Concomitant overexpression of the EGFR and erbB‐2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis

Gene amplification or structural alteration of different erbB genes exerts a transforming effect in a variety of human neoplasms. Overexpression of the EGF receptor is associated with tumor initiation and progression of renal cell carcinoma (RCC). However, the role of erbB‐2 in these processes remai...

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Veröffentlicht in:	International journal of cancer 1996-02, Vol.69 (1), p.17-22
Hauptverfasser:	Stumm, Gabriele, Eberwein, Stefanie, Rostock‐Wolf, Sandra, Stein, Henning, Pomer, Siegfried, Schlegel, Jürgen, Waldherr, Rüdiger
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Southern Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Differentiation - physiology Female Gene Amplification Gene Expression Genes, erbB-2 Humans Immunohistochemistry In Situ Hybridization Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Male Medical sciences Middle Aged Neoplasm Metastasis Nephrology. Urinary tract diseases Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Tumors of the urinary system
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