No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity

OBJECTIVE: Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Some previous studies using biochemical methods have found higher levels of COMT activity in schizophrenic patients. Recently, the genetic polymorphism that underlies variation in COMT act...

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Veröffentlicht in:The American journal of psychiatry 1996-02, Vol.153 (2), p.268-270
Hauptverfasser: DANIELS, J. K, WILLIAMS, N. M, MCGUFFIN, P, OWEN, M. J, WILLIAMS, J, JONES, L. A, CARDNO, A. G, MURPHY, K. C, SPURLOCK, G, RILEY, B, SCAMBLER, P, ASHERSON, P
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Sprache:eng
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