Air, methylcellulose, sodium hyaluronate and the corneal endothelium. Endothelial protective agents
In a randomised trial the endothelial protective agent used during extracapsular cataract extraction and intraocular lens insertion was air in 19 eyes (group 1), methylcellulose in 25 eyes (group 2) and sodium hyaluronate in 22 (group 3). The cell population densities of each eye were estimated imme...
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| Veröffentlicht in: | Eye (London) 1987-01, Vol.1 (4), p.480-486 |
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| creator | Muir, M G Kerr Sherrard, E S Andrews, V Steele, A D McG |
| description | In a randomised trial the endothelial protective agent used during extracapsular cataract extraction and intraocular lens insertion was air in 19 eyes (group 1), methylcellulose in 25 eyes (group 2) and sodium hyaluronate in 22 (group 3). The cell population densities of each eye were estimated immediately before and three months after the operations to determine the degree of cell loss. Eyes showing mechanical (touch) damage on the second postoperative day were eliminated. The numbers of eyes in each group which showed a statistically significant cell loss were compared, and the mean cell losses in each group were tested for significant differences. It appears that air actually damages the endothelium while methylcellulose and Na-hyaluronate are not harmful, and afford a high, essentially equal degree of endothelial protection. |
| doi_str_mv | 10.1038/eye.1987.72 |
| format | Article |
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Endothelial protective agents</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Muir, M G Kerr ; Sherrard, E S ; Andrews, V ; Steele, A D McG</creator><creatorcontrib>Muir, M G Kerr ; Sherrard, E S ; Andrews, V ; Steele, A D McG</creatorcontrib><description>In a randomised trial the endothelial protective agent used during extracapsular cataract extraction and intraocular lens insertion was air in 19 eyes (group 1), methylcellulose in 25 eyes (group 2) and sodium hyaluronate in 22 (group 3). The cell population densities of each eye were estimated immediately before and three months after the operations to determine the degree of cell loss. Eyes showing mechanical (touch) damage on the second postoperative day were eliminated. The numbers of eyes in each group which showed a statistically significant cell loss were compared, and the mean cell losses in each group were tested for significant differences. It appears that air actually damages the endothelium while methylcellulose and Na-hyaluronate are not harmful, and afford a high, essentially equal degree of endothelial protection.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/eye.1987.72</identifier><identifier>PMID: 3327710</identifier><identifier>CODEN: EYEEEC</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Air ; Biological and medical sciences ; Cell Count ; Clinical Trials as Topic ; Endothelium, Corneal - cytology ; Humans ; Hyaluronic Acid ; Hypromellose Derivatives ; Intraocular Pressure ; Laboratory Medicine ; Lenses, Intraocular ; Medical sciences ; Medicine ; Medicine & Public Health ; Methylcellulose - analogs & derivatives ; Middle Aged ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Postoperative Complications - prevention & control ; Random Allocation ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Surgical Oncology</subject><ispartof>Eye (London), 1987-01, Vol.1 (4), p.480-486</ispartof><rights>The Ophthalmological Society of the United Kingdom 1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-ba5ec0773a325c772f82dfb93c676467871b67281c4e70f6cac81a2dd34ae1d13</citedby><cites>FETCH-LOGICAL-c411t-ba5ec0773a325c772f82dfb93c676467871b67281c4e70f6cac81a2dd34ae1d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/eye.1987.72$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/eye.1987.72$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,23929,23930,25139,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7388038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3327710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muir, M G Kerr</creatorcontrib><creatorcontrib>Sherrard, E S</creatorcontrib><creatorcontrib>Andrews, V</creatorcontrib><creatorcontrib>Steele, A D McG</creatorcontrib><title>Air, methylcellulose, sodium hyaluronate and the corneal endothelium. Endothelial protective agents</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>In a randomised trial the endothelial protective agent used during extracapsular cataract extraction and intraocular lens insertion was air in 19 eyes (group 1), methylcellulose in 25 eyes (group 2) and sodium hyaluronate in 22 (group 3). The cell population densities of each eye were estimated immediately before and three months after the operations to determine the degree of cell loss. Eyes showing mechanical (touch) damage on the second postoperative day were eliminated. The numbers of eyes in each group which showed a statistically significant cell loss were compared, and the mean cell losses in each group were tested for significant differences. It appears that air actually damages the endothelium while methylcellulose and Na-hyaluronate are not harmful, and afford a high, essentially equal degree of endothelial protection.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Air</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Clinical Trials as Topic</subject><subject>Endothelium, Corneal - cytology</subject><subject>Humans</subject><subject>Hyaluronic Acid</subject><subject>Hypromellose Derivatives</subject><subject>Intraocular Pressure</subject><subject>Laboratory Medicine</subject><subject>Lenses, Intraocular</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Random Allocation</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1v2zAQhokiQeKmnToX1VB0qeXyQ9LRo2EkaYAAWVKgG0FTp1gBRaakFMD_vmfY8ZaJOLwPXx4fxr4IvhBc6V-4w4VYaliA_MBmooKmrKu6OmMzvqx5KaX8e8k-5vzMOYXAL9iFUhJA8Blzqz7NiwHH7c479H7yMeO8yLHtp6HY7qyfUgx2xMKGthi3WLiYAlpfYGgjzZ64RXH9NlDwkuKIbuxf6c4ThjF_Yued9Rk_H88r9ufm-nH9u7x_uL1br-5LVwkxlhtbo-MAyipZOwDZadl2m6VyDTRVAxrEpgGphasQeNc467Swsm1VZVG0Ql2xH4de2uDfhHk0Q5_3n7IB45QNwFLzSjYE_jyALsWcE3bmJfWDTTsjuNkrNaTU7JUakER_PdZOmwHbE3t0SPn3Y26zs75LNrg-nzBQWlMlYfMDlikJT5jMc5xSICHvvPrtgJP8KeGpjpg9QsR_sUWZpA</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>Muir, M G Kerr</creator><creator>Sherrard, E S</creator><creator>Andrews, V</creator><creator>Steele, A D McG</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870101</creationdate><title>Air, methylcellulose, sodium hyaluronate and the corneal endothelium. Endothelial protective agents</title><author>Muir, M G Kerr ; Sherrard, E S ; Andrews, V ; Steele, A D McG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-ba5ec0773a325c772f82dfb93c676467871b67281c4e70f6cac81a2dd34ae1d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Air</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Clinical Trials as Topic</topic><topic>Endothelium, Corneal - cytology</topic><topic>Humans</topic><topic>Hyaluronic Acid</topic><topic>Hypromellose Derivatives</topic><topic>Intraocular Pressure</topic><topic>Laboratory Medicine</topic><topic>Lenses, Intraocular</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Random Allocation</topic><topic>Surgery</topic><topic>Surgery (general aspects). 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Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muir, M G Kerr</creatorcontrib><creatorcontrib>Sherrard, E S</creatorcontrib><creatorcontrib>Andrews, V</creatorcontrib><creatorcontrib>Steele, A D McG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muir, M G Kerr</au><au>Sherrard, E S</au><au>Andrews, V</au><au>Steele, A D McG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Air, methylcellulose, sodium hyaluronate and the corneal endothelium. Endothelial protective agents</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>1987-01-01</date><risdate>1987</risdate><volume>1</volume><issue>4</issue><spage>480</spage><epage>486</epage><pages>480-486</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><coden>EYEEEC</coden><abstract>In a randomised trial the endothelial protective agent used during extracapsular cataract extraction and intraocular lens insertion was air in 19 eyes (group 1), methylcellulose in 25 eyes (group 2) and sodium hyaluronate in 22 (group 3). The cell population densities of each eye were estimated immediately before and three months after the operations to determine the degree of cell loss. Eyes showing mechanical (touch) damage on the second postoperative day were eliminated. The numbers of eyes in each group which showed a statistically significant cell loss were compared, and the mean cell losses in each group were tested for significant differences. 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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Air Biological and medical sciences Cell Count Clinical Trials as Topic Endothelium, Corneal - cytology Humans Hyaluronic Acid Hypromellose Derivatives Intraocular Pressure Laboratory Medicine Lenses, Intraocular Medical sciences Medicine Medicine & Public Health Methylcellulose - analogs & derivatives Middle Aged Ophthalmology Pharmaceutical Sciences/Technology Postoperative Complications - prevention & control Random Allocation Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Surgical Oncology |
| title | Air, methylcellulose, sodium hyaluronate and the corneal endothelium. Endothelial protective agents |
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