Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction
Experimental studies indicate that oxygen-free radicals contribute to ischemic myocardial damage and affect electric properties of cellular membranes. We hypothesize that an association exists between an oxygen-free radical-induced component of myocardial ischemic injury and altered electric functio...
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| Veröffentlicht in: | The American journal of cardiology 1996-02, Vol.77 (4), p.237-241 |
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| creator | Chamiec, Tomasz Herbaczyńska-Cedro, Krystyna Ceremużyński, Leszek |
| description | Experimental studies indicate that oxygen-free radicals contribute to ischemic myocardial damage and affect electric properties of cellular membranes. We hypothesize that an association exists between an oxygen-free radical-induced component of myocardial ischemic injury and altered electric function that underlies the genesis of ventricular late potentials in the course of myocardial infarction. If so, antioxidant vitamins C and E may prevent alterations in the signal-averaged electrocardiogram (SAECG). To test this hypothesis, we investigated the effect of supplementation with vitamins C and E on the indices of the SAECG in patients with acute myocardial infarction (AMI). Sixty-one patients with AMI were randomized to receive conventional treatment and vitamins C and E, each 600 mg/day, orally for 14 days (supplemented group, n = 33) or conventional treatment only (control group, n = 28). SAECG was recorded on days 1 or 2 and between days 9 and 13 (mean 10). Serum ascorbic acid, tocopherol, plasma lipid peroxides, and oxygen-free radical production by isolated leukocytes were measured on days 1 or 2 and between days 12 and 14. In the control group, SAECG showed an increase in mean QRS and low-amplitude ( |
| doi_str_mv | 10.1016/S0002-9149(97)89385-X |
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We hypothesize that an association exists between an oxygen-free radical-induced component of myocardial ischemic injury and altered electric function that underlies the genesis of ventricular late potentials in the course of myocardial infarction. If so, antioxidant vitamins C and E may prevent alterations in the signal-averaged electrocardiogram (SAECG). To test this hypothesis, we investigated the effect of supplementation with vitamins C and E on the indices of the SAECG in patients with acute myocardial infarction (AMI). Sixty-one patients with AMI were randomized to receive conventional treatment and vitamins C and E, each 600 mg/day, orally for 14 days (supplemented group, n = 33) or conventional treatment only (control group, n = 28). SAECG was recorded on days 1 or 2 and between days 9 and 13 (mean 10). Serum ascorbic acid, tocopherol, plasma lipid peroxides, and oxygen-free radical production by isolated leukocytes were measured on days 1 or 2 and between days 12 and 14. In the control group, SAECG showed an increase in mean QRS and low-amplitude (<40 μV) signal durations, from 99 ± 10 to 111 ± 13 ms (p < 0.001) and from 31 ± 8 to 38 ± 10 ms (p < 0.001), respectively, and a decrease in the root-mean-square voltage of the last 40 ms of the QRS complex, from 36 ± 25 to 21 ± 11 μV (p < 0.002). In vitamin-supplemented patients, all these indices remained unchanged. Oxygen-free radical production by isolated leukocytes was decreased compared with that in controls (p < 0.02). Supplementation was confirmed by elevation of serum ascorbic acid and tocopherol. Results support the hypothesis that in patients with AMI, oxygen-free radical-induced cellular damage contributes to alterations in electric function of the heart as seen on the SAECG.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(97)89385-X</identifier><identifier>PMID: 8607400</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Antioxidants - therapeutic use ; Ascorbic Acid - blood ; Ascorbic Acid - therapeutic use ; Biological and medical sciences ; Drug Therapy, Combination ; Electrocardiography ; Female ; Free Radicals ; General and cellular metabolism. Vitamins ; Heart attacks ; Humans ; Leukocytes - drug effects ; Leukocytes - metabolism ; Lipid Peroxides - blood ; Luminescent Measurements ; Male ; Medical research ; Medical sciences ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Myocardial Infarction - drug therapy ; Pharmacology. Drug treatments ; Reactive Oxygen Species - metabolism ; Signal Processing, Computer-Assisted ; Vitamin C ; Vitamin E ; Vitamin E - blood ; Vitamin E - therapeutic use</subject><ispartof>The American journal of cardiology, 1996-02, Vol.77 (4), p.237-241</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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We hypothesize that an association exists between an oxygen-free radical-induced component of myocardial ischemic injury and altered electric function that underlies the genesis of ventricular late potentials in the course of myocardial infarction. If so, antioxidant vitamins C and E may prevent alterations in the signal-averaged electrocardiogram (SAECG). To test this hypothesis, we investigated the effect of supplementation with vitamins C and E on the indices of the SAECG in patients with acute myocardial infarction (AMI). Sixty-one patients with AMI were randomized to receive conventional treatment and vitamins C and E, each 600 mg/day, orally for 14 days (supplemented group, n = 33) or conventional treatment only (control group, n = 28). SAECG was recorded on days 1 or 2 and between days 9 and 13 (mean 10). Serum ascorbic acid, tocopherol, plasma lipid peroxides, and oxygen-free radical production by isolated leukocytes were measured on days 1 or 2 and between days 12 and 14. In the control group, SAECG showed an increase in mean QRS and low-amplitude (<40 μV) signal durations, from 99 ± 10 to 111 ± 13 ms (p < 0.001) and from 31 ± 8 to 38 ± 10 ms (p < 0.001), respectively, and a decrease in the root-mean-square voltage of the last 40 ms of the QRS complex, from 36 ± 25 to 21 ± 11 μV (p < 0.002). In vitamin-supplemented patients, all these indices remained unchanged. Oxygen-free radical production by isolated leukocytes was decreased compared with that in controls (p < 0.02). Supplementation was confirmed by elevation of serum ascorbic acid and tocopherol. Results support the hypothesis that in patients with AMI, oxygen-free radical-induced cellular damage contributes to alterations in electric function of the heart as seen on the SAECG.</description><subject>Adult</subject><subject>Aged</subject><subject>Antioxidants - therapeutic use</subject><subject>Ascorbic Acid - blood</subject><subject>Ascorbic Acid - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Free Radicals</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - metabolism</subject><subject>Lipid Peroxides - blood</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><subject>Vitamin E - therapeutic use</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYModbv6EQpBpOjD1GQmf59Elq0KhT6o0LdwN8ksqTNJTWaW9tub7S774IsvueTc3z0k5yJ0QckVJVR8-kEIaRtNmf6g5UelO8WbuxdoQZXUDdW0e4kWJ-Q1Oi_lvl4p5eIMnSlBJCNkgX6v-97bqeDUY4hTSI_B1Yp3YYIxxIJXVXZ4jVPEJWwjDA3sfIatd9gPdTInC9mFtM0w4hAx2HnyeHw6yDBUrYdsq3N8g171MBT_9liX6Nf1-ufqW3Nz-_X76stNYxkVU8OVY1QDByo8IXajJd94pToLpCMOOGNSWleJ1ltGAHrWgq4CF0po7Ui3RJcH34ec_sy-TGYMxfphgOjTXIyUWlGuRAXf_QPepznXPxbTdqQTYn8uET9ANqdSsu_NQw4j5CdDidlvwjxvwuxjNlqa502Yuzp3cTSfN6N3p6lj9LX__tiHYmHoM0QbyglrtW4l0xX7fMB8TWwXfDbFBh-tdyHX-I1L4T8P-QsY76W8</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Chamiec, Tomasz</creator><creator>Herbaczyńska-Cedro, Krystyna</creator><creator>Ceremużyński, Leszek</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction</title><author>Chamiec, Tomasz ; Herbaczyńska-Cedro, Krystyna ; Ceremużyński, Leszek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-58d419a5a16e00cb975be883ca030da54477cd19a2ec40aaf42a9cd1568699d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antioxidants - therapeutic use</topic><topic>Ascorbic Acid - blood</topic><topic>Ascorbic Acid - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Drug Therapy, Combination</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Free Radicals</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - metabolism</topic><topic>Lipid Peroxides - blood</topic><topic>Luminescent Measurements</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><topic>Vitamin E - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chamiec, Tomasz</creatorcontrib><creatorcontrib>Herbaczyńska-Cedro, Krystyna</creatorcontrib><creatorcontrib>Ceremużyński, Leszek</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chamiec, Tomasz</au><au>Herbaczyńska-Cedro, Krystyna</au><au>Ceremużyński, Leszek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>77</volume><issue>4</issue><spage>237</spage><epage>241</epage><pages>237-241</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Experimental studies indicate that oxygen-free radicals contribute to ischemic myocardial damage and affect electric properties of cellular membranes. We hypothesize that an association exists between an oxygen-free radical-induced component of myocardial ischemic injury and altered electric function that underlies the genesis of ventricular late potentials in the course of myocardial infarction. If so, antioxidant vitamins C and E may prevent alterations in the signal-averaged electrocardiogram (SAECG). To test this hypothesis, we investigated the effect of supplementation with vitamins C and E on the indices of the SAECG in patients with acute myocardial infarction (AMI). Sixty-one patients with AMI were randomized to receive conventional treatment and vitamins C and E, each 600 mg/day, orally for 14 days (supplemented group, n = 33) or conventional treatment only (control group, n = 28). SAECG was recorded on days 1 or 2 and between days 9 and 13 (mean 10). Serum ascorbic acid, tocopherol, plasma lipid peroxides, and oxygen-free radical production by isolated leukocytes were measured on days 1 or 2 and between days 12 and 14. In the control group, SAECG showed an increase in mean QRS and low-amplitude (<40 μV) signal durations, from 99 ± 10 to 111 ± 13 ms (p < 0.001) and from 31 ± 8 to 38 ± 10 ms (p < 0.001), respectively, and a decrease in the root-mean-square voltage of the last 40 ms of the QRS complex, from 36 ± 25 to 21 ± 11 μV (p < 0.002). In vitamin-supplemented patients, all these indices remained unchanged. Oxygen-free radical production by isolated leukocytes was decreased compared with that in controls (p < 0.02). Supplementation was confirmed by elevation of serum ascorbic acid and tocopherol. Results support the hypothesis that in patients with AMI, oxygen-free radical-induced cellular damage contributes to alterations in electric function of the heart as seen on the SAECG.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8607400</pmid><doi>10.1016/S0002-9149(97)89385-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1996-02, Vol.77 (4), p.237-241 |
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| subjects | Adult Aged Antioxidants - therapeutic use Ascorbic Acid - blood Ascorbic Acid - therapeutic use Biological and medical sciences Drug Therapy, Combination Electrocardiography Female Free Radicals General and cellular metabolism. Vitamins Heart attacks Humans Leukocytes - drug effects Leukocytes - metabolism Lipid Peroxides - blood Luminescent Measurements Male Medical research Medical sciences Middle Aged Myocardial Infarction - blood Myocardial Infarction - diagnosis Myocardial Infarction - drug therapy Pharmacology. Drug treatments Reactive Oxygen Species - metabolism Signal Processing, Computer-Assisted Vitamin C Vitamin E Vitamin E - blood Vitamin E - therapeutic use |
| title | Effects of antioxidant vitamins C and E on signal-averaged electrocardiogram in acute myocardial infarction |
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