Spontaneous lung metastases in a human lung tumor xenograft : a new experimental model
The cell line NIH-H460, derived from a human large-cell carcinoma of the lung, because metastatic in the lung of athymic mice after S.C. injection. Using serial S.C. passages of the lung metastasis, a cell line was selected, H460M, which was characterized by an increased metastatic potential compare...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1996, Vol.122 (3), p.154-160 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | CORTI, C PRATESI, G DE CESARE, M PELLEGRINI, R GIARDINI, R SUPINO, R ZUMINO, F |
| description | The cell line NIH-H460, derived from a human large-cell carcinoma of the lung, because metastatic in the lung of athymic mice after S.C. injection. Using serial S.C. passages of the lung metastasis, a cell line was selected, H460M, which was characterized by an increased metastatic potential compared to the parental cells after s.c. (Spontaneous metastases) or i.v. injection (experimental metastases). For the high frequency of lung metastases in the mouse and the short time required to develop metastatic foci, the H460M cells transplanted in nude mice represent a unique preclinical model for biological and therapeutic studies. The paper describes the growth and some biological properties (invasion and migration capability, membrane profile) of this experimental in vivo model. |
| doi_str_mv | 10.1007/BF01366955 |
| format | Article |
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Using serial S.C. passages of the lung metastasis, a cell line was selected, H460M, which was characterized by an increased metastatic potential compared to the parental cells after s.c. (Spontaneous metastases) or i.v. injection (experimental metastases). For the high frequency of lung metastases in the mouse and the short time required to develop metastatic foci, the H460M cells transplanted in nude mice represent a unique preclinical model for biological and therapeutic studies. The paper describes the growth and some biological properties (invasion and migration capability, membrane profile) of this experimental in vivo model.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/BF01366955</identifier><identifier>PMID: 8601563</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animal tumors. 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Using serial S.C. passages of the lung metastasis, a cell line was selected, H460M, which was characterized by an increased metastatic potential compared to the parental cells after s.c. (Spontaneous metastases) or i.v. injection (experimental metastases). For the high frequency of lung metastases in the mouse and the short time required to develop metastatic foci, the H460M cells transplanted in nude mice represent a unique preclinical model for biological and therapeutic studies. The paper describes the growth and some biological properties (invasion and migration capability, membrane profile) of this experimental in vivo model.</description><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Large Cell - pathology</subject><subject>Carcinoma, Large Cell - secondary</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Non-Small-Cell Lung - secondary</subject><subject>Cell Division - physiology</subject><subject>Cell Membrane - chemistry</subject><subject>Cell Membrane - ultrastructure</subject><subject>Cell Movement - physiology</subject><subject>Disease Models, Animal</subject><subject>Experimental respiratory system tumors</subject><subject>Humans</subject><subject>Injections, Subcutaneous</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - secondary</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Invasiveness</subject><subject>Phenotype</subject><subject>Receptors, Cell Surface - analysis</subject><subject>Transplantation, Heterologous</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo67p68S7kIB6Eaj6apPWmi6vCggc_rmU2O10rbVqbFtd_b6RlhcAQnoeXmZeQU86uOGPm-m7BuNQ6VWqPTHksRcSlVPtkyrjhkRJcH5Ij7z9Z-CsjJmSSaMaVllPy_tLUrgOHde9p2bsNrbADHx56WjgK9KOvwA2o66u6pVt09aaFvKM3ATv8prhtsC0qDEElreo1lsfkIIfS48k4Z-Rtcf86f4yWzw9P89tlZCXnXRQzBmC5thqFiZlSTOVolbIWYsBEg-Q2BQXxysRS2yQ3uUAuGIoVV4m2ckYuhtymrb969F1WFd5iWQ4XZcakiYiZDuLlINq29r7FPGvCxtD-ZJxlfyVm_yUG-WxM7VcVrnfq2Frg5yMHb6HMW3C28DtNpCbROpa_CQR4xQ</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>CORTI, C</creator><creator>PRATESI, G</creator><creator>DE CESARE, M</creator><creator>PELLEGRINI, R</creator><creator>GIARDINI, R</creator><creator>SUPINO, R</creator><creator>ZUMINO, F</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Spontaneous lung metastases in a human lung tumor xenograft : a new experimental model</title><author>CORTI, C ; PRATESI, G ; DE CESARE, M ; PELLEGRINI, R ; GIARDINI, R ; SUPINO, R ; ZUMINO, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-400aac16c6e27405505fec55cca4ae86a31c9a5a4b7436c8f7f2e120e2b1586c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animal tumors. 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| ispartof | Journal of cancer research and clinical oncology, 1996, Vol.122 (3), p.154-160 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animal tumors. Experimental tumors Animals Biological and medical sciences Carcinoma, Large Cell - pathology Carcinoma, Large Cell - secondary Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - secondary Cell Division - physiology Cell Membrane - chemistry Cell Membrane - ultrastructure Cell Movement - physiology Disease Models, Animal Experimental respiratory system tumors Humans Injections, Subcutaneous Lung Neoplasms - pathology Lung Neoplasms - secondary Medical sciences Mice Mice, Nude Neoplasm Invasiveness Phenotype Receptors, Cell Surface - analysis Transplantation, Heterologous Tumor Cells, Cultured Tumors |
| title | Spontaneous lung metastases in a human lung tumor xenograft : a new experimental model |
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