Aberrant hypermethylation at the bcl-2 locus at 18q21 in human lung cancers

Accumulating evidence suggests that altered DNA methylation may play a role in the oncogenesis of human neoplasms, including lung cancer. The presence of aberrant hypermthylations at 3p, 9p, 11p, ad 17p, which are known to be hot spots for allele loss in lung cancers, is suggested to be a reflection...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-04, Vol.56 (8), p.1886-1891
Hauptverfasser:	NAGATAKE, M, OSADA, H, KONDO, M, UCHIDA, K, NISHIO, M, SHIMOKATA, K, TAKAHASHI, TOSHITADA, TAKAHASHI, TAKASHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Biological and medical sciences Blotting, Southern Carcinoma, Large Cell - genetics Carcinoma, Large Cell - pathology Carcinoma, Small Cell - genetics Carcinoma, Small Cell - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Line Chromosome Mapping Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 18 DNA, Neoplasm - chemistry DNA, Neoplasm - isolation & purification Exons Genes, Retinoblastoma Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences Methylation Pneumology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 Proto-Oncogenes Restriction Mapping Tumors of the respiratory system and mediastinum
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