Oral antiplatelet, antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa antagonist

Currently used antiplatelet drugs, including aspirin and ticlopidine, are effective against certain but not all of the many endogenous platelet activators. Because of their limited efficacy, a significant number of serious thromboembolic complications still occur, highlighting the need for a more ef...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1996-02, Vol.93 (3), p.537-543
Hauptverfasser:	MOUSA, S. A, DEGRADO, W. F, DUN-XU MU, KAPIL, R. P, LUCCHESI, B. R, REILLY, T. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Administration, Oral Anesthesia, General Animals Biological and medical sciences Bleeding Time Blood. Blood coagulation. Reticuloendothelial system Capsules Coronary Thrombosis - prevention & control Dogs Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - pharmacokinetics Fibrinolytic Agents - therapeutic use In Vitro Techniques Male Medical sciences Mesylates - administration & dosage Mesylates - pharmacokinetics Mesylates - therapeutic use Peptides, Cyclic - administration & dosage Peptides, Cyclic - pharmacokinetics Peptides, Cyclic - therapeutic use Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacokinetics Platelet Aggregation Inhibitors - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors
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