Peripheral Blood Mononuclear Cells of a Patient With Advanced Hodgkin's Lymphoma Give Rise to Permanently Growing Hodgkin-Reed Sternberg Cells

A novel Hodgkin's disease (HD) derived cell line, L1236, was established from the peripheral blood of a patient with advanced Hodgkin's disease. Analysis of immunoglobulin (Ig) gene rearrangements revealed a biallelic Ig heavy chain and a monoallelic Ig kappa light chain gene rearrangement...

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Veröffentlicht in:	Blood 1996-04, Vol.87 (8), p.3418-3428
Hauptverfasser:	Wolf, Jürgen, Kapp, Ursula, Bohlen, Heribert, Kornacker, Martin, Schoch, Claudia, Stahl, Bettina, Mücke, Susanne, Kalle, Christof von, Fonatsch, Christa, Schaefer, Hans-Eckart, Hansmann, Martin-Leo, Diehl, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antigens, Differentiation, B-Lymphocyte - analysis Antigens, Neoplasm - analysis B-Lymphocytes - pathology Biological and medical sciences Biomarkers, Tumor - analysis Bone Marrow - pathology Cytokines - metabolism Fatal Outcome Gene Rearrangement, B-Lymphocyte, Heavy Chain Gene Rearrangement, B-Lymphocyte, Light Chain Hematologic and hematopoietic diseases Hodgkin Disease - blood Hodgkin Disease - genetics Hodgkin Disease - pathology Humans Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Mice Mice, SCID Neoplasm Proteins - analysis Neoplasm Transplantation Neoplastic Cells, Circulating Reed-Sternberg Cells - immunology Reed-Sternberg Cells - metabolism Reed-Sternberg Cells - pathology Tumor Cells, Cultured
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