Cloning and characterization of the thyroid iodide transporter
IODIDE (I - ) is an essential constituent of the thyroid hormones T 3 and T 4 , and is accumulated by the thyroid. The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na + /I - symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and...
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| Veröffentlicht in: | Nature (London) 1996-02, Vol.379 (6564), p.458-460 |
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| creator | Dai, Ge Levy, Orlie Carrasco, Nancy |
| description | IODIDE (I
-
) is an essential constituent of the thyroid hormones T
3
and T
4
, and is accumulated by the thyroid. The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na
+
/I
-
symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and treatment of thyroid disorders. Although several other important thyroid proteins involved in hormogenesis have been characterized, the Na
+
/I
-
symporter has not. Here we report the isolation of a complementary DNA clone that encodes this symporter, as a result of functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5) in
Xenopus laevis
oocytes. Oocyte microinjection of an RNA transcript made
in vitro
from this cDNA clone elicited a more than 700-fold increase in perchlorate-sensitive Na
+
/I
-
symport activity over background. To our knowledge, this is the first iodide-transporting molecule to have its cDNA cloned, providing a missing link in the thyroid hormone biosynthetic pathway. |
| doi_str_mv | 10.1038/379458a0 |
| format | Article |
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-
) is an essential constituent of the thyroid hormones T
3
and T
4
, and is accumulated by the thyroid. The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na
+
/I
-
symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and treatment of thyroid disorders. Although several other important thyroid proteins involved in hormogenesis have been characterized, the Na
+
/I
-
symporter has not. Here we report the isolation of a complementary DNA clone that encodes this symporter, as a result of functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5) in
Xenopus laevis
oocytes. Oocyte microinjection of an RNA transcript made
in vitro
from this cDNA clone elicited a more than 700-fold increase in perchlorate-sensitive Na
+
/I
-
symport activity over background. To our knowledge, this is the first iodide-transporting molecule to have its cDNA cloned, providing a missing link in the thyroid hormone biosynthetic pathway.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/379458a0</identifier><identifier>PMID: 8559252</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Analytical, structural and metabolic biochemistry ; Animals ; Binding and carrier proteins ; Biological and medical sciences ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell Line ; Cloning ; Cloning, Molecular ; Deoxyribonucleic acid ; DNA ; DNA, Complementary ; Fundamental and applied biological sciences. Psychology ; Hormones ; Humanities and Social Sciences ; Iodides ; letter ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Molecular Sequence Data ; multidisciplinary ; Perchlorate ; Proteins ; Science ; Science (multidisciplinary) ; Symporters ; Thyroid ; Thyroid gland ; Thyroid Gland - metabolism ; Xenopus laevis</subject><ispartof>Nature (London), 1996-02, Vol.379 (6564), p.458-460</ispartof><rights>Springer Nature Limited 1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Feb 1, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-b4f356638f68b61da489bc329a05594e45f39b4d1c2810b26ae387060d85fdd93</citedby><cites>FETCH-LOGICAL-c496t-b4f356638f68b61da489bc329a05594e45f39b4d1c2810b26ae387060d85fdd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/379458a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/379458a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2970446$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8559252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Ge</creatorcontrib><creatorcontrib>Levy, Orlie</creatorcontrib><creatorcontrib>Carrasco, Nancy</creatorcontrib><title>Cloning and characterization of the thyroid iodide transporter</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IODIDE (I
-
) is an essential constituent of the thyroid hormones T
3
and T
4
, and is accumulated by the thyroid. The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na
+
/I
-
symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and treatment of thyroid disorders. Although several other important thyroid proteins involved in hormogenesis have been characterized, the Na
+
/I
-
symporter has not. Here we report the isolation of a complementary DNA clone that encodes this symporter, as a result of functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5) in
Xenopus laevis
oocytes. Oocyte microinjection of an RNA transcript made
in vitro
from this cDNA clone elicited a more than 700-fold increase in perchlorate-sensitive Na
+
/I
-
symport activity over background. To our knowledge, this is the first iodide-transporting molecule to have its cDNA cloned, providing a missing link in the thyroid hormone biosynthetic pathway.</description><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Binding and carrier proteins</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Line</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Complementary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones</subject><subject>Humanities and Social Sciences</subject><subject>Iodides</subject><subject>letter</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Perchlorate</subject><subject>Proteins</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Symporters</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - metabolism</subject><subject>Xenopus laevis</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtLAzEUhYMotT7APyAMIqKL0ZvJeyNI8QUFN7oeMklGI9NJTaYL_fWmtCrowkUI4Xycc3MPQgcYzjEQeUGEokxq2EBjTAUvKZdiE40BKlmCJHwb7aT0CgAMCzpCI8mYqlg1RpeTLvS-fy50bwvzoqM2g4v-Qw8-9EVoi-HF5fMeg7eFD9bb_Iy6T_MQM7iHtlrdJbe_vnfR08314-SunD7c3k-upqWhig9lQ1vCOCey5bLh2GoqVWNIpTTkQaijrCWqoRabSmJoKq4dkQI4WMlaaxXZRScr33kMbwuXhnrmk3Fdp3sXFqkWQkmCKfwLEpb3pfj_jljkZUmgGTz6Bb6GRezzb-sKKBUSFM_Q6QoyMaQUXVvPo5_p-F5jqJcN1V8NZfRw7bdoZs5-g-tKsn681nUyumvzso1P31ilRE5dJp6tsJSV_tnFn7H-RH4COUKilQ</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Dai, Ge</creator><creator>Levy, Orlie</creator><creator>Carrasco, Nancy</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Cloning and characterization of the thyroid iodide transporter</title><author>Dai, Ge ; Levy, Orlie ; Carrasco, Nancy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-b4f356638f68b61da489bc329a05594e45f39b4d1c2810b26ae387060d85fdd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Binding and carrier proteins</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Line</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Complementary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones</topic><topic>Humanities and Social Sciences</topic><topic>Iodides</topic><topic>letter</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Perchlorate</topic><topic>Proteins</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Symporters</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - metabolism</topic><topic>Xenopus laevis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Ge</creatorcontrib><creatorcontrib>Levy, Orlie</creatorcontrib><creatorcontrib>Carrasco, Nancy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Database (Proquest)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Ge</au><au>Levy, Orlie</au><au>Carrasco, Nancy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning and characterization of the thyroid iodide transporter</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>379</volume><issue>6564</issue><spage>458</spage><epage>460</epage><pages>458-460</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>IODIDE (I
-
) is an essential constituent of the thyroid hormones T
3
and T
4
, and is accumulated by the thyroid. The transport of iodide, the first step in thyroid hormogenesis, is catalysed by the Na
+
/I
-
symporter, an intrinsic membrane protein that is crucial for the evaluation, diagnosis and treatment of thyroid disorders. Although several other important thyroid proteins involved in hormogenesis have been characterized, the Na
+
/I
-
symporter has not. Here we report the isolation of a complementary DNA clone that encodes this symporter, as a result of functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5) in
Xenopus laevis
oocytes. Oocyte microinjection of an RNA transcript made
in vitro
from this cDNA clone elicited a more than 700-fold increase in perchlorate-sensitive Na
+
/I
-
symport activity over background. To our knowledge, this is the first iodide-transporting molecule to have its cDNA cloned, providing a missing link in the thyroid hormone biosynthetic pathway.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>8559252</pmid><doi>10.1038/379458a0</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1996-02, Vol.379 (6564), p.458-460 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77983140 |
| source | MEDLINE; Springer Nature - Connect here FIRST to enable access; SpringerLink (Online service) |
| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Binding and carrier proteins Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cloning Cloning, Molecular Deoxyribonucleic acid DNA DNA, Complementary Fundamental and applied biological sciences. Psychology Hormones Humanities and Social Sciences Iodides letter Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data multidisciplinary Perchlorate Proteins Science Science (multidisciplinary) Symporters Thyroid Thyroid gland Thyroid Gland - metabolism Xenopus laevis |
| title | Cloning and characterization of the thyroid iodide transporter |
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