Ischemic stroke in the elderly : role of the common factor V mutation causing resistance to activated protein C

A common missense mutation in coagulation factor V (Arg 506 Gln) creates phenotypic resistance to the anticoagulant effects of activated protein C and predisposes carriers to venous thrombosis. To assess a correlation between this common hypercoagulable state and ischemic cerebrovascular disease, we...

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Veröffentlicht in:	Stroke (1970) 1996, Vol.27 (1), p.44-48
Hauptverfasser:	PRESS, R. D, XIAO-YUAN LIU, BEAMER, N, COULL, B. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arginine - genetics Biological and medical sciences Brain Ischemia - etiology Case-Control Studies Cerebrovascular Disorders - etiology Factor V - genetics Female Fibrinolytic Agents - metabolism Heterozygote Humans Infant, Newborn Male Medical sciences Middle Aged Neurology Phenotype Point Mutation - genetics Polymerase Chain Reaction Prevalence Protein C - genetics Protein C - metabolism Risk Factors Thrombophlebitis - complications Thrombophlebitis - genetics Vascular diseases and vascular malformations of the nervous system
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