Mouse embryos with paternal duplication of an imprinted chromosome 7 region die at midgestation and lack placental spongiotrophoblast

Imprinted genomic regions have been defined by the production of mice with uniparental inheritance or duplication of homologous chromosome regions. With most of the genome investigated, paternal duplication of only distal chromosomes 7 and 12 results in the lack of offspring, and prenatal lethality...

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Veröffentlicht in:	Development (Cambridge) 1996-01, Vol.122 (1), p.265-270
Hauptverfasser:	McLaughlin, K J, Szabó, P, Haegel, H, Mann, J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens - genetics Base Sequence Chromosome Aberrations DNA Primers - genetics Embryonic and Fetal Development - genetics Female Fetal Death - genetics Genomic Imprinting Insulin-Like Growth Factor II - genetics Male Mice Molecular Sequence Data Muscle Proteins - genetics Placenta - abnormalities Pregnancy Ribonucleoproteins, Small Nuclear RNA - genetics RNA - metabolism RNA, Long Noncoding RNA, Untranslated snRNP Core Proteins Trophoblasts - pathology
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