Suppression of Endothelin-1 Production in Cultured Human Umbilical Vein Endothelial Cells by Heparin Fractions Separated by Strong Anion Exchange Chromatography

Heparin has been shown to lower the production/secretion of the vasoconstrictive peptide endothelin-1. Endothelin-1 production is stimulated by thrombin, and it has been proposed that heparin binds to the anion-binding exosite of thrombin, preventing it from stimulating endothelin-1 production. To f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of biochemistry and biophysics 1996-03, Vol.327 (2), p.234-238
Hauptverfasser:	Reantragoon, Somsak, Arrigo, Lisa M., Dweck, Harry S., Rosenfeld, Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - isolation & purification Anticoagulants - pharmacology Cells, Cultured Chromatography, Gel Chromatography, Ion Exchange Culture Media, Conditioned endothelial cell regulation endothelin-1 Endothelins - antagonists & inhibitors Endothelins - biosynthesis Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism functional thrombin receptor Heparin - isolation & purification Heparin - pharmacology Heparin anionic charge heparin anticoagulant activity human umbilical vein endothelial cells (HUVEC) Humans Kinetics Lithium Chloride - pharmacology Molecular Weight Potassium Chloride - pharmacology Sodium Chloride - pharmacology thrombin Umbilical Veins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!