates well with polyp histology. If incorporated into colon cancer screening, these techniques may limit the need for biopsy and/or subsequent colonoscopy and ultimately decrease costs. (Gastroenterology 1996 Apr;110(4):1253-8)</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Colon - pathology</subject><subject>Colonic Neoplasms - prevention & control</subject><subject>Colonic Polyps - diagnosis</subject><subject>Colonic Polyps - pathology</subject><subject>Colonoscopy - economics</subject><subject>Colonoscopy - methods</subject><subject>Coloring Agents</subject><subject>Costs and Cost Analysis</subject><subject>Digestive system. Abdomen</subject><subject>Endoscopy</subject><subject>Humans</subject><subject>Indigo Carmine</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Mass Screening - economics</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Sensitivity and Specificity</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGO0zAQhi0EWroLj4DkA-KWMo7j2OEGK2BXWokLnC3XmbRGSRw8SaW-PQ6tynFPI_v__rH1McYFbAUo-XHvaN6Kpqm3R5HvpsHUQoKoX7CNUKUpAET5km3yqAsFRr1mt0S_AaCRRtywmwu-YctD2B-KhBT7ZQ5x5P6Q4hBxbCP5OJ14FxOfD8jb4PZjpEA8dvkwhDHzR-Q-9rk1xf400Sf-OEx98G7dRP-q59i70WPi5BPiGMb9G_aqcz3h28u8Y7--ff15_1A8_fj-eP_5qfBKVHNRlqVUwnSgoGyh0tDKWvnKaI2qk1pLUAbKXYlSVF0phd4pxAq1Fr7yyjXyjn04751S_LMgzXYI5LHv3YhxIat1Y1QDkEFzBn2KRAk7O6UwuHSyAuxq3K7G7Wrcrsbt1Xiuvru8sewGbK_F__n7S-7Iu75L2UWgKyahEqpasS9nDLOPY8BkyQfM2tqQ0M-2jeH5v_wFbJGi1g</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Axelrad, AM</creator><creator>Fleischer, DE</creator><creator>Geller, AJ</creator><creator>Nguyen, CC</creator><creator>Lewis, JH</creator><creator>Al-Kawas, FH</creator><creator>Avigan, MI</creator><creator>Montgomery, EA</creator><creator>Benjamin, SB</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: Implications for colon cancer screening</title><author>Axelrad, AM ; Fleischer, DE ; Geller, AJ ; Nguyen, CC ; Lewis, JH ; Al-Kawas, FH ; Avigan, MI ; Montgomery, EA ; Benjamin, SB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-2223518f0502d0470d365c4877e5f377305802b2e314f2317b5ee4e771c4c5a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Colon - pathology</topic><topic>Colonic Neoplasms - prevention & control</topic><topic>Colonic Polyps - diagnosis</topic><topic>Colonic Polyps - pathology</topic><topic>Colonoscopy - economics</topic><topic>Colonoscopy - methods</topic><topic>Coloring Agents</topic><topic>Costs and Cost Analysis</topic><topic>Digestive system. Abdomen</topic><topic>Endoscopy</topic><topic>Humans</topic><topic>Indigo Carmine</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Mass Screening - economics</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Axelrad, AM</creatorcontrib><creatorcontrib>Fleischer, DE</creatorcontrib><creatorcontrib>Geller, AJ</creatorcontrib><creatorcontrib>Nguyen, CC</creatorcontrib><creatorcontrib>Lewis, JH</creatorcontrib><creatorcontrib>Al-Kawas, FH</creatorcontrib><creatorcontrib>Avigan, MI</creatorcontrib><creatorcontrib>Montgomery, EA</creatorcontrib><creatorcontrib>Benjamin, SB</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Axelrad, AM</au><au>Fleischer, DE</au><au>Geller, AJ</au><au>Nguyen, CC</au><au>Lewis, JH</au><au>Al-Kawas, FH</au><au>Avigan, MI</au><au>Montgomery, EA</au><au>Benjamin, SB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: Implications for colon cancer screening</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>110</volume><issue>4</issue><spage>1253</spage><epage>1258</epage><pages>1253-1258</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>BACKGROUND & AIMS: A visual, nonbiopsy technique that could reliably determine the histology of diminutive colorectal polyps could greatly reduce the cost of colon cancer screening. This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine dye to diagnosis diminutive colorectal polyps. METHODS: Colonoscopy using a Fujinon EC-400 HM/HL was performed in 36 patients with polyps <10mm in diameter. Polyps from the first 12 patients (phase 1) were sprayed with 10 mL of 0.2% indigo carmine dye, and a biopsy was performed or a specimen removed and submitted for histological analysis. The morphological data were used to predict polyp histology in the subsequent 24 patients (phase 2). RESULTS: Hyperplastic polyps had a characteristic surface "pit pattern" of orderly arranged "dots" that resembled the surrounding, nonpolypoid mucosa. Adenomatous polyps had surface "grooves" or "sulci." Sensitivity and specificity of our techniques in distinguishing adenomatous from nonadenomatous colorectal polyps were 93% and 95% respectively. CONCLUSIONS: High-resolution chromoendoscopy provides morphological detail of diminutive colorectal polyps that correlates well with polyp histology. If incorporated into colon cancer screening, these techniques may limit the need for biopsy and/or subsequent colonoscopy and ultimately decrease costs. (Gastroenterology 1996 Apr;110(4):1253-8)</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8613016</pmid><doi>10.1053/gast.1996.v110.pm8613016</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0016-5085 |
| ispartof | Gastroenterology (New York, N.Y. 1943), 1996-04, Vol.110 (4), p.1253-1258 |
| issn | 0016-5085 1528-0012 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Biopsy Colon - pathology Colonic Neoplasms - prevention & control Colonic Polyps - diagnosis Colonic Polyps - pathology Colonoscopy - economics Colonoscopy - methods Coloring Agents Costs and Cost Analysis Digestive system. Abdomen Endoscopy Humans Indigo Carmine Investigative techniques, diagnostic techniques (general aspects) Mass Screening - economics Mass Screening - methods Medical sciences Middle Aged Predictive Value of Tests Sensitivity and Specificity |
| title | High-resolution chromoendoscopy for the diagnosis of diminutive colon polyps: Implications for colon cancer screening |
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