Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-c...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-01, Vol.271 (5248), p.518-520 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Acton, Susan Rigotti, Attilio Landschulz, Katherine T. Xu, Shangzhe Hobbs, Helen H. Krieger, Monty |
| description | High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway. |
| doi_str_mv | 10.1126/science.271.5248.518 |
| format | Article |
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SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.271.5248.518</identifier><identifier>PMID: 8560269</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adrenal Glands - metabolism ; Animals ; Biological and medical sciences ; Carrier Proteins ; CD36 Antigens - genetics ; CD36 Antigens - metabolism ; Cell lines ; Cell receptors ; Cell regulation ; Cell structures and functions ; Cellular biology ; Cellular control mechanisms ; CHO Cells ; Cholesterol ; Cholesterol - metabolism ; Cholesterol Esters - metabolism ; Cholesterols ; COS cells ; Cricetinae ; Death ; Female ; Fluorescent Dyes - metabolism ; Fundamental and applied biological sciences. Psychology ; HDL lipoproteins ; Hepatocytes ; High density lipoproteins ; Lipids ; Lipoproteins, HDL - metabolism ; Liver ; Liver - metabolism ; Membrane Proteins ; Mice ; Miscellaneous ; Molecular and cellular biology ; Molecular Sequence Data ; Ovaries ; Ovary - metabolism ; Proteins ; Receptors ; Receptors, Immunologic ; Receptors, LDL - metabolism ; Receptors, Lipoprotein - metabolism ; Receptors, Scavenger ; RNA-Binding Proteins ; Scavenger Receptors, Class B ; Thiazines - metabolism ; Transfection</subject><ispartof>Science (American Association for the Advancement of Science), 1996-01, Vol.271 (5248), p.518-520</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 26, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c750t-d72dd627c0365b546a47837b81c1217b47d4fa35e8d348eaa2cd150373baed463</citedby><cites>FETCH-LOGICAL-c750t-d72dd627c0365b546a47837b81c1217b47d4fa35e8d348eaa2cd150373baed463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2890159$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2890159$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2966322$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8560269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Acton, Susan</creatorcontrib><creatorcontrib>Rigotti, Attilio</creatorcontrib><creatorcontrib>Landschulz, Katherine T.</creatorcontrib><creatorcontrib>Xu, Shangzhe</creatorcontrib><creatorcontrib>Hobbs, Helen H.</creatorcontrib><creatorcontrib>Krieger, Monty</creatorcontrib><title>Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.</description><subject>Adrenal Glands - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins</subject><subject>CD36 Antigens - genetics</subject><subject>CD36 Antigens - metabolism</subject><subject>Cell lines</subject><subject>Cell receptors</subject><subject>Cell regulation</subject><subject>Cell structures and functions</subject><subject>Cellular biology</subject><subject>Cellular control mechanisms</subject><subject>CHO Cells</subject><subject>Cholesterol</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol Esters - metabolism</subject><subject>Cholesterols</subject><subject>COS cells</subject><subject>Cricetinae</subject><subject>Death</subject><subject>Female</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>HDL lipoproteins</topic><topic>Hepatocytes</topic><topic>High density lipoproteins</topic><topic>Lipids</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Membrane Proteins</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Ovaries</topic><topic>Ovary - metabolism</topic><topic>Proteins</topic><topic>Receptors</topic><topic>Receptors, Immunologic</topic><topic>Receptors, LDL - metabolism</topic><topic>Receptors, Lipoprotein - metabolism</topic><topic>Receptors, Scavenger</topic><topic>RNA-Binding Proteins</topic><topic>Scavenger Receptors, Class B</topic><topic>Thiazines - metabolism</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Acton, Susan</creatorcontrib><creatorcontrib>Rigotti, Attilio</creatorcontrib><creatorcontrib>Landschulz, 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LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8560269</pmid><doi>10.1126/science.271.5248.518</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-01, Vol.271 (5248), p.518-520 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77980439 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Adrenal Glands - metabolism Animals Biological and medical sciences Carrier Proteins CD36 Antigens - genetics CD36 Antigens - metabolism Cell lines Cell receptors Cell regulation Cell structures and functions Cellular biology Cellular control mechanisms CHO Cells Cholesterol Cholesterol - metabolism Cholesterol Esters - metabolism Cholesterols COS cells Cricetinae Death Female Fluorescent Dyes - metabolism Fundamental and applied biological sciences. Psychology HDL lipoproteins Hepatocytes High density lipoproteins Lipids Lipoproteins, HDL - metabolism Liver Liver - metabolism Membrane Proteins Mice Miscellaneous Molecular and cellular biology Molecular Sequence Data Ovaries Ovary - metabolism Proteins Receptors Receptors, Immunologic Receptors, LDL - metabolism Receptors, Lipoprotein - metabolism Receptors, Scavenger RNA-Binding Proteins Scavenger Receptors, Class B Thiazines - metabolism Transfection |
| title | Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor |
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