Immunoglobulin V Genes in Reed–Sternberg Cells
To the Editor: Hummel et al. (Oct. 5 issue) 1 report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concer...
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| Veröffentlicht in: | The New England journal of medicine 1996-02, Vol.334 (6), p.404-406 |
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| container_title | The New England journal of medicine |
| container_volume | 334 |
| creator | Küppers, R Kanzler, H Hansmann, M L Rajewsky, K |
| description | To the Editor:
Hummel et al. (Oct. 5 issue)
1
report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concerned about the reported results of this study.
In an analysis of single Reed–Sternberg cells micromanipulated from frozen tissue sections for heavy-chain (
VH
) and kappa light-chain (
V
κ) gene rearrangements, we detected clonal V gene rearrangements in 11 of 12 cases investigated, 3 which have already been reported.
2
No rearrangements . . . |
| doi_str_mv | 10.1056/NEJM199602083340615 |
| format | Article |
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Hummel et al. (Oct. 5 issue)
1
report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concerned about the reported results of this study.
In an analysis of single Reed–Sternberg cells micromanipulated from frozen tissue sections for heavy-chain (
VH
) and kappa light-chain (
V
κ) gene rearrangements, we detected clonal V gene rearrangements in 11 of 12 cases investigated, 3 which have already been reported.
2
No rearrangements . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199602083340615</identifier><identifier>PMID: 8538724</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Gene Rearrangement, B-Lymphocyte ; Genes, Immunoglobulin ; Hodgkin Disease - immunology ; Hodgkin Disease - pathology ; Humans ; Immunoglobulin Variable Region - genetics ; Phenotype ; Polymerase Chain Reaction ; Reed-Sternberg Cells - immunology</subject><ispartof>The New England journal of medicine, 1996-02, Vol.334 (6), p.404-406</ispartof><rights>Copyright © 1996 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-b85d9df68282ab4b699f51942109101fda3b8be89cdb803f147d054d0d4fe503</citedby><cites>FETCH-LOGICAL-c404t-b85d9df68282ab4b699f51942109101fda3b8be89cdb803f147d054d0d4fe503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199602083340615$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199602083340615$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8538724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Küppers, R</creatorcontrib><creatorcontrib>Kanzler, H</creatorcontrib><creatorcontrib>Hansmann, M L</creatorcontrib><creatorcontrib>Rajewsky, K</creatorcontrib><title>Immunoglobulin V Genes in Reed–Sternberg Cells</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Hummel et al. (Oct. 5 issue)
1
report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concerned about the reported results of this study.
In an analysis of single Reed–Sternberg cells micromanipulated from frozen tissue sections for heavy-chain (
VH
) and kappa light-chain (
V
κ) gene rearrangements, we detected clonal V gene rearrangements in 11 of 12 cases investigated, 3 which have already been reported.
2
No rearrangements . . .</description><subject>Gene Rearrangement, B-Lymphocyte</subject><subject>Genes, Immunoglobulin</subject><subject>Hodgkin Disease - immunology</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Phenotype</subject><subject>Polymerase Chain Reaction</subject><subject>Reed-Sternberg Cells - immunology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUM1Kw0AQXkSptfoEIuTkRaKz2Z_sHqXUWqkKWryGbHa2tGSTmk0O3nwH39AnMdLiScS5zAzfDx8fIacULikIefUwubunWktIQDHGQVKxR4ZUMBbz_tsnQ4BExTzV7JAchbCGfijXAzJQgqk04UMCM--7ql6WtenKVRW9RFOsMET9-YRoP98_nltsKoPNMhpjWYZjcuDyMuDJbo_I4mayGN_G88fpbHw9jwsOvI2NElZbJ1WiktxwI7V2gmqeUNAUqLM5M8qg0oU1CpijPLUguAXLHQpgI3K-td009WuHoc38KhR9gLzCugtZmuqUS5D_IUoheNoT2ZZYNHUIDbps06x83rxlFLLvPrNf-uxVZzv7zni0P5pdgT1-scW9D1mFa_-n2xdjCnt7</recordid><startdate>19960208</startdate><enddate>19960208</enddate><creator>Küppers, R</creator><creator>Kanzler, H</creator><creator>Hansmann, M L</creator><creator>Rajewsky, K</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960208</creationdate><title>Immunoglobulin V Genes in Reed–Sternberg Cells</title><author>Küppers, R ; Kanzler, H ; Hansmann, M L ; Rajewsky, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-b85d9df68282ab4b699f51942109101fda3b8be89cdb803f147d054d0d4fe503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Gene Rearrangement, B-Lymphocyte</topic><topic>Genes, Immunoglobulin</topic><topic>Hodgkin Disease - immunology</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Immunoglobulin Variable Region - genetics</topic><topic>Phenotype</topic><topic>Polymerase Chain Reaction</topic><topic>Reed-Sternberg Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Küppers, R</creatorcontrib><creatorcontrib>Kanzler, H</creatorcontrib><creatorcontrib>Hansmann, M L</creatorcontrib><creatorcontrib>Rajewsky, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Küppers, R</au><au>Kanzler, H</au><au>Hansmann, M L</au><au>Rajewsky, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin V Genes in Reed–Sternberg Cells</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1996-02-08</date><risdate>1996</risdate><volume>334</volume><issue>6</issue><spage>404</spage><epage>406</epage><pages>404-406</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>To the Editor:
Hummel et al. (Oct. 5 issue)
1
report the polyclonality of Reed–Sternberg cells in 6 of 12 cases of Hodgkin's disease. In three other cases, there were mixed polyclonal and monoclonal populations of Reed–Sternberg cells, and in three cases the cells were monoclonal. We are concerned about the reported results of this study.
In an analysis of single Reed–Sternberg cells micromanipulated from frozen tissue sections for heavy-chain (
VH
) and kappa light-chain (
V
κ) gene rearrangements, we detected clonal V gene rearrangements in 11 of 12 cases investigated, 3 which have already been reported.
2
No rearrangements . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>8538724</pmid><doi>10.1056/NEJM199602083340615</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1996-02, Vol.334 (6), p.404-406 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77974606 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Gene Rearrangement, B-Lymphocyte Genes, Immunoglobulin Hodgkin Disease - immunology Hodgkin Disease - pathology Humans Immunoglobulin Variable Region - genetics Phenotype Polymerase Chain Reaction Reed-Sternberg Cells - immunology |
| title | Immunoglobulin V Genes in Reed–Sternberg Cells |
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