The effects of hormone replacement therapy on uterine fibroids in postmenopausal women
To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids. Randomized clinical study. The Menopause Center of a public hospital. Postmenopausal women with small asymptomatic uterine fibroids were selected. One group was treat...
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| Veröffentlicht in: | Fertility and sterility 1996-02, Vol.65 (2), p.354-357 |
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| container_title | Fertility and sterility |
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| creator | Bilge Şener, A. Seçkin, Neslihan C. Özmen, Şelale Gökmen, Oya Doğu, Niyazi Ekici, Eyüp |
| description | To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids.
Randomized clinical study.
The Menopause Center of a public hospital.
Postmenopausal women with small asymptomatic uterine fibroids were selected.
One group was treated with 50μg transdermal E2 plus 5mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625mg conjugated equine estrogen plus 2.5mg MPA continuously.
The size of the uterine fibroids was measured before and after the first year of HRT.
At the end of the first year on HRT, the size of the uterine fibroids was re-evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.
Hormone replacement therapy with 50μg transdermal E2 plus 5mg MPA increases the size of the uterine fibroids. |
| doi_str_mv | 10.1016/S0015-0282(16)58098-4 |
| format | Article |
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Randomized clinical study.
The Menopause Center of a public hospital.
Postmenopausal women with small asymptomatic uterine fibroids were selected.
One group was treated with 50μg transdermal E2 plus 5mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625mg conjugated equine estrogen plus 2.5mg MPA continuously.
The size of the uterine fibroids was measured before and after the first year of HRT.
At the end of the first year on HRT, the size of the uterine fibroids was re-evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.
Hormone replacement therapy with 50μg transdermal E2 plus 5mg MPA increases the size of the uterine fibroids.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)58098-4</identifier><identifier>PMID: 8566261</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antineoplastic Agents, Hormonal - therapeutic use ; Biological and medical sciences ; Estradiol - therapeutic use ; Estrogen Replacement Therapy ; Female ; Hormone replacement therapy ; Hormones. Endocrine system ; Humans ; Leiomyoma - drug therapy ; leiomyoma uteri ; Medical sciences ; Medroxyprogesterone Acetate - therapeutic use ; Pharmacology. Drug treatments ; Postmenopause ; uterine fibroids ; Uterine Neoplasms - drug therapy</subject><ispartof>Fertility and sterility, 1996-02, Vol.65 (2), p.354-357</ispartof><rights>1996 American Society for Reproductive Medicine</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-3698f6db6f13e7008ecf186eb65d93fe9e320bef9df742d55f879a322c9c179a3</citedby><cites>FETCH-LOGICAL-c389t-3698f6db6f13e7008ecf186eb65d93fe9e320bef9df742d55f879a322c9c179a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216580984$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2993138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8566261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bilge Şener, A.</creatorcontrib><creatorcontrib>Seçkin, Neslihan C.</creatorcontrib><creatorcontrib>Özmen, Şelale</creatorcontrib><creatorcontrib>Gökmen, Oya</creatorcontrib><creatorcontrib>Doğu, Niyazi</creatorcontrib><creatorcontrib>Ekici, Eyüp</creatorcontrib><title>The effects of hormone replacement therapy on uterine fibroids in postmenopausal women</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids.
Randomized clinical study.
The Menopause Center of a public hospital.
Postmenopausal women with small asymptomatic uterine fibroids were selected.
One group was treated with 50μg transdermal E2 plus 5mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625mg conjugated equine estrogen plus 2.5mg MPA continuously.
The size of the uterine fibroids was measured before and after the first year of HRT.
At the end of the first year on HRT, the size of the uterine fibroids was re-evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.
Hormone replacement therapy with 50μg transdermal E2 plus 5mg MPA increases the size of the uterine fibroids.</description><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Estradiol - therapeutic use</subject><subject>Estrogen Replacement Therapy</subject><subject>Female</subject><subject>Hormone replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Leiomyoma - drug therapy</subject><subject>leiomyoma uteri</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause</subject><subject>uterine fibroids</subject><subject>Uterine Neoplasms - drug therapy</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVocB2nP8GgQynpYVN9WFrpVEpIk0Aghya9Cq12hBV2V1tpt8X_PnJsfO1pNLzPzIgHoTUl15RQ-e0XIVRUhCl2ReVXoYhW1eYMLakQshJS8A9oeUI-ooucXwkhktZsgRZKSMkkXaLfz1vA4D24KePo8TamPg6AE4ydddDDMOFpC8mOOxwHPE-QQol9aFIMbcZhwGPMU-HiaOdsO_wvluYSnXvbZfh0rCv08vP2-ea-eny6e7j58Vg5rvRUcamVl20jPeVQE6LAeaokNFK0mnvQwBlpwOvW1xvWCuFVrS1nzGlH968V-nLYO6b4Z4Y8mT5kB11nB4hzNnWt641gtIDiALoUc07gzZhCb9POUGL2Ps27T7OXZUr37tNsytz6eGBuemhPU0eBJf98zG12tvPJDi7kE8a05pSrgn0_YFBk_A2QTHYBBgdtSEW9aWP4z0feACMzktE</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>Bilge Şener, A.</creator><creator>Seçkin, Neslihan C.</creator><creator>Özmen, Şelale</creator><creator>Gökmen, Oya</creator><creator>Doğu, Niyazi</creator><creator>Ekici, Eyüp</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>The effects of hormone replacement therapy on uterine fibroids in postmenopausal women</title><author>Bilge Şener, A. ; Seçkin, Neslihan C. ; Özmen, Şelale ; Gökmen, Oya ; Doğu, Niyazi ; Ekici, Eyüp</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-3698f6db6f13e7008ecf186eb65d93fe9e320bef9df742d55f879a322c9c179a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Estradiol - therapeutic use</topic><topic>Estrogen Replacement Therapy</topic><topic>Female</topic><topic>Hormone replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Leiomyoma - drug therapy</topic><topic>leiomyoma uteri</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause</topic><topic>uterine fibroids</topic><topic>Uterine Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bilge Şener, A.</creatorcontrib><creatorcontrib>Seçkin, Neslihan C.</creatorcontrib><creatorcontrib>Özmen, Şelale</creatorcontrib><creatorcontrib>Gökmen, Oya</creatorcontrib><creatorcontrib>Doğu, Niyazi</creatorcontrib><creatorcontrib>Ekici, Eyüp</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bilge Şener, A.</au><au>Seçkin, Neslihan C.</au><au>Özmen, Şelale</au><au>Gökmen, Oya</au><au>Doğu, Niyazi</au><au>Ekici, Eyüp</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of hormone replacement therapy on uterine fibroids in postmenopausal women</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>65</volume><issue>2</issue><spage>354</spage><epage>357</epage><pages>354-357</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids.
Randomized clinical study.
The Menopause Center of a public hospital.
Postmenopausal women with small asymptomatic uterine fibroids were selected.
One group was treated with 50μg transdermal E2 plus 5mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625mg conjugated equine estrogen plus 2.5mg MPA continuously.
The size of the uterine fibroids was measured before and after the first year of HRT.
At the end of the first year on HRT, the size of the uterine fibroids was re-evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.
Hormone replacement therapy with 50μg transdermal E2 plus 5mg MPA increases the size of the uterine fibroids.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8566261</pmid><doi>10.1016/S0015-0282(16)58098-4</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Fertility and sterility, 1996-02, Vol.65 (2), p.354-357 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77974521 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents, Hormonal - therapeutic use Biological and medical sciences Estradiol - therapeutic use Estrogen Replacement Therapy Female Hormone replacement therapy Hormones. Endocrine system Humans Leiomyoma - drug therapy leiomyoma uteri Medical sciences Medroxyprogesterone Acetate - therapeutic use Pharmacology. Drug treatments Postmenopause uterine fibroids Uterine Neoplasms - drug therapy |
| title | The effects of hormone replacement therapy on uterine fibroids in postmenopausal women |
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